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    Annals of Neurology: Volume 92, Issue 5

    C1, i-vi, 711-908
    November 2022
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Free Access

Annals of Neurology: Volume 92, Number 5, November 2022

  • Page: C1
  • First Published: 22 October 2022

Issue Information

Free Access

Issue Information

  • Pages: i-vi
  • First Published: 22 October 2022

Invited Commentary

Globalizing Research toward Diverse Representation in Alzheimer's and Parkinson's Disease

Bashayer Al-Mubarak PhD,  Mohamed Ahmed Nour MD,  Artur Schumacher-Schuh MD, PhD,  Sara Bandres-Ciga Pharm.D, PhD, 
  • Pages: 711-714
  • First Published: 24 August 2022

Review

Open Access

Effect Modification between Genes and Environment and Parkinson's Disease Risk

Maria Teresa Periñán PhD,  Kajsa Brolin MSc,  Sara Bandres-Ciga PhD,  Cornelis Blauwendraat PhD,  Christine Klein MD, PhD,  Ziv Gan-Or MD, PhD,  Andrew Singleton PhD,  Pilar Gomez-Garre PhD,  Maria Swanberg PhD,  Pablo Mir MD, PhD,  Alastair Noyce MD, PhD, 
  • Pages: 715-724
  • First Published: 01 August 2022

Mini Review

Re-Emergence of Poliovirus in the United States: Considerations and Implications

Grace B. Russo MD,  Tarini Goyal MD,  Kenneth Tyler MD,  Kiran T. Thakur MD, 
  • Pages: 725-728
  • First Published: 19 September 2022

Research Articles

Open Access

Amyloid-Related Imaging Abnormalities in the DIAN-TU-001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease

Nelly Joseph-Mathurin PhD,  Jorge J. Llibre-Guerra MD,  Yan Li PhD,  Austin A. McCullough BS,  Carsten Hofmann PhD,  Jakub Wojtowicz MSc Pharm, MRPharmS,  Ethan Park MS,  Guoqiao Wang PhD,  Gregory M. Preboske MS,  Qing Wang PhD,  Brian A. Gordon PhD,  Charles D. Chen BA,  Shaney Flores BS,  Neelum T. Aggarwal MD,  Sarah B. Berman MD, PhD,  Thomas D. Bird MD,  Sandra E. Black MD,  Bret Borowski RTR,  William S. Brooks MBBS, MPH,  Jasmeer P. Chhatwal MD, PhD,  Roger Clarnette PhD,  Carlos Cruchaga PhD,  Anne M. Fagan PhD,  Martin Farlow MD,  Nick C. Fox MD, FRCP,  Serge Gauthier MD, FRCPC,  Jason Hassenstab PhD,  Diana A. Hobbs PhD,  Karen C. Holdridge MPH,  Lawrence S. Honig MD, PhD,  Russ C. Hornbeck MSc,  Ging-Yuek R. Hsiung MD,  Clifford R. Jack Jr MD,  Ivonne Z. Jimenez-Velazquez MD,  Mathias Jucker PhD,  Gregory Klein PhD,  Johannes Levin MD, PhD,  Michele Mancini MD,  Mario Masellis PhD,  Nicole S. McKay PhD,  Catherine J. Mummery PhD,  John M. Ringman MD,  Hiroyuki Shimada MD, PhD,  B. Joy Snider MD, PhD,  Kazushi Suzuki MD, PhD,  David Wallon MD, PhD,  Chengjie Xiong PhD,  Roy Yaari MD,  Eric McDade DO,  Richard J. Perrin MD, PhD,  Randall J. Bateman MD,  Stephen P. Salloway MD, MS,  Tammie L.S. Benzinger MD, PhD,  David B. Clifford MD,  For the Dominantly Inherited Alzheimer Network Trials Unit , 
  • Pages: 729-744
  • First Published: 24 September 2022

