Diversity of hnRNP A1, hnRNP A2B1, and hnRNP K immunostaining across hippocampal subregions in Alzheimer's disease.

Progranulin knockout mice display a profound reduction in survival, as well as increased inflammation and cognitive impairment. Treatment of these mice with nicorandil—a K⁺ATP channel agonist, decreased mortality and improves cognitive impairment.

In progressive MS, mixed active plaques and perivascular inflammation in the sub/juxtacortical white matter correlate with similar (albeit fainter) pathologies in the cortical parenchyma

Aerobic exercise improves transfer of healthy mitochondria from astrocytes to neurons in the 5 × FAD mice.

In an archival epilepsy post-mortem collection from last century, chronic traumatic encephalopathy identified in 15.7% was associated with traumatic brain injury. Alzheimer's disease neuropathology change was increased in late-onset epilepsy but in 8% of cases with severe epilepsy there was no tau pathology found.

This study analyzes four public transcriptome datasets from AD patients and age-matched controls, revealing that the transcriptomic profile in female controls closely resembles that of AD patients. We identified a co-expressed gene module associated with AD, sex, and aging, enriched with immune-related functions. Notably, upregulated genes in female microglia, which substantially overlap with the co-expressed gene module, may serve as potential biomarkers to distinguish AD from normal individuals. This work highlights the importance of sex factor in AD research and treatment strategies.

A necrotizing myopathy without a perifascicular pattern is the most common pathological manifestation of anti-Ha ASS.