• Issue

    Annals of Neurology: Volume 69, Issue 1

    A9-A23, 1-220
    January 2011
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Message from the Editor

Thanks to Our Authors, Reviewers and Publisher

Stephen L. Hauser MD,  S. Claiborne Johnston MD, PhD,  Donna M. Ferriero MD,  S. Andrew Josephson MD,  Daniel H. Lowenstein MD,  Robert O. Messing MD,  Jorge R. Oksenberg PhD,  Cascade E. Wilhelm,  Adam F. Stewart, 
  • Page: A9
  • First Published: 28 January 2011

NerveCenter

NerveCenter: To immortalize a neurology pioneer

Kathlyn Stone, 
  • Pages: A19-A20
  • First Published: 28 January 2011

NerveCenter: Applying the lessons of HeLa cells to today's research

Kathlyn Stone, 
  • Pages: A21-A22
  • First Published: 28 January 2011

NerveCenter: The future of DNA databanks

  • Page: A22
  • First Published: 28 January 2011

Discoveries in Neuroscience

Discoveries in neuroscience

  • Page: A23
  • First Published: 28 January 2011

Editorial

The death panel for Charcot-Marie-Tooth panels

Anthony A. Amato MD,  Mary M. Reilly MD, 
  • Pages: 1-4
  • First Published: 28 October 2010

New pathway links γ-secretase to inflammation and memory while sparing notch

Sam Gandy,  Brandon Wustman, 
  • Pages: 5-7
  • First Published: 28 October 2010

Targeting amyloid precursor protein

Guido Hermey PhD, 
  • Pages: 8-10
  • First Published: 01 December 2010

Dissecting the familial risk of multiple sclerosis

John Hardy PhD,  Alan J. Thompson MD, 
  • Pages: 11-12
  • First Published: 14 December 2010

Medical Hypothesis

Pain and death: Neurodegenerative disease mechanisms in the nociceptor

David B. Reichling PhD,  Jon D. Levine MD, PhD, 
  • Pages: 13-21
  • First Published: 13 December 2010

Original Articles

Charcot-marie-tooth disease subtypes and genetic testing strategies

Anita S.D. Saporta MD,  Stephanie L. Sottile BA,  Lindsey J. Miller MS,  Shawna M.E. Feely MS,  Carly E. Siskind MS,  Michael E. Shy MD, 
  • Pages: 22-33
  • First Published: 28 January 2011

5-lipoxygenase as an endogenous modulator of amyloid beta formation in vivo

Jin Chu PhD,  Domenico Praticò MD, 
  • Pages: 34-46
  • First Published: 17 November 2010

SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk

Christiane Reitz MD, PhD,  Shinya Tokuhiro PhD,  Lorraine N. Clark PhD,  Christopher Conrad PhD,  Jean-Paul Vonsattel MD,  Lili-Naz Hazrati MD, PhD,  András Palotás MD, PhD,  Raphael Lantigua MD,  Martin Medrano MD,  Ivonne Z. Jiménez -Velázquez MD,  Badri Vardarajan MS,  Irene Simkin MS,  Jonathan L. Haines PhD,  Margaret A. Pericak -Vance PhD,  Lindsay A. Farrer PhD,  Joseph H. Lee PhD, DrPH,  Ekaterina Rogaeva PhD,  Peter St. George- Hyslop MD, FRCP,  Richard Mayeux MD, MSc, 
  • Pages: 47-64
  • First Published: 28 October 2010

Aggregation of multiple sclerosis genetic risk variants in multiple and single case families

Pierre-Antoine Gourraud PhD,  Joseph P. McElroy PhD,  Stacy J. Caillier BSc,  Britt A. Johnson PhD,  Adam Santaniello BA,  Stephen L. Hauser MD,  Jorge R. Oksenberg PhD, 
  • Pages: 65-74
  • First Published: 05 November 2010

Rapid Communication

Phase III dose-comparison study of glatiramer acetate for multiple sclerosis

Giancarlo Comi MD,  Jeffrey A. Cohen MD,  Douglas L. Arnold MD,  Daniel Wynn MD,  Massimo Filippi MD,  for the FORTE Study Group , 
  • Pages: 75-82
  • First Published: 29 October 2010

Original Articles

Axonal damage in relapsing multiple sclerosis is markedly reduced by natalizumab

Martin Gunnarsson MD, PhD,  Clas Malmeström MD, PhD,  Markus Axelsson MD,  Peter Sundström MD, PhD,  Charlotte Dahle MD, PhD,  Magnus Vrethem MD, PhD,  Tomas Olsson MD, PhD,  Fredrik Piehl MD, PhD,  Niklas Norgren PhD,  Lars Rosengren MD, PhD,  Anders Svenningsson MD, PhD,  Jan Lycke MD, PhD, 
  • Pages: 83-89
  • First Published: 28 October 2010