Tau Mediates Synergistic Influence of Vascular Risk and Aβ on Cognitive Decline

Wai-Ying Wendy Yau MD,  Zahra Shirzadi PhD,  Hyun-Sik Yang MD,  Akpevweoghene P. Ikoba MS,  Jennifer S. Rabin PhD,  Michael J. Properzi BEng,  Dylan R. Kirn MPH,  Aaron P. Schultz PhD,  Dorene M. Rentz PsyD,  Keith A. Johnson MD,  Reisa A. Sperling MD,  Jasmeer P. Chhatwal MD, PhD, 
  • Pages: 745-755
  • First Published: 26 July 2022

Association between Human Blood Metabolome and the Risk of Alzheimer's Disease

Lulu Sun MD,  Daoxia Guo MD, PhD,  Yiming Jia MD,  Mengyao Shi MD, PhD,  Pinni Yang MD,  Yu Wang MD,  Fanghua Liu MD,  Guo-Chong Chen MD, PhD,  Yonghong Zhang MD, PhD,  Zhengbao Zhu MD, PhD, 
  • Pages: 756-767
  • First Published: 28 July 2022
Open Access

Microglial Activation and Connectivity in Alzheimer Disease and Aging

Boris-Stephan Rauchmann MD, MHBA,  Matthias Brendel MD, MHBA,  Nicolai Franzmeier PhD,  Lena Trappmann,  Mirlind Zaganjori,  Ersin Ersoezlue,  Estrella Morenas-Rodriguez PhD,  Selim Guersel,  Lena Burow MSc,  Carolin Kurz MD,  Jan Haeckert MD,  Maia Tatò MD,  Julia Utecht MD,  Boris Papazov MSc,  Oliver Pogarell MD,  Daniel Janowitz MD,  Katharina Buerger MD,  Michael Ewers PhD,  Carla Palleis MD,  Endy Weidinger MD,  Gloria Biechele,  Sebastian Schuster,  Anika Finze,  Florian Eckenweber MD,  Rainer Rupprecht MD,  Axel Rominger MD,  Oliver Goldhardt MD,  Timo Grimmer MD,  Daniel Keeser PhD,  Sophia Stoecklein MD,  Olaf Dietrich PhD,  Peter Bartenstein MD,  Johannes Levin MD,  Günter Höglinger MD,  Robert Perneczky MD, MBA, 
  • Pages: 768-781
  • First Published: 01 August 2022
Open Access

Antibody Response to HML-2 May Be Protective in Amyotrophic Lateral Sclerosis

Marta Garcia-Montojo PhD,  Elena Rita Simula MS,  Saeed Fathi BS,  Cynthia McMahan BS,  Anubrata Ghosal PhD,  James D. Berry MD, MPH,  Merit Cudkowicz MD, MSc,  Abdel Elkahloun PhD,  Kory Johnson PhD,  Gina Norato MS,  Peter Jensen BS,  Tony James BS,  Leonardo A. Sechi PhD,  Avindra Nath MD, 
  • Pages: 782-792
  • First Published: 31 July 2022
Open Access

Dystrophinopathy Phenotypes and Modifying Factors in DMD Exon 45–55 Deletion

Javier Poyatos-García MS,  Pilar Martí PhD,  Alessandro Liquori PhD,  Nuria Muelas MD, PhD,  Inmaculada Pitarch MD, PhD,  Luis Martinez-Dolz MD, PhD,  Benjamin Rodríguez PhD,  Lidia Gonzalez-Quereda PhD,  Maria Damiá PhD,  Elena Aller PhD,  Marta Selva-Gimenez MS,  Roger Vilchez MS,  Jordi Diaz-Manera MD, PhD,  Jorge Alonso-Pérez MD,  José Eulalio Barcena MD,  Amaia Jauregui MD, PhD,  Josep Gámez MD, PhD,  Jesus Angel Aladrén MD,  Ariadna Fernández MD,  Marisol Montolio PhD,  Inmaculada Azorin PhD,  David Hervas PhD,  Ana Casasús MS,  Marisa Nieto BS,  Pia Gallano PhD,  Teresa Sevilla MD, PhD,  Juan Jesus Vilchez MD, PhD, 
  • Pages: 793-806
  • First Published: 27 July 2022

