• Issue

    Annals of Neurology: Volume 87, Issue 2

    i-vi, 159-326
    February 2020
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Free Access

Annals of Neurology: Volume 87, Number 2, February 2020

  • First Published: 17 January 2020

Issue Information

Free Access

Issue Information

  • Pages: i-vi
  • First Published: 17 January 2020

Editorial

Passages 2020

  • Pages: 159-169
  • First Published: 07 January 2020

In Memoriam

In Memory of Wallace William Tourtellotte, MD, PhD (1924–2019)

Robert Baumhefner MD,  Claude Wasterlain MD,  Shri Mishra MD,  Kolar Murthy MD, 
  • Pages: 170-171
  • First Published: 25 December 2019

Invited Editorial

Open Access

Needle in a Haystack: The Common Can Inform the Rare in Restless Legs Syndrome

Joanne Trinh PhD,  Christine Klein MD, 
  • Pages: 172-174
  • First Published: 11 January 2020

Review

Central Role of Subthreshold Currents in Myotonia

Sabrina Metzger,  Chris Dupont,  Andrew A. Voss PhD,  Mark M. Rich MD, PhD, 
  • Pages: 175-183
  • First Published: 14 November 2019

Research Articles

Open Access

Identification of Restless Legs Syndrome Genes by Mutational Load Analysis

Erik Tilch PhD,  Barbara Schormair PhD,  Chen Zhao PhD,  Aaro V. Salminen PhD,  Ana Antic Nikolic MD,  Evi Holzknecht MD,  Birgit Högl MD,  Werner Poewe MD,  Cornelius G. Bachmann MD,  Walter Paulus MD,  Claudia Trenkwalder MD,  Wolfgang H. Oertel MD,  Magdolna Hornyak MD,  Ingo Fietze MD,  Klaus Berger MD,  Peter Lichtner PhD,  Christian Gieger PhD,  Annette Peters PhD,  Bertram Müller-Myhsok MD,  Alexander Hoischen PhD,  Juliane Winkelmann MD,  Konrad Oexle MD, 
  • Pages: 184-193
  • First Published: 01 December 2019

Restoration of Somatosensory Function by Pairing Vagus Nerve Stimulation with Tactile Rehabilitation

Michael J. Darrow PhD,  Tabarak M. Mian BS,  Miranda Torres BS,  Zainab Haider BS,  Tanya Danaphongse BS,  Robert L. Rennaker Jr PhD,  Michael P. Kilgard PhD,  Seth A. Hays PhD, 
  • Pages: 194-205
  • First Published: 25 December 2019

Effect of High-Caloric Nutrition on Survival in Amyotrophic Lateral Sclerosis

Albert C. Ludolph MD,  Johannes Dorst MD,  Jens Dreyhaupt PhD,  Jochen H. Weishaupt MD,  Jan Kassubek MD,  Ulrike Weiland MD,  Thomas Meyer MD,  Susanne Petri MD,  Andreas Hermann MD, PhD,  Alexander Emmer MD,  Julian Grosskreutz MD,  Torsten Grehl MD,  Daniel Zeller MD,  Matthias Boentert MD,  Bertold Schrank MD,  Johannes Prudlo MD,  Andrea S. Winkler MD,  Stanislav Gorbulev PhD,  Francesco Roselli MD, PhD,  Joachim Schuster PhD,  Luc Dupuis PhD,  for the LIPCAL-ALS Study Group , 
  • Pages: 206-216
  • First Published: 17 December 2019

ASC-1 Is a Cell Cycle Regulator Associated with Severe and Mild Forms of Myopathy

Rocío N. Villar-Quiles MD,  Fabio Catervi MS,  Eva Cabet PhD,  Raul Juntas-Morales MD,  Casie A. Genetti MS,  Teresa Gidaro MD, PhD,  Asuman Koparir MD,  Adnan Yüksel MD,  Sandra Coppens MD,  Nicolas Deconinck MD, PhD,  Emma Pierce-Hoffman BSc,  Xavière Lornage PhD,  Julien Durigneux MD,  Jocelyn Laporte PhD,  John Rendu PharmD, PhD,  Norma B. Romero MD, PhD,  Alan H. Beggs PhD,  Laurent Servais MD, PhD,  Mireille Cossée MD,  Montse Olivé MD, PhD,  Johann Böhm PhD,  Isabelle Duband-Goulet PhD,  Ana Ferreiro MD, PhD, 
  • Pages: 217-232
  • First Published: 03 December 2019
Open Access

Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE-TPA): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Study

Jong S. Kim MD,  Kyung Bok Lee MD,  Jong-Ho Park MD,  Sang Min Sung MD,  Kyungmi Oh MD,  Eung-Gyu Kim MD,  Dae-il Chang MD,  Yang Ha Hwang MD,  Eun-Jae Lee MD,  Won-Ki Kim PhD,  Chung Ju PhD,  Byung Su Kim MS,  Jei-Man Ryu PhD,  on behalf of the SAFE-TPA Investigators , 
  • Pages: 233-245
  • First Published: 13 November 2019

