• Issue

    Hepatology: Volume 63, Issue 1

    1-349
    January 2016
Previous Issue|Next Issue
Export Citation(s)Download PDF(s)

Issue Information

Free Access

Table of contents

  • First Published: 21 December 2015
Free Access

Masthead

  • First Published: 21 December 2015

Hepatology Highlights

Free Access

Hepatology highlights

Jean-François Dufour, 
  • Pages: 1-3
  • First Published: 21 December 2015

Master's Perspective

Free Access

What have we learned about intrahepatic cholestasis of pregnancy?

Humberto Reyes, 
  • Pages: 4-8
  • First Published: 16 October 2015

Comments from the Editors

Free Access

Time to Abandon NASH?

Jean-François Dufour M.D., 
  • Pages: 9-10
  • First Published: 09 October 2015

Editorials

Free Access

Hepatitis B and D viral receptors

Jisu Li M.D., Ph.D.,  Jack Wands M.D., 
  • Pages: 11-13
  • First Published: 27 August 2015
Free Access

Flunarizine arrests hepatitis C virus membrane fusion

Daniil M. Prigozhin PH.D,  Yorgo Modis PH.D, 
  • Pages: 14-16
  • First Published: 21 September 2015
Free Access

Liver receptor homolog 1 and transmethylation fluxes in nonalcoholic steatohepatitis

José M. Mato Ph.D.,  Shelly C. Lu M.D., 
  • Pages: 17-19
  • First Published: 03 September 2015
Free Access

High prevalence of hepatic fibrosis in the setting of coexisting diabetes and hepatic steatosis: A case for selective screening in the general population?

Aijaz Ahmed M.D.,  Ryan B. Perumpail M.D.,  Stephen A. Harrison M.D., 
  • Pages: 20-22
  • First Published: 09 October 2015
Free Access

Circulating tumor cells and cholangiocarcinoma

Roberto Giovannoni,  Augusto Villanueva, 
  • Pages: 23-25
  • First Published: 11 September 2015
Free Access

Could gut microbiota protect against sclerosing cholangitis?

Hanns-Ulrich Marschall M.D.,  Fredrik Bäckhed Ph.D., 
  • Pages: 26-27
  • First Published: 27 August 2015
Free Access

No scientific basis to restrict 8 weeks of treatment with ledipasvir/sofosbuvir to patients with hepatitis C virus RNA <6,000,000 IU/mL

Thomas R. O'Brien M.D., M.P.H.,  Jordan J. Feld M.D., M.P.H.,  Shyam Kottilil M.D., PH.D.,  Ruth M. Pfeiffer PH.D., 
  • Pages: 28-30
  • First Published: 16 October 2015
Free Access

AASLD practice guidelines: The past, the present, and the future

Raphael B. Merriman M.D.,  Tram T. Tran M.D., 
  • Pages: 31-34
  • First Published: 13 November 2015

Viral Hepatitis

Free Access

A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses

Eloi R. Verrier,  Che C. Colpitts,  Charlotte Bach,  Laura Heydmann,  Amélie Weiss,  Mickaël Renaud,  Sarah C. Durand,  François Habersetzer,  David Durantel,  Georges Abou-Jaoudé,  Maria M. López Ledesma,  Daniel J. Felmlee,  Magali Soumillon,  Tom Croonenborghs,  Nathalie Pochet,  Michael Nassal,  Catherine Schuster,  Laurent Brino,  Camille Sureau,  Mirjam B. Zeisel,  Thomas F. Baumert, 
  • Pages: 35-48
  • First Published: 29 July 2015
Free Access

Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1

Paula M. Perin,  Sibylle Haid,  Richard J.P. Brown,  Juliane Doerrbecker,  Kai Schulze,  Carsten Zeilinger,  Markus von Schaewen,  Brigitte Heller,  Koen Vercauteren,  Eva Luxenburger,  Yasmine M. Baktash,  Florian W.R. Vondran,  Sietkse Speerstra,  Abdullah Awadh,  Furkat Mukhtarov,  Luis M. Schang,  Andreas Kirschning,  Rolf Müller,  Carlos A. Guzman,  Lars Kaderali,  Glenn Randall,  Philip Meuleman,  Alexander Ploss,  Thomas Pietschmann, 
  • Pages: 49-62
  • First Published: 06 August 2015
Free Access