Elevated Plasma Phosphorylated Tau 181 in Amyotrophic Lateral Sclerosis

Katheryn A. Q. Cousins PhD,  Leslie M. Shaw PhD,  Sanjana Shellikeri PhD,  Laynie Dratch ScM, CGC,  Luis Rosario BA,  Lauren B. Elman MD,  Colin Quinn MD,  Defne A. Amado MD, PhD,  David A. Wolk MD,  Thomas F. Tropea DO,  Alice Chen-Plotkin MD,  David J. Irwin MD,  Murray Grossman MDCM, EdD,  Edward B. Lee MD, PhD,  John Q. Trojanowski MD, PhD,  Corey T. McMillan PhD, 
  • Pages: 807-818
  • First Published: 25 July 2022
Open Access

Brain Connectivity Predicts Chronic Pain in Acute Mild Traumatic Brain Injury

Noam Bosak MD,  Paulo Branco PhD,  Pora Kuperman PhD,  Chen Buxbaum MD,  Ruth Manor Cohen MA,  Shiri Fadel BSc,  Rabab Zubeidat MHA,  Rafi Hadad MD,  Amir Lawen BSc,  Noam Saadon-Grosman PhD,  Michele Sterling PhD,  Yelena Granovsky PhD,  Apkar Vania Apkarian PhD,  David Yarnitsky MD,  Itamar Kahn PhD, 
  • Pages: 819-833
  • First Published: 02 August 2022

Network Effects of Brain Lesions Causing Central Poststroke Pain

Na Young Kim MD, PhD,  Joseph J. Taylor MD, PhD,  Yong Wook Kim MD, PhD,  David Borsook MD, PhD,  Juho Joutsa MD, PhD,  Jing Li,  Charles Quesada PhD,  Roland Peyron MD, PhD,  Michael D. Fox MD, PhD, 
  • Pages: 834-845
  • First Published: 02 August 2022

Salivary CGRP and Erenumab Treatment Response: Towards Precision Medicine in Migraine

Alicia Alpuente MD,  Victor J Gallardo MSc,  Laila Asskour MLT,  Edoardo Caronna MD,  Marta Torres-Ferrus MD, PhD,  Patricia Pozo-Rosich MD, PhD, 
  • Pages: 846-859
  • First Published: 07 August 2022
Open Access

Adjunct Thrombolysis Enhances Brain Reperfusion following Successful Thrombectomy

Carlos Laredo PhD,  Alejandro Rodríguez MD,  Laura Oleaga MD,  María Hernández-Pérez MD,  Arturo Renú MD,  Josep Puig MD,  Luis San Román MD,  Anna M. Planas PhD,  Xabier Urra MD,  Ángel Chamorro MD, 
  • Pages: 860-870
  • First Published: 07 August 2022
Open Access

5-Year Associations among Cerebral Arterial Pulsatility, Perivascular Space Dilation, and White Matter Lesions

Tomas Vikner MSc,  Nina Karalija PhD,  Anders Eklund PhD,  Jan Malm MD, PhD,  Anders Lundquist PhD,  Nikodemus Gallewicz MD,  Magnus Dahlin MD,  Ulman Lindenberger PhD,  Katrine Riklund MD, PhD,  Lars Bäckman PhD,  Lars Nyberg PhD,  Anders Wåhlin PhD, 
  • Pages: 871-881
  • First Published: 07 August 2022