Early Intrathecal T Helper 17.1 Cell Activity in Huntington Disease

Marina R. von Essen MSc, PhD,  Marie N. N. Hellem MD,  Tua Vinther-Jensen MD, PhD,  Cecilie Ammitzbøll MD, PhD,  Rikke H. Hansen MSc,  Lena E. Hjermind MD, PhD,  Troels T. Nielsen MD, PhD,  Jørgen E. Nielsen MD, PhD,  Finn Sellebjerg MD, PhD, 
  • Pages: 246-255
  • First Published: 14 November 2019

Comparison of the Response to Rituximab between Myelin Oligodendrocyte Glycoprotein and Aquaporin-4 Antibody Diseases

Pierre Durozard MD,  Audrey Rico MD, PhD,  Clémence Boutiere MD,  Adil Maarouf MD, PhD,  Romaric Lacroix MD, PhD,  Sylvie Cointe MD, PhD,  Shirley Fritz MD,  Corinne Brunet MD,  Jean Pelletier MD, PhD,  Romain Marignier MD, PhD,  Bertrand Audoin MD, PhD, 
  • Pages: 256-266
  • First Published: 14 November 2019

Evolution of anosognosia in alzheimer's disease and its relationship to amyloid

Bernard J. Hanseeuw MD, PhD,  Matthew R. Scott BA,  Sietske A. M. Sikkes PhD,  Michael Properzi BEng,  Jennifer R. Gatchel MD, PhD,  Eric Salmon MD, PhD,  Gad A. Marshall MD,  Patrizia Vannini MD,  Alzheimer's Disease Neuroimaging Initiative , 
  • Pages: 267-280
  • First Published: 21 November 2019

SCN1A Variants in vaccine-related febrile seizures: A prospective study

John A. Damiano BSc (Hons),  Lucy Deng MBBS,  Wenhui Li MD,  Rosemary Burgess PhD,  Amy L. Schneider BSc (Hons),  Nigel W. Crawford MBBS, PhD,  Jim Buttery MD,  Michael Gold MB,CHB,  Peter Richmond MBBS,  Kristine K. Macartney MD,  Michael S. Hildebrand PhD,  Ingrid E. Scheffer MBBS, PhD,  Nicholas Wood MBBS, PhD,  Samuel F. Berkovic MD, FRS, 
  • Pages: 281-288
  • First Published: 22 November 2019

How the Human Brain Sleeps: Direct Cortical Recordings of Normal Brain Activity

Nicolás von Ellenrieder PhD,  Jean Gotman PhD,  Rina Zelmann PhD,  Christine Rogers BSc,  Dang Khoa Nguyen MD, PhD,  Philippe Kahane MD, PhD,  François Dubeau MD,  Birgit Frauscher MD, 
  • Pages: 289-301
  • First Published: 27 November 2019

Amyotrophic Lateral Sclerosis with Pallidonigroluysian Degeneration: A Clinicopathological Study

Junko Ito MD,  Hiroshi Shimizu MD, PhD,  Kentaro Ohta MD, PhD,  Jiro Idezuka MD, PhD,  Hajime Tanaka MD,  Hiroshi Kondo MD, PhD,  Takashi Nakajima MD, PhD,  Hitoshi Takahashi MD, PhD,  Kohei Akazawa PhD,  Osamu Onodera MD, PhD,  Akiyoshi Kakita MD, PhD, 
  • Pages: 302-312
  • First Published: 26 November 2019
Open Access

Randomized Placebo-Controlled Trial of Intravenous Immunoglobulin in Autoimmune LGI1/CASPR2 Epilepsy

Divyanshu Dubey MD,  Jeffrey Britton MD,  Andrew McKeon MD,  Avi Gadoth MD,  Anastasia Zekeridou MD,  Sebastian A. Lopez Chiriboga MD,  Michelle Devine MD,  Jane H. Cerhan PhD,  Katie Dunlay BS,  Jessica Sagen MA,  Melanie Ramberger PhD,  Patrick Waters PhD,  Sarosh R. Irani MD,  Sean J. Pittock MD, 
  • Pages: 313-323
  • First Published: 28 November 2019

Letters/Replies

Pregnancy, N-Methyl-D-Aspartate Receptor Antibodies, and Neuropsychiatric Diseases

Josep Dalmau MD, PhD, 
  • Pages: 324-325
  • First Published: 28 November 2019

Reply to “Pregnancy, N-Methyl-D-Aspartate Receptor Antibodies, and Neuropsychiatric Diseases”

Betty Jurek PhD,  Mariya Chayka,  Jakob Kreye MD,  Michael Koelch MD,  Harald Prüss MD, 
  • Pages: 325-326
  • First Published: 28 November 2019