Interferon lambda 4 genotypes and resistance-associated variants in patients infected with hepatitis C virus genotypes 1 and 3

Kai-Henrik Peiffer,  Lisa Sommer,  Simone Susser,  Johannes Vermehren,  Eva Herrmann,  Matthias Döring,  Julia Dietz,  Dany Perner,  Caterina Berkowski,  Stefan Zeuzem,  Christoph Sarrazin, 
  • Pages: 63-73
  • First Published: 25 September 2015
Free Access

Predictors of hepatitis B e antigen-negative hepatitis in chronic hepatitis B virus-infected patients from childhood to adulthood

Jia-Feng Wu,  Yu-Chun Chiu,  Kai-Chi Chang,  Huey-Ling Chen,  Yen-Hsuan Ni,  Hong-Yuan Hsu,  Mei-Hwei Chang, 
  • Pages: 74-82
  • First Published: 21 September 2015
Free Access

Indoleamine-2,3-dioxygenase as an effector and an indicator of protective immune responses in patients with acute hepatitis B

Sachiyo Yoshio,  Masaya Sugiyama,  Hirotaka Shoji,  Yohei Mano,  Eiji Mita,  Toru Okamoto,  Yoshiharu Matsuura,  Alato Okuno,  Osamu Takikawa,  Masashi Mizokami,  Tatsuya Kanto, 
  • Pages: 83-94
  • First Published: 12 October 2015

Steatohepatitis/Metabolic Liver Disease

Free Access

Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism

Martin Wagner,  Sungwoo Choi,  Katrin Panzitt,  Jennifer L. Mamrosh,  Jae Man Lee,  Alex Zaufel,  Rui Xiao,  Ruth Wooton-Kee,  Marcus Ståhlman,  Christopher B. Newgard,  Jan Borén,  David D. Moore, 
  • Pages: 95-106
  • First Published: 12 August 2015
Free Access

Peripheral insulin resistance predicts liver damage in nondiabetic subjects with nonalcoholic fatty liver disease

Chiara Rosso,  Lavinia Mezzabotta,  Melania Gaggini,  Federico Salomone,  Roberto Gambino,  Andrea Marengo,  Francesca Saba,  Ester Vanni,  Ramy Younes,  Chiara Saponaro,  Emma Buzzigoli,  Gian Paolo Caviglia,  Maria Lorena Abate,  Antonina Smedile,  Mario Rizzetto,  Maurizio Cassader,  Amalia Gastaldelli,  Elisabetta Bugianesi, 
  • Pages: 107-116
  • First Published: 16 October 2015

Free Access

Role of TM6SF2 rs58542926 in the pathogenesis of nonalcoholic pediatric fatty liver disease: A multiethnic study

Martina Goffredo,  Sonia Caprio,  Ariel E. Feldstein,  Ebe D'Adamo,  Melissa M. Shaw,  Bridget Pierpont,  Mary Savoye,  Hongyu Zhao,  Allen E. Bale,  Nicola Santoro, 
  • Pages: 117-125
  • First Published: 12 October 2015
Free Access

Differing impact of the deletion of hemochromatosis-associated molecules HFE and transferrin receptor-2 on the iron phenotype of mice lacking bone morphogenetic protein 6 or hemojuvelin

Chloé Latour,  Céline Besson-Fournier,  Delphine Meynard,  Laura Silvestri,  Ophélie Gourbeyre,  Patricia Aguilar-Martinez,  Paul J. Schmidt,  Mark D. Fleming,  Marie-Paule Roth,  Hélène Coppin, 
  • Pages: 126-137
  • First Published: 25 September 2015
Free Access

