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    Annals of Neurology: Volume 80, Issue 4

    479-637
    October 2016
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Annals of Neurology: Volume 80, Number 4, October 2016

  • First Published: 28 September 2016

Issue Information

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Issue Information – Copyright

  • First Published: 28 September 2016
Free Access

Issue Information – Table of Contents

  • First Published: 28 September 2016
Free Access

Issue Information – Masthead

  • First Published: 28 September 2016

Review

Zika virus: An emergent neuropathological agent

Martyn K. White D.Phil.,  Hassen S. Wollebo Ph.D.,  J. David Beckham M.D.,  Kenneth L. Tyler M.D.,  Kamel Khalili Ph.D., 
  • Pages: 479-489
  • First Published: 27 July 2016

Research Articles

Neuroanatomic Correlates of Female Sexual Dysfunction in Multiple Sclerosis

Klemens Winder MD,  Ralf A. Linker MD,  Frank Seifert MD,  Martina Deutsch MD,  Tobias Engelhorn MD,  Arnd Dörfler MD,  De-Hyung Lee MD,  Katharina M. Hösl MD,  Max J. Hilz MD, 
  • Pages: 490-498
  • First Published: 27 July 2016
Open Access

Long-term evolution of multiple sclerosis disability in the treatment era

University of California, San Francisco MS-EPIC Team: ,  Bruce A. C. Cree MD, PhD, MAS,  Pierre-Antoine Gourraud PhD, MPH,  Jorge R. Oksenberg PhD,  Carolyn Bevan MD, MS,  Elizabeth Crabtree-Hartman MD,  Jeffrey M. Gelfand MD, MAS,  Douglas S. Goodin MD,  Jennifer Graves MD, PhD, MAS,  Ari J. Green MD,  Ellen Mowry MD, MAS,  Darin T. Okuda MD,  Daniel Pelletier MD,  H.-Christian von Büdingen MD,  Scott S. Zamvil MD, PhD,  Alisha Agrawal,  Stacy Caillier,  Caroline Ciocca,  Refujia Gomez,  Rachel Kanner,  Robin Lincoln,  Antoine Lizee MSc,  Pamela Qualley,  Adam Santaniello,  Leena Suleiman,  Monica Bucci MD,  Valentina Panara MD,  Nico Papinutto PhD,  William A. Stern,  Alyssa H. Zhu MSc,  Gary R. Cutter PhD,  Sergio Baranzini PhD,  Roland G. Henry PhD,  Stephen L. Hauser MD, 
  • Pages: 499-510
  • First Published: 27 July 2016

Infantile spasms in down syndrome: Rescue by knockdown of the GIRK2 channel

Krutika Joshi BSc,  Lily Shen BSc,  Avner Michaeli PhD,  Michael Salter MD, PhD,  Gabrielle Thibault-Messier BSc,  Sumaiya Hashmi BSc,  James H. Eubanks PhD,  Miguel A. Cortez MD,  O. Carter Snead III, MD, 
  • Pages: 511-521
  • First Published: 27 July 2016

Microdialysis to Optimize Cord Perfusion and Drug Delivery in Spinal Cord Injury

Isaac Phang MRCS,  Argyro Zoumprouli MD,  Marios C. Papadopoulos MD, FRCS(SN),  Samira Saadoun PhD, 
  • Pages: 522-531
  • First Published: 27 July 2016

Statin therapy prevents the onset of Parkinson disease in patients with diabetes

Kun-Der Lin MD, PhD,  Chun-Yuh Yang PhD,  Mei-Yueh Lee MD,  Shu-Chen Ho PhD,  Ching-Kuan Liu MD, PhD,  Shyi-Jang Shin MD, PhD, 
  • Pages: 532-540
  • First Published: 29 July 2016

Bedside quantitative electroencephalography improves assessment of consciousness in comatose subarachnoid hemorrhage patients

Jan Claassen MD, PhD,  Angela Velazquez MD,  Emma Meyers BS,  Jens Witsch MD,  M. Cristina Falo PhD,  Soojin Park MD,  Sachin Agarwal MD,  J. Michael Schmidt PhD,  Nicholas D. Schiff MD,  Jacobo D. Sitt MD, PhD,  Lionel Naccache MD, PhD,  E. Sander Connolly MD,  Hans-Peter Frey PhD, 
  • Pages: 541-553
  • First Published: 29 July 2016

Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids

Mari Tada MD, PhD,  Takuya Konno MD, PhD,  Masayoshi Tada MD, PhD,  Toshiyuki Tezuka MD, PhD,  Takeshi Miura MD,  Naomi Mezaki MD,  Ken-ichi Okazaki MD, PhD,  Musashi Arakawa MD, PhD,  Kyoko Itoh MD, PhD,  Toru Yamamoto MD, PhD,  Hideaki Yokoo MD, PhD,  Nobuaki Yoshikura MD,  Kenji Ishihara MD,  Masao Horie PhD,  Hirohide Takebayashi MD, PhD,  Yasuko Toyoshima MD, PhD,  Makoto Naito MD, PhD,  Osamu Onodera MD, PhD,  Masatoyo Nishizawa MD, PhD,  Hitoshi Takahashi MD, PhD,  Takeshi Ikeuchi MD, PhD,  Akiyoshi Kakita MD, PhD, 
  • Pages: 554-565
  • First Published: 04 August 2016

Mycoplasma pneumoniae triggering the Guillain-Barré syndrome: A case-control study

Patrick M. Meyer Sauteur MD,  Ruth Huizinga PhD,  Anne P. Tio-Gillen BSc,  Joyce Roodbol MD,  Theo Hoogenboezem BSc,  Enno Jacobs MD,  Monique van Rijn MD,  Annemiek A. van der Eijk MD, PhD,  Cornelis Vink PhD,  Marie-Claire Y. de Wit MD, PhD,  Annemarie M.C. van Rossum MD, PhD,  Bart C. Jacobs MD, PhD, 
  • Pages: 566-580
  • First Published: 04 August 2016