Parenchymal Hemorrhage Rate Is Associated with Time to Reperfusion and Outcome

Jean-Marc Olivot MD, PhD,  Stephanos Finitsis MD,  Bertrand Lapergue MD, PhD,  Gaultier Marnat MD, PhD,  Igor Sibon MD, PhD,  Sebastien Richard MD, PhD,  Alain Viguier MD,  Christophe Cognard MD, PhD,  Mikael Mazighi MD, PhD,  Benjamin Gory MD, PhD, on behalf of the ETIS Registry Investigators , 
  • Pages: 882-887
  • First Published: 17 August 2022

Brief Communications

Open Access

Increased Phospho-AKT in Blood Cells from LRRK2 G2019S Mutation Carriers

Alicia Garrido MD,  Leticia Pérez-Sisqués PhD,  Cristina Simonet MD,  Genís Campoy-Campos MSc,  Júlia Solana-Balaguer MSc,  Núria Martín-Flores PhD,  Manel Fernández MSc,  Marta Soto MSc,  Donina Obiang RN,  Ana Cámara RN,  Francesc Valldeoriola MD, PhD,  Esteban Muñoz MD, PhD,  Yaroslau Compta MD, PhD,  Esther Pérez-Navarro PhD,  Jordi Alberch PhD,  Eduardo Tolosa MD, PhD,  María-José Martí MD, PhD,  Mario Ezquerra PhD,  Cristina Malagelada PhD,  Rubén Fernández-Santiago PhD, 
  • Pages: 888-894
  • First Published: 04 August 2022

Heterozygous NOTCH1 Variants Cause CNS Immune Activation and Microangiopathy

Guy Helman MD, PhD,  Parand Zarekiani MSc,  Samantha A.M. Tromp MSc,  Ashley Andrews CPNP,  Lorenzo D. Botto MD,  Joshua L. Bonkowsky MD, PhD,  Anna Chassevent ScM, CGC,  Elisa Giorgio PhD,  Tommaso Pippucci PhD,  Shen Wei PhD,  Constance Smith-Hicks MD, PhD,  Giovanna Vaula MD,  Michèl A.A.P Willemsen MD, PhD,  Mareike Schimmel MD,  Kurt Vollert MD,  Fumitaka Shimizu MD, PhD,  Takashi Kanda MD, PhD,  Matthew Lynch MBBS,  Tony Roscioli FRACP, PhD,  Ryan J. Taft PhD,  Cas Simons PhD,  Marianna Bugiani MD, PhD,  Taco W. Kuijpers MD, PhD,  Marjo S. van der Knaap MD, PhD, 
  • Pages: 895-901
  • First Published: 10 August 2022

Neuro-Images

Free Access

A Carotid Web with Atherosclerotic Plaque

Hui Zhang MD,  Jian Deng MD,  Yi Guo MD, PhD,  Yitao He MD, PhD, 
  • Pages: 902-903
  • First Published: 14 September 2022

Letters/Replies

Advanced Imaging for Mild Stroke Patients: Selection for Acute Interventions

Amie W. Hsia MD,  Marie Luby PhD,  Lawrence L. Latour PhD, 
  • Page: 904
  • First Published: 23 August 2022

Response to Letter by Hsia et al, Titled “Advanced Imaging for Mild Stroke Patients–Selection for Acute Interventions”

Amrou Sarraj MD,  Deep Pujara MBBS, MPH, MS,  Bruce CV Campbell MBBS, PhD, 
  • Page: 905
  • First Published: 23 August 2022

Inappropriateness of the Glasgow Coma Scale for Consciousness Assessment in COVID-19 Patients

Ting Zhang MD,  Ningning Chen MD,  Tingsong Li MD, PhD, 
  • Page: 906
  • First Published: 12 August 2022

Precision Vs. Personalized DBS for GBA-Related Parkinson Disease

Wilson K. W. Fung MD,  Melanie Cohn PhD, CPsych,  Anthony E. Lang MD,  Alfonso Fasano MD, PhD, 
  • Pages: 906-908
  • First Published: 02 September 2022