No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset

Claudio Baracchini MD,  Paola Perini MD,  Massimiliano Calabrese MD,  Francesco Causin MD,  Francesca Rinaldi MD,  Paolo Gallo MD, PhD, 
  • Pages: 90-99
  • First Published: 28 January 2011

Research Articles

Mitochondrial dysfunction in distal axons contributes to human immunodeficiency virus sensory neuropathy

Helmar C. Lehmann,  Weiran Chen,  Jasenka Borzan,  Joseph L. Mankowski,  Ahmet Höke, 
  • Pages: 100-110
  • First Published: 08 November 2010

Original Articles

The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: A randomized crossover clinical trial

Jean-Christophe Corvol MD, PhD,  Cécilia Bonnet MD,  Fanny Charbonnier-Beaupel PharmD,  Anne-Marie Bonnet MD,  Marie-Hélène Fiévet PharmD,  Agnès Bellanger PharmD,  Emmanuel Roze MD, PhD,  Gayané Meliksetyan MD,  Mouna Ben Djebara MD,  Andreas Hartmann MD,  Lucette Lacomblez MD,  Cédric Vrignaud BSc,  Noël Zahr PhD,  Yves Agid MD, PhD,  Jean Costentin MD,  Jean-Sébastien Hulot MD, PhD,  Marie Vidailhet MD, 
  • Pages: 111-118
  • First Published: 06 December 2010

Fingolimod provides long-term protection in rodent models of cerebral ischemia

Ying Wei MD,  Muge Yemisci MD, PhD,  Hyung-Hwan Kim PhD,  Lai Ming Yung PhD,  Hwa Kyoung Shin PhD,  Seo-Kyoung Hwang MS,  Shuzhen Guo PhD,  Tao Qin,  Nafiseh Alsharif,  Volker Brinkmann PhD,  James K Liao MD,  Eng H Lo PhD,  Christian Waeber PhD, 
  • Pages: 119-129
  • First Published: 12 November 2010

Arterial ischemic stroke risk factors: The international pediatric stroke study†

Mark T. Mackay MBBS,  Max Wiznitzer MD,  Susan L. Benedict MD,  Katherine J. Lee MSc, PhD,  Gabrielle A. deVeber MSc, MD,  Vijeya Ganesan MD,  on behalf of the International Pediatric Stroke Study Group , 
  • Pages: 130-140
  • First Published: 28 January 2011

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

Renée Douville PhD,  Jiankai Liu PhD,  Jeffrey Rothstein MD, PhD,  Avindra Nath MD, 
  • Pages: 141-151
  • First Published: 08 November 2010

Nuclear transport impairment of amyotrophic lateral sclerosis-linked mutations in FUS/TLS

Daisuke Ito MD, PhD,  Morinobu Seki MD,  Yoshiko Tsunoda,  Hidemi Uchiyama,  Norihiro Suzuki MD, PhD, 
  • Pages: 152-162
  • First Published: 08 December 2010

Timing of hormone therapy and dementia: The critical window theory revisited

Rachel A. Whitmer PhD,  Charles P. Quesenberry Jr, PhD,  Jufen Zhou MS,  Kristine Yaffe MD, 
  • Pages: 163-169
  • First Published: 12 November 2010

γ-Secretase component presenilin is important for microglia β-amyloid clearance

Dorit Farfara MSc,  Dorit Trudler BSc,  Niva Segev-Amzaleg MSc,  Ronit Galron BSc,  Reuven Stein PhD,  Dan Frenkel PhD, 
  • Pages: 170-180
  • First Published: 22 November 2010

Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease†

Victor L. Villemagne MD,  Kerryn E. Pike DPsych,  Gaël Chételat PhD,  Kathryn A. Ellis PhD,  Rachel S. Mulligan PhD,  Pierrick Bourgeat PhD,  Uwe Ackermann PhD,  Gareth Jones BSc,  Cassandra Szoeke MD,  Olivier Salvado PhD,  Ralph Martins PhD,  Graeme O'Keefe PhD,  Chester A. Mathis PhD,  William E. Klunk MD, PhD,  David Ames MD,  Colin L. Masters MD,  Christopher C. Rowe MD, 
  • Pages: 181-192
  • First Published: 28 January 2011

Brief Communications

Gait alterations in healthy carriers of the LRRK2 G2019S mutation†

Anat Mirelman PhD,  Tanya Gurevich MD,  Nir Giladi MD,  Anat Bar-Shira PhD,  Avi Orr-Urtreger MD, PhD,  Jeffrey M. Hausdorff PhD, 
  • Pages: 193-197
  • First Published: 28 January 2011

