The cover image is based on the Original Article Epilepsy-related brain network alterations in patients with temporal lobe glioma in the right hemisphere by Tao Jiang et al., https://doi.org/10.1111/cns.13595.

Improving the QOL in patients with PD is an important concern, which can provide reference for decisions of policymakers and clinicians. PD patients had significantly poorer QOL, with moderate to large effect sizes in most domains. Moreover, different QOL measures had moderating effects on the results.

The quality of life of children with TSC is significantly lower than that of HCs. TSC2 mutation, epilepsy, early onset, long disease course and high reported seizure frequency (more than once a month), intellectual disability, and tuberous sclerosis–associated neuropsychiatric disorders are risk factors for poor quality of life.

The functional brain networks of the patients with Parkinson's disease (PD) with depression exhibite small-world architecture. PD depression is associated with disruptions in the topological organization of functional brain networks, mainly involved the temporal-occipital visual cortex and the posterior cingulate gyrus.

Sulcal pits analysis revealed decreased pits number in superficial secondary sulci and abnormal pit depth in multiple brain regions in boys with ADHD, providing new insights into this disease.

Intranasal administration of insulin causes direct delivery of insulin from nose to the various areas of the brain including substantia nigra and striatum. We showed that insulin can improve mitochondrial function indices and modulate mitochondrial biogenesis and fission as well as astrocytes and microglia activity which overall leads to improved motor performance in a rat model of Parkinson's disease.

Dynamic amplitude of low-frequency fluctuations and regional homogeneity changes existed in drug-resistant epilepsy patients with vagal nerve stimulators (VNS) under different current intensity and may provide possible therapeutic mechanisms of VNS.

• Adjunctive perampanel was associated with greater median percent reductions in seizure frequency per 28 days vs placebo in Chinese patients with focal or generalized seizure types during double-blind, randomized, phase III studies.
• During OLEx studies, adjunctive perampanel showed efficacy for up to 4 years for FS and FBTCS, and up to 2 years for GTCS.
• Perampanel was generally well tolerated during short- and long-term treatment.

ANT-DBS exerts neuroprotective effects on the caudate and putamen, enhances D1 and D2 receptor expression, and downregulates GPi overactivation, which enhanced the antiepileptic effect of the basal ganglia.

Sustained high-frequency stimulations (HFS) of 100 Hz pulses can suppress the population spikes (PS) in the epileptic afterdischarges induced by a short HFS in the rat hippocampal region. The possible mechanisms are a desynchronization of neuronal firing and a recovery of inhibitions in the local neuronal circuits. The findings provide new clues for developing brain stimulation therapy.

Right temporal glioma will make the nodal efficiency of the left part of the language network decline and increased degree centrality, nodal local efficiency, and nodal clustering coefficient of left part of the language network.