• Issue

    Hepatology: Volume 62, Issue 2

    327-661
    August 2015
Previous Issue|Next Issue
Export Citation(s)Download PDF(s)

Hepatology Highlights

Free Access

Hepatology highlights

Jean-François Dufour, 
  • Pages: 327-329
  • First Published: 23 July 2015

Comments from the Editors

Free Access

Paradoxes in studies of liver regeneration: Relevance of the parable of the blind men and the elephant

Lola M. Reid, 
  • Pages: 330-333
  • First Published: 25 May 2015

Editorials

Free Access

Value anti–hepatitis C virus therapy by its clinical efficacy

Adriaan J. van der Meer M.D., Ph.D., 
  • Pages: 334-336
  • First Published: 18 April 2015
Free Access

Glyceronephosphate O-acyltransferase as a hemochromatosis modifier gene: Another iron in the fire?

Priya Handa Ph.D.,  Kris V. Kowdley M.D., 
  • Pages: 337-339
  • First Published: 29 March 2015
Free Access

Surgical resection for hepatocellular carcinoma: Moving from what can be done to what is worth doing

Renato Romagnoli M.D., F.E.B.S.,  Vincenzo Mazzaferro M.D.,  Jordi Bruix M.D., 
  • Pages: 340-342
  • First Published: 04 April 2015
Free Access

A new VETC in hepatocellular carcinoma metastasis

Kaisa L. Hanley B.Sc.,  Gen-Sheng Feng Ph.D., 
  • Pages: 343-345
  • First Published: 21 April 2015
Free Access

Inhibition of immune tolerance unmasks drug-induced allergic hepatitis

Jack Uetrecht,  Neil Kaplowitz, 
  • Pages: 346-348
  • First Published: 01 April 2015
Free Access

Treating genetic disease: Expanding the options

Richard J. Thompson M.D.,  Laura N. Bull Ph.D., 
  • Pages: 349-351
  • First Published: 29 March 2015
Free Access

Hepatorenal syndrome: The last pieces of the puzzle or not yet?

Isabel Graupera M.D,  Pere Ginès M.D., 
  • Pages: 352-354
  • First Published: 04 April 2015

Viral Hepatitis

Free Access

Toward a more complete understanding of the association between a hepatitis C sustained viral response and cause-specific outcomes

Hamish A. Innes,  Scott A. McDonald,  John F. Dillon,  Sam Allen,  Peter C. Hayes,  David Goldberg,  Peter R. Mills,  Stephen T. Barclay,  David Wilks,  Heather Valerio,  Ray Fox,  Diptendu Bhattacharyya,  Nicholas Kennedy,  Judith Morris,  Andrew Fraser,  Adrian J. Stanley,  Peter Bramley,  Sharon J. Hutchinson, 
  • Pages: 355-364
  • First Published: 26 February 2015
Free Access

Effect of addition of statins to antiviral therapy in hepatitis C virus–infected persons: Results from ERCHIVES

Adeel A. Butt,  Peng Yan,  Hector Bonilla,  Abdul-Badi Abou-Samra,  Obaid S. Shaikh,  Tracey G. Simon,  Raymond T. Chung,  Shari S. Rogal,  for the ERCHIVES (Electronically Retrieved Cohort of HCV Infected Veterans) Study Team , 
  • Pages: 365-374
  • First Published: 06 April 2015
Free Access

Efficacy of maternal tenofovir disoproxil fumarate in interrupting mother-to-infant transmission of hepatitis B virus

Huey-Ling Chen,  Chien-Nan Lee,  Chin-Hao Chang,  Yen-Hsuan Ni,  Ming-Kwang Shyu,  Shih-Ming Chen,  Jen-Jan Hu,  Hans Hsienhong Lin,  Lu-Lu Zhao,  Shu-Chi Mu,  Ming-Wei Lai,  Chyi-Long Lee,  Hsien-Ming Lin,  Ming-Song Tsai,  Jenn-Jeih Hsu,  Ding-Shinn Chen,  K. Arnold Chan,  Mei-Hwei Chang,  Taiwan Study Group for the Prevention of Mother-to-Infant Transmission of HBV (PreMIT Study) , 
  • Pages: 375-386
  • First Published: 07 April 2015
Free Access

