• Issue

    Basic & Clinical Pharmacology & Toxicology: Volume 130, Issue 4

    423-556
    April 2022
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ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 423-424
  • First Published: 11 March 2022

MINI REVIEWS

Clinical Pharmacology

Open Access

Sacubitril/valsartan, sodium-glucose cotransporter 2 inhibitors and vericiguat for congestive heart failure therapy

Tobias Norre,  Daniela Grimm,  Ulf Simonsen, 
  • Pages: 425-438
  • First Published: 06 February 2022

Basic Toxicology

Free Access

A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)

Jiangling Peng,  Mingjie Fan,  Chelsea An,  Feng Ni,  Wendong Huang,  Jiankang Luo, 
  • Pages: 439-456
  • First Published: 26 January 2022

ORIGINAL ARTICLES

Basic Pharmacology

Pro-inflammatory cytokines/chemokines, TNF-α, IL-6 and MCP-1, as biomarkers for the nephro- and pneumoprotective effect of silibinin after hepatic ischemia/reperfusion: Confirmation by immunohistochemistry and qRT-PCR

Georgios Kyriakopoulos,  Maria Lambropoulou,  Georgia Valsami,  Nikolaos Kostomitsopoulos,  Ourania Konstandi,  Konstantinos Anagnostopoulos,  Christos Tsalikidis,  Panagoula Oikonomou,  Konstantinos Simopoulos,  Alexandra K. Tsaroucha, 
  • Pages: 457-467
  • First Published: 06 January 2022
Open Access

Diclofenac in vitro microdialysis study comparing different experimental set-ups to improve quantitative recovery

Anselm Jorda,  Marianna Armogida,  Edith Lackner,  Sivasankari Saikumar,  Filip Sucharski,  Maria Weber,  Markus Zeitlinger, 
  • Pages: 468-480
  • First Published: 19 January 2022

Clinical Pharmacology

Open Access

Describing long-term opioid use utilizing Nordic prescription registers—A Norwegian example

Aleksi Hamina,  Vidar Hjellvik,  Marte Handal,  Ingvild Odsbu,  Thomas Clausen,  Svetlana Skurtveit, 
  • Pages: 481-491
  • First Published: 17 January 2022
Open Access

Plasma concentrations of methylphenidate enantiomers in adults with ADHD and substance use disorder, with focus on high doses and relationship to carboxylesterase activity

Michel Arvidsson,  Johan Franck,  Gerd Ackehed,  Madeleine Pettersson Bergstrand,  Lena Ekström,  Staffan Rosenborg,  Marja-Liisa Dahl, 
  • Pages: 492-500
  • First Published: 17 January 2022

Open Access

Use of chlorprothixene and the risk of diabetes and major adverse cardiovascular events: A nationwide cohort study

Mikkel Højlund,  Christina Blanner Wagner,  Rikke Wesselhoeft,  Kjeld Andersen,  Anders Fink-Jensen,  Jesper Hallas, 
  • Pages: 501-512
  • First Published: 04 February 2022
Open Access

The association of four genetic variants with myelosuppression in gemcitabine-treated Japanese is not evident in gemcitabine/carboplatin-treated Swedes

Niclas Björn,  Ingrid Jakobsen,  Chihiro Udagawa,  Eva Brandén,  Hirsh Koyi,  Rolf Lewensohn,  Luigi De Petris,  Hitoshi Zembutsu,  Henrik Gréen, 
  • Pages: 513-521
  • First Published: 07 February 2022

Effects of Zuojin Pill (Rhizoma Coptidis and Fructus Evodiae preparation) on the pharmacokinetics and side effects of venlafaxine in humans

Dongmin Yan,  Ming Wu,  Wenjuan Hu,  Yue Li,  Jingyi Jin,  Shaoqing Yan,  Wei Zhu,  Chaoyang Ye,  Jia Liu,  Guobin Liu,  Bo Tan, 
  • Pages: 522-530
  • First Published: 07 February 2022
Open Access

Olanzapine-associated dose-dependent alterations for weight and metabolic parameters in a prospective cohort

Georgios Schoretsanitis,  Céline Dubath,  Claire Grosu,  Marianna Piras,  Nermine Laaboub,  Setareh Ranjbar,  Nicolas Ansermot,  Séverine Crettol,  Frederik Vandenberghe,  Franziska Gamma,  Armin von Gunten,  Kerstin Jessica Plessen,  Erich Seifritz,  Philippe Conus,  Chin B. Eap, 
  • Pages: 531-541
  • First Published: 11 February 2022

Basic Toxicology

Open Access

SmartPAN: In vitro and in vivo proof-of-safety assessments for an intra-operative predictive indicator of postoperative pancreatic fistula

Thomas M. Pausch,  Marc Bartel,  Jiaqu Cui,  Ophelia Aubert,  Clara Mitzscherling,  Xinchun Liu,  Bodil Gesslein,  Peter Schuisky,  Felix K. F. Kommoss,  Thomas Bruckner,  Mohammad Golriz,  Arianeb Mehrabi,  Thilo Hackert, 
  • Pages: 542-552
  • First Published: 17 January 2022

SHORT COMMUNICATION

Clinical Toxicology

Atenolol and mortality events in patients with chronic kidney disease: Analysis of data from the Japanese Adverse Drug Event Report database

Satoru Mitsuboshi,  Takahiro Niimura,  Fuka Aizawa,  Mitsuhiro Goda,  Yoshito Zamami,  Keisuke Ishizawa, 
  • Pages: 553-556
  • First Published: 16 February 2022