A Novel Imaging Marker for Small Vessel Disease Based on Skeletonization of White Matter Tracts and Diffusion Histograms

Ebru Baykara MSc,  Benno Gesierich PhD,  Ruth Adam PhD,  Anil Man Tuladhar MD,  J. Matthijs Biesbroek MD, PhD,  Huiberdina L. Koek MD, PhD,  Stefan Ropele PhD,  Eric Jouvent MD, PhD,  Alzheimer's Disease Neuroimaging Initiative ,  Hugues Chabriat MD, PhD,  Birgit Ertl-Wagner MD,  Michael Ewers PhD,  Reinhold Schmidt MD,  Frank-Erik de Leeuw MD, PhD,  Geert Jan Biessels MD, PhD,  Martin Dichgans MD,  Marco Duering MD, 
  • Pages: 581-592
  • First Published: 12 August 2016

Cerebral white matter lesions and post-thrombolytic remote parenchymal hemorrhage

Sami Curtze MD, PhD,  Jukka Putaala MD, PhD,  Gerli Sibolt MD,  Susanna Melkas MD, PhD,  Satu Mustanoja MD, PhD,  Elena Haapaniemi MD, PhD,  Tiina Sairanen MD, PhD,  Marjaana Tiainen MD, PhD,  Turgut Tatlisumak MD, PhD,  Daniel Strbian MD, PhD, 
  • Pages: 593-599
  • First Published: 17 August 2016

ATXN2-AS, a gene antisense to ATXN2, is associated with spinocerebellar ataxia type 2 and amyotrophic lateral sclerosis

Pan P. Li Ph.D.,  Xin Sun Ph.D.,  Guangbin Xia M.D., Ph.D.,  Nicolas Arbez Ph.D.,  Sharan Paul Ph.D.,  Shanshan Zhu Ph.D.,  H. Benjamin Peng Ph.D.,  Christopher A. Ross M.D., Ph.D.,  Arnulf H. Koeppen M.D.,  Russell L. Margolis M.D.,  Stefan M. Pulst M.D.,  Tetsuo Ashizawa M.D.,  Dobrila D. Rudnicki Ph.D., 
  • Pages: 600-615
  • First Published: 17 August 2016

Preclinical disease activity in multiple sclerosis: A prospective study of cognitive performance prior to first symptom

Marianna Cortese MD,  Trond Riise MSc, PhD,  Kjetil Bjørnevik MD,  Alok Bhan MD,  Elisabeth Farbu MD, PhD,  Nina Grytten PhD,  Ineke Hogenesch MD,  Rune Midgard MD, PhD,  Cecilia Smith Simonsen MBChB,  Wenche Telstad MD,  Alberto Ascherio MD, DrPH,  Kjell-Morten Myhr MD, PhD, 
  • Pages: 616-624
  • First Published: 23 August 2016

Brief Communications

Multifocal nerve lesions and LZTR1 germline mutations in segmental schwannomatosis

Said Farschtschi MD,  Victor-Felix Mautner MD,  Mirko Pham MD,  Rosa Nguyen MD,  Hildegard Kehrer-Sawatzki PhD,  Sonja Hutter PhD,  Reinhard E. Friedrich MD,  Alexander Schulz MD, PhD,  Helen Morrison PhD,  David T. W. Jones PhD,  Martin Bendszus MD,  Philipp Bäumer MD, 
  • Pages: 625-628
  • First Published: 29 July 2016

Long-term preclinical magnetic resonance imaging alterations in sporadic Creutzfeldt–Jakob disease

Gianluigi Zanusso MD,  Giulia Camporese MD,  Sergio Ferrari MD,  Luca Santelli MD,  Matilde Bongianni PhD,  Michele Fiorini PhD,  Salvatore Monaco MD,  Renzo Manara MD,  Annachiara Cagnin MD, 
  • Pages: 629-632
  • First Published: 08 August 2016

KIF5A mutations cause an infantile onset phenotype including severe myoclonus with evidence of mitochondrial dysfunction

Jessica Duis MD, MS,  Shannon Dean MD, PhD,  Carolyn Applegate MGC, CGC,  Amy Harper MD,  Rui Xiao PhD,  Weimin He PhD,  James D. Dollar MD,  Lisa R. Sun MD,  Marta Biderman Waberski MD,  Thomas O. Crawford MD,  Ada Hamosh MD, MPH,  Carl E. Stafstrom MD, PhD, 
  • Pages: 633-637
  • First Published: 27 July 2016
Open Access

A recurrent mutation in KCNA2 as a novel cause of hereditary spastic paraplegia and ataxia

Katherine L. Helbig MS,  Ulrike B.S. Hedrich PhD,  Deepali N. Shinde PhD,  Ilona Krey,  Anne-Christin Teichmann Dipl-Ing,  Julia Hentschel PhD,  Julian Schubert PhD,  Adam C. Chamberlin PhD,  Robert Huether PhD,  Hsiao-Mei Lu PhD,  Wendy A. Alcaraz PhD,  Sha Tang PhD,  Chelsy Jungbluth MS,  Sarah L. Dugan MD,  Leena Vainionpää MD, PhD,  Kathrin N. Karle MD,  Matthis Synofzik MD,  Ludger Schöls MD,  Rebecca Schüle MD,  Anna-Elina Lehesjoki MD, PhD,  Ingo Helbig MD,  Holger Lerche MD,  Johannes R. Lemke MD, 
  • First Published: 20 August 2016