Presence of diabetes mellitus and steatosis is associated with liver stiffness in a general population: The Rotterdam study

Edith M. Koehler,  Elisabeth P.C. Plompen,  Jeoffrey N.L. Schouten,  Bettina E. Hansen,  Sarwa Darwish Murad,  Pavel Taimr,  Frank W.G. Leebeek,  Albert Hofman,  Bruno H. Stricker,  Laurent Castera,  Harry L.A. Janssen, 
  • Pages: 138-147
  • First Published: 14 July 2015

Hepatobiliary Malignancies

Free Access

Circulating tumor cells are associated with poor overall survival in patients with cholangiocarcinoma

Ju Dong Yang,  Michael B. Campion,  Minetta C. Liu,  Roongruedee Chaiteerakij,  Nasra H. Giama,  Hager Ahmed Mohammed,  Xiaodan Zhang,  Chunling Hu,  Victoria L. Campion,  Jin Jen,  Sudhakar K. Venkatesh,  Kevin C. Halling,  Benjamin R. Kipp,  Lewis R. Roberts, 
  • Pages: 148-158
  • First Published: 19 June 2015
Free Access

Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma

Yun-Yong Park,  Bo Hwa Sohn,  Randy L. Johnson,  Myoung-Hee Kang,  Sang Bae Kim,  Jae-Jun Shim,  Lingegowda S. Mangala,  Ji Hoon Kim,  Jeong Eun Yoo,  Cristian Rodriguez-Aguayo,  Sunila Pradeep,  Jun Eul Hwang,  Hee-Jin Jang,  Hyun-Sung Lee,  Rajesha Rupaimoole,  Gabriel Lopez-Berestein,  Woojin Jeong,  Inn Sun Park,  Young Nyun Park,  Anil K. Sood,  Gordon B. Mills,  Ju-Seog Lee, 
  • Pages: 159-172
  • First Published: 21 September 2015
Free Access

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

Xiaofang Sun,  Zhanhui Ou,  Ruochan Chen,  Xiaohua Niu,  De Chen,  Rui Kang,  Daolin Tang, 
  • Pages: 173-184
  • First Published: 24 September 2015

Autoimmune, Cholestatic and Biliary Disease

Free Access

Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis

James H. Tabibian,  Steven P. O'Hara,  Christy E. Trussoni,  Pamela S. Tietz,  Patrick L. Splinter,  Taofic Mounajjed,  Lee R. Hagey,  Nicholas F. LaRusso, 
  • Pages: 185-196
  • First Published: 04 June 2015

Liver Failure/Cirrhosis/Portal Hypertension

Free Access

Development of hyperdynamic circulation and response to β-blockers in compensated cirrhosis with portal hypertension

Càndid Villanueva,  Agustín Albillos,  Joan Genescà,  Juan G. Abraldes,  Jose L. Calleja,  Carles Aracil,  Rafael Bañares,  Rosa Morillas,  María Poca,  Beatriz Peñas,  Salvador Augustin,  Joan Carles Garcia-Pagan,  Oana Pavel,  Jaume Bosch, 
  • Pages: 197-206
  • First Published: 30 September 2015
Free Access

Vasopressin 1a receptor partial agonism increases sodium excretion and reduces portal hypertension and ascites in cirrhotic rats

Guillermo Fernández-Varo,  Denise Oró,  Edward Earl Cable,  Vedrana Reichenbach,  Silvia Carvajal,  Bernardino González de la Presa,  Kazimierz Wiśniewski,  Pere Ginés,  Geoffrey Harris,  Wladimiro Jiménez, 
  • Pages: 207-216
  • First Published: 24 September 2015

Liver Biology/Pathobiology

Free Access

Integrin αvβ6 critically regulates hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis

Zhen-Wei Peng,  Naoki Ikenaga,  Susan B. Liu,  Deanna Y. Sverdlov,  Kahini A. Vaid,  Richa Dixit,  Paul H. Weinreb,  Shelia Violette,  Dean Sheppard,  Detlef Schuppan,  Yury Popov, 
  • Pages: 217-232
  • First Published: 08 October 2015
Free Access