Prevention of acute exacerbation of chronic hepatitis B infection in cancer patients receiving chemotherapy in a hepatitis B virus endemic area

Ping-I Hsu,  Kwok-Hung Lai,  Jin-Shiung Cheng,  Sung-Shuo Kao,  Yuan-Rung Li,  Wei-Chih Sun,  Wen-Chi Chen,  Kung-Hung Lin,  Chih-An Shin,  Po-Hung Chiang,  Yun-Da Li,  Wei-Ting Ou,  Hui-Chun Chen,  Hsien-Chung Yu, 
  • Pages: 387-396
  • First Published: 09 April 2015
Free Access

Novel perspectives for hepatitis A virus therapy revealed by comparative analysis of hepatitis C virus and hepatitis A virus RNA replication

Katharina Esser-Nobis,  Christian Harak,  Philipp Schult,  Yuri Kusov,  Volker Lohmann, 
  • Pages: 397-408
  • First Published: 11 April 2015
Free Access

Cardiac dysfunction associated with a nucleotide polymerase inhibitor for treatment of hepatitis C

Tariq Ahmad,  Philip Yin,  Jeffrey Saffitz,  Paul J. Pockros,  Jacob Lalezari,  Mitchell Shiffman,  Bradley Freilich,  Joann Zamparo,  Kyle Brown,  Dessislava Dimitrova,  Monica Kumar,  Doug Manion,  Margo Heath-Chiozzi,  Robert Wolf,  Eric Hughes,  Andrew J. Muir,  Adrian F. Hernandez, 
  • Pages: 409-416
  • First Published: 24 September 2014

Steatohepatitis/Metabolic Liver Disease

Free Access

Modeling correction of severe urea cycle defects in the growing murine liver using a hybrid recombinant adeno-associated virus/piggyBac transposase gene delivery system

Sharon C. Cunningham,  Susan M. Siew,  Claus V. Hallwirth,  Christine Bolitho,  Natsuki Sasaki,  Gagan Garg,  Iacovos P. Michael,  Nicola A. Hetherington,  Kevin Carpenter,  Gustavo de Alencastro,  Andras Nagy,  Ian E. Alexander, 
  • Pages: 417-428
  • First Published: 09 April 2015
Free Access

Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload

Christine E. McLaren,  Mary J. Emond,  V. Nathan Subramaniam,  Pradyumna D. Phatak,  James C. Barton,  Paul C. Adams,  Justin B. Goh,  Cameron J. McDonald,  Lawrie W. Powell,  Lyle C. Gurrin,  Katrina J. Allen,  Deborah A. Nickerson,  Tin Louie,  Grant A. Ramm,  Gregory J. Anderson,  Gordon D. McLaren, 
  • Pages: 429-439
  • First Published: 20 January 2015

Hepatobiliary Malignancies

Free Access

The role of hepatic resection in the treatment of hepatocellular cancer

Sasan Roayaie,  Ghalib Jibara,  Parissa Tabrizian,  Joong-Won Park,  Jijin Yang,  Lunan Yan,  Myron Schwartz,  Guohong Han,  Francesco Izzo,  Mishan Chen,  Jean-Frédéric Blanc,  Philip Johnson,  Masatoshi Kudo,  Lewis R. Roberts,  Morris Sherman, 
  • Pages: 440-451
  • First Published: 11 February 2015
Free Access

A novel vascular pattern promotes metastasis of hepatocellular carcinoma in an epithelial–mesenchymal transition–independent manner

Jian-Hong Fang,  Hui-Chao Zhou,  Chong Zhang,  Li-Ru Shang,  Lei Zhang,  Jing Xu,  Limin Zheng,  Yunfei Yuan,  Rong-Ping Guo,  Wei-Hua Jia,  Jing-Ping Yun,  Min-Shan Chen,  Yaojun Zhang,  Shi-Mei Zhuang, 
  • Pages: 452-465
  • First Published: 24 February 2015
Open Access