Motor nerve biopsy: Clinical usefulness and histopathological criteria†

Nilo Riva MD,  Sandro Iannaccone MD,  Massimo Corbo MD,  Chiara Casellato MD,  Barbara Sferrazza MD,  Alberto Lazzerini MD,  Marina Scarlato MD, PhD,  Federica Cerri MD,  Stefano C. Previtali MD, PhD,  Eduardo Nobile-Orazio MD, PhD,  Giancarlo Comi MD,  Angelo Quattrini MD, 
  • Pages: 197-201
  • First Published: 12 November 2010

Brief Communication

Ictal very low frequency oscillation in human epilepsy patients

Liankun Ren MD,  Kiyohito Terada MD,  Koichi Baba MD,  Naotaka Usui MD,  Shuichi Umeoka MD,  Keiko Usui MD,  Kazumi Matsuda MD,  Takayasu Tottori MD,  Fumihiro Nakamura MD,  Tadahiro Mihara MD,  Yushi Inoue MD, 
  • Pages: 201-206
  • First Published: 08 November 2010

Large genomic deletions: A novel cause of Ullrich congenital muscular dystrophy

A. Reghan Foley MD,  Ying Hu MS,  Yaqun Zou MD,  Michele Yang MD,  Līvija Medne MS, CGC,  Meganne Leach MSN, CRNP,  Laura K. Conlin PhD,  Nancy Spinner PhD,  Tamim H. Shaikh PhD,  Marni Falk MD,  Ann M. Neumeyer MD,  Laurie Bliss,  Brian S. Tseng MD, PhD,  Thomas L. Winder PhD, FACMG,  Carsten G. Bönnemann MD, 
  • Pages: 206-211
  • First Published: 28 October 2010

Letter to the Editor

Comment on validation of diagnostic criteria for variant Creutzfeldt-Jakob disease

Ana Lukic MRCP,  Simon Mead MRCP, PhD,  Peter Rudge FRCP,  John Collinge FRCP, PhD, FRS, 
  • Page: 212
  • First Published: 28 January 2011

Reply

Craig A. Heath MD,  Sarah A. Cooper MD,  Katy Murray MD,  Andrea Lowman MB ChB (Hons), MRCP,  Colm Henry MB MRCPI, MRCGP,  Margaret A. MacLeod MD, MRCP,  Gillian E. Stewart MB ChB,  Martin Zeidler FRCP,  Jan M. MacKenzie,  James W. Ironside FRCPath,  David M. Summers MD,  Richard S. G. Knight FRCP,  Robert G. Will FRCP, 
  • Pages: 212-213
  • First Published: 28 October 2010

Is pathological gambling in Parkinson's disease reduced by amantadine?

Jee-Young Lee MD,  Han- Joon Kim MD,  Beom S. Jeon MD, PhD, 
  • Pages: 213-214
  • First Published: 28 October 2010

Reply

Marco Onofrj MD,  Laura Bonanni MD, PhD,  Angelo Di Iorio MD, PhD,  Astrid Thomas MD, PhD, 
  • Pages: 214-215
  • First Published: 29 October 2010

Assessment of JC virus DNA in blood and urine from natalizumab-treated patients

Clemens Warnke MD,  Ortwin Adams MD,  Hans-Peter Hartung MD,  Bernd C. Kieseier MD, 
  • Pages: 215-216
  • First Published: 28 October 2010

Reply

Richard A. Rudick MD, 
  • Page: 216
  • First Published: 28 October 2010

Letter

José Luis Sandoval-Gutiérrez MD,  Magali Arcos MD,  Luis Alva MD,  Patricia Volkow MD,  Tabare Ferrari MD,  Francisco Quiñones MD,  Joel Vázquez-Pérez PhD,  Christopher E. Ormsby MSc,  Fabiola Hanssen MD,  Adrian Reséndiz MD,  Patricia Alcántara MD,  Rogelio Pérez Padilla MD,  Edgar Bautista MD, 
  • Page: 217
  • First Published: 28 October 2010

Reply

Paolo Mariotti MD,  Raffaele Iorio MD,  Giovanni Frisullo MD, PhD,  Domenico Plantone MD,  Raffaella Colantonio MD,  Tommaso Tartaglione MD,  Anna Paola Batocchi MD, PhD,  Piero Valentini MD, 
  • Pages: 217-218
  • First Published: 28 October 2010

Reply to a message from the editor

Ron Cohen MD,  Andrew R. Blight PhD, 
  • Pages: 218-220
  • First Published: 05 November 2010

Letter from the Editor

Reply

Stephen L. Hauser MD,  S. Claiborne Johnston MD, PhD, 
  • Page: 220
  • First Published: 28 January 2011