Bidirectional transendothelial migration of monocytes across hepatic sinusoidal endothelium shapes monocyte differentiation and regulates the balance between immunity and tolerance in liver

Henning W. Zimmermann,  Tony Bruns,  Chris J. Weston,  Stuart M. Curbishley,  Evaggelia Liaskou,  Ka-Kit Li,  Yazid J. Resheq,  Paul W. Badenhorst,  David H. Adams, 
  • Pages: 233-246
  • First Published: 16 October 2015
Free Access

Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase

Se-Hyuk Kim,  Yoon Jeon,  Hyun-Soo Kim,  Jin-Kwan Lee,  Han Jeong Lim,  Donglim Kang,  Hyeseong Cho,  Cheol-Keun Park,  Ho Lee,  Chang-Woo Lee, 
  • Pages: 247-259
  • First Published: 12 October 2015

Liver Capsule

Free Access

Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man

Jean Publicover,  Jillian M. Jespersen,  Audra J. Johnson,  Stephen L. Nishimura,  Amanda Goodsell,  Adil E. Wakil,  Philip Rosenthal,  Eric Pai,  Lia Avanesyan,  Stewart Cooper,  Jody L. Baron, 
  • Page: 260
  • First Published: 12 October 2015

Practice Guideline

Free Access

AASLD guidelines for treatment of chronic hepatitis B

Norah A. Terrault,  Natalie H. Bzowej,  Kyong-Mi Chang,  Jessica P. Hwang,  Maureen M. Jonas,  M. Hassan Murad, 
  • Pages: 261-283
  • First Published: 13 November 2015

Reviews

Free Access

Antiviral therapy for chronic hepatitis B viral infection in adults: A systematic review and meta-analysis

Anna S.F. Lok,  Brian J. McMahon,  Robert S. Brown Jr.,  John B. Wong,  Ahmed T. Ahmed,  Wigdan Farah,  Jehad Almasri,  Fares Alahdab,  Khalid Benkhadra,  Mohamed A. Mouchli,  Siddharth Singh,  Essa A. Mohamed,  Abd Moain Abu Dabrh,  Larry J. Prokop,  Zhen Wang,  Mohammad Hassan Murad,  Khaled Mohammed, 
  • Pages: 284-306
  • First Published: 13 November 2015
Free Access

Antiviral therapy in management of chronic hepatitis B viral infection in children: A systematic review and meta-analysis

Maureen M. Jonas,  Anna S.F. Lok,  Brian J. McMahon,  Robert S. Brown Jr.,  John B. Wong,  Ahmed T. Ahmed,  Wigdan Farah,  Mohamed A. Mouchli,  Siddharth Singh,  Larry J. Prokop,  Mohammad Hassan Murad,  Khaled Mohammed, 
  • Pages: 307-318
  • First Published: 13 November 2015
Free Access

Antiviral therapy in chronic hepatitis B viral infection during pregnancy: A systematic review and meta-analysis

Robert S. Brown Jr.,  Brian J. McMahon,  Anna S.F. Lok,  John B. Wong,  Ahmed T. Ahmed,  Mohamed A. Mouchli,  Zhen Wang,  Larry J. Prokop,  Mohammad Hassan Murad,  Khaled Mohammed, 
  • Pages: 319-333
  • First Published: 13 November 2015

Hepatology Elsewhere

Free Access

Breaking the species barrier for hepatitis delta virus

Benjamin Y. Winer M.S.,  Alexander Ploss PH.D., 
  • Pages: 334-336
  • First Published: 20 August 2015
Free Access

Cirrhosis and dysbiosis: New insights from next-generation sequencing

James Gorham M.D.,  Michael Gleeson PH.D., 
  • Pages: 336-338
  • First Published: 27 August 2015