MicroRNA-494 is a master epigenetic regulator of multiple invasion-suppressor microRNAs by targeting ten eleven translocation 1 in invasive human hepatocellular carcinoma tumors

Kuang-Hsiang Chuang,  Christa L. Whitney-Miller,  Chin-Yi Chu,  Zhongren Zhou,  M. Katherine Dokus,  Shannon Schmit,  Christopher T. Barry, 
  • Pages: 466-480
  • First Published: 29 March 2015
Free Access

Hepatic stellate cell and monocyte interaction contributes to poor prognosis in hepatocellular carcinoma

Juling Ji,  Tobias Eggert,  Anuradha Budhu,  Marshonna Forgues,  Atsushi Takai,  Hien Dang,  Qinghai Ye,  Ju-Seog Lee,  Ji Hoon Kim,  Tim F. Greten,  Xin Wei Wang, 
  • Pages: 481-495
  • First Published: 01 April 2015
Free Access

Global DNA methylation and hydroxymethylation differ in hepatocellular carcinoma and cholangiocarcinoma and relate to survival rate

Silvia Udali,  Patrizia Guarini,  Sara Moruzzi,  Andrea Ruzzenente,  Stephanie A. Tammen,  Alfredo Guglielmi,  Simone Conci,  Patrizia Pattini,  Oliviero Olivieri,  Roberto Corrocher,  Sang-Woon Choi,  Simonetta Friso, 
  • Pages: 496-504
  • First Published: 01 April 2015
Free Access

The camKK2/camKIV relay is an essential regulator of hepatic cancer

Fumin Lin,  Kathrina L. Marcelo,  Kimal Rajapakshe,  Cristian Coarfa,  Adam Dean,  Nathaniel Wilganowski,  Holly Robinson,  Eva Sevick,  Karl-Dimiter Bissig,  Lauren C. Goldie,  Anthony R. Means,  Brian York, 
  • Pages: 505-520
  • First Published: 04 April 2015
Free Access

Cd11b+ myeloid cells support hepatic metastasis through down-regulation of angiopoietin-like 7 in cancer cells

Su Yin Lim,  Alex Gordon-Weeks,  Danny Allen,  Veerle Kersemans,  John Beech,  Sean Smart,  Ruth J. Muschel, 
  • Pages: 521-533
  • First Published: 08 April 2015
Free Access

Nuclear factor kappa B–mediated CD47 up-regulation promotes sorafenib resistance and its blockade synergizes the effect of sorafenib in hepatocellular carcinoma in mice

Jessica Lo,  Eunice Yuen Ting Lau,  Rachel Hiu Ha Ching,  Bowie Yik Ling Cheng,  Mark Kin Fai Ma,  Irene Oi Lin Ng,  Terence Kin Wah Lee, 
  • Pages: 534-545
  • First Published: 21 April 2015

Autoimmune, Cholestatic and Biliary Disease

Free Access

Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment

Mala Chakraborty,  Aaron M. Fullerton,  Kenrick Semple,  Lynette S. Chea,  William R. Proctor,  Mohammed Bourdi,  David E. Kleiner,  Xiangbin Zeng,  Pauline M. Ryan,  Pradeep K. Dagur,  Julia D. Berkson,  Timothy P. Reilly,  Lance R. Pohl, 
  • Pages: 546-557
  • First Published: 24 February 2015
Free Access

Targeted pharmacotherapy in progressive familial intrahepatic cholestasis type 2: Evidence for improvement of cholestasis with 4-phenylbutyrate

Emmanuel Gonzales,  Brigitte Grosse,  Brice Schuller,  Anne Davit-Spraul,  Filomena Conti,  Catherine Guettier,  Doris Cassio,  Emmanuel Jacquemin, 
  • Pages: 558-566
  • First Published: 26 February 2015

Liver Failure/Cirrhosis/Portal Hypertension

Free Access

Terlipressin plus albumin versus midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: A randomized trial

Marta Cavallin,  Patrick S. Kamath,  Manuela Merli,  Silvano Fasolato,  Pierluigi Toniutto,  Francesco Salerno,  Mauro Bernardi,  Roberto Giulio Romanelli,  Cosimo Colletta,  Freddy Salinas,  Antonio Di Giacomo,  Lorenzo Ridola,  Ezio Fornasiere,  Paolo Caraceni,  Filippo Morando,  Salvatore Piano,  Angelo Gatta,  Paolo Angeli,  for the Italian Association for the Study of the Liver Study Group on Hepatorenal Syndrome , 
  • Pages: 567-574
  • First Published: 16 January 2015
Free Access

Impact of anticoagulation on upper-gastrointestinal bleeding in cirrhosis. A retrospective multicenter study

Federica Cerini,  Javier Martínez Gonzalez,  Ferran Torres,  Ángela Puente,  Meritxell Casas,  Carmen Vinaixa,  Marina Berenguer,  Alba Ardevol,  Salvador Augustin,  Elba Llop,  Maria Senosiaín,  Càndid Villanueva,  Joaquin de la Peña,  Rafael Bañares,  Joan Genescá,  Júlia Sopeña,  Agustín Albillos,  Jaume Bosch,  Virginia Hernández-Gea,  Juan Carlos Garcia-Pagán, 
  • Pages: 575-583
  • First Published: 12 March 2015
Free Access

Standard assessments of frailty are validated predictors of mortality in hospitalized patients with cirrhosis

Elliot B. Tapper,  Daniel Finkelstein,  Murray A. Mittleman,  Gail Piatkowski,  Michelle Lai, 
  • Pages: 584-590
  • First Published: 04 April 2015

Liver Injury/Regeneration

Open Access

Circulating Kidney Injury Molecule 1 Predicts Prognosis and Poor Outcome in Patients With Acetaminophen-Induced Liver Injury

Daniel J. Antoine,  Venkata S. Sabbisetti,  Ben Francis,  Andrea L. Jorgensen,  Darren G.N. Craig,  Kenneth J. Simpson,  Joseph V. Bonventre,  B. Kevin Park,  James W. Dear, 
  • Pages: 591-599
  • First Published: 18 April 2015
Free Access

Damage-associated molecular pattern–activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

Hai Huang,  Samer Tohme,  Ahmed B. Al-Khafaji,  Sheng Tai,  Patricia Loughran,  Li Chen,  Shu Wang,  Jiyun Kim,  Timothy Billiar,  Yanming Wang,  Allan Tsung, 
  • Pages: 600-614
  • First Published: 08 April 2015

Liver Biology/Pathobiology

Free Access

Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein

Fiona O'Mahony,  Kevin Wroblewski,  Sheila M. O'Byrne,  Hongfeng Jiang,  Kara Clerkin,  Jihane Benhammou,  William S. Blaner,  Simon W. Beaven, 
  • Pages: 615-626
  • First Published: 06 December 2014

Review

Free Access

Strategies and endpoints of antifibrotic drug trials: Summary and recommendations from the AASLD Emerging Trends Conference, Chicago, June 2014

Natalie J. Torok,  Jonathan A. Dranoff,  Detlef Schuppan,  Scott L. Friedman, 
  • Pages: 627-634
  • First Published: 27 January 2015

New Horizons

Free Access

Fibrates and cholestasis

Nisanne S. Ghonem,  David N. Assis,  James L. Boyer, 
  • Pages: 635-643
  • First Published: 11 February 2015

Hepatology Elsewhere

Free Access

Liver regeneration: A consequence of complex, well-orchestrated signals

Thomas D. Shupe PH.D.,  Bryon E. Petersen PH.D., 
  • Pages: 644-645
  • First Published: 07 May 2015
Free Access

Intestinal farnesoid X receptor puts a fresh coat of wax on fatty liver

Iina Tuominen PH.D.,