Clinical Observations in Hepatology

Free Access

Fecal microbiota transplantation in the management of hepatic encephalopathy

Dina Kao,  Brandi Roach,  Heekuk Park,  Naomi Hotte,  Karen Madsen,  Vince Bain,  Puneeta Tandon, 
  • Pages: 339-340
  • First Published: 11 August 2015

Correspondence

Free Access

Telomerase reverse transcriptase promoter methylation is related to a risk of recurrence in hepatocellular carcinoma

Eunkyong Ko Ph.D.,  Eun Sun Jung M.D., Ph.D.,  Guhung Jung Ph.D., 
  • Page: 341
  • First Published: 04 April 2015
Free Access

Reply

Jean-Charles Nault M.D.,  Julien Calderaro M.D., Ph.D.,  Jessica Zucman-Rossi M.D., Ph.D., 
  • Page: 342
  • First Published: 04 April 2015
Free Access

Portal vein thrombosis and chronic liver disease progression: The closer you look the more you see

Edoardo G. Giannini M.D., PH.D., F.A.C.G.,  R. Todd Stravitz M.D.,  Stephen H. Caldwell M.D., 
  • Pages: 342-343
  • First Published: 30 April 2015
Free Access

Model for end-stage liver disease-based allocation system: On the right path, but not there yet

Ângelo Zambam de Mattos M.D. M.Sc., Ph.D.,  Angelo Alves de Mattos M.D. M.Sc., Ph.D., 
  • Page: 344
  • First Published: 22 March 2015
Free Access

Hepatocellular carcinoma: To resect or to transplant?

Ângelo Zambam de Mattos M.D., M.Sc., Ph.D.,  Angelo Alves de Mattos M.D., M.Sc., Ph.D., 
  • Pages: 344-345
  • First Published: 29 May 2015
Free Access

Reply

Kheng Choon Lim M.D.,  Pierce K.H. Chow M.B.B.S., PH.D., 
  • Page: 345
  • First Published: 29 May 2015
Free Access

Serum alkaline phosphatase in multidrug resistance 2 (Mdr2–/–) knockout mice is strain specific

Palak J. Trivedi B.SC. (HONS.), M.B.B.S., M.R.C.P. (U.K.),  Chris J. Weston B.SC., PH.D.,  Gwilym J. Webb M.A., M.R.C.P.,  Philip N. Newsome M.B. CH.B., M.R.C.P., PH.D.,  Gideon M. Hirschfield M.B. B.CHIR., PH.D., F.R.C.P.1,2,  David H. Adams M.D., F.R.C.P., F.MED.SCI., 
  • Page: 346
  • First Published: 30 April 2015
Free Access

Reply

Elisabeth Krones M.D.,  Wolfgang Erwa M.D.,  Michael Trauner M.D.,  Peter Fickert M.D., 
  • Pages: 346-347
  • First Published: 30 April 2015
Free Access

Contribution of nonignorable environmental factor to impairing liver disease mortality reduction target in China

Chao Dong M.D.,  Shifang Peng M.D., PH.D., 
  • Pages: 347-348
  • First Published: 07 May 2015
Free Access

Reply

Zheng Zhang M.D, PH.D.,  Bin Gao M.D, PH.D.,  Fu-Sheng Wang M.D., PH.D., 
  • Page: 348
  • First Published: 07 May 2015

Corrections

Free Access

Serum hepatitis B virus RNA levels as an early predictor of hepatitis B envelope antigen seroconversion during treatment with polymerase inhibitors

  • Page: 349
  • First Published: 21 December 2015

Free Access

Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor–induced epithelial-mesenchymal transition

  • Page: 349
  • First Published: 21 December 2015

Free Access

Portal hypertension and the outcome of surgery for hepatocellular carcinoma in compensated cirrhosis: A systematic review and meta-analysis

  • Page: 349
  • First Published: 21 December 2015

Issue Information

Free Access

Copyright permission request form

  • First Published: 21 December 2015
Free Access

Information for readers

  • First Published: 21 December 2015
Free Access

Instructions for authors

  • First Published: 21 December 2015
Free Access

Notices

  • First Published: 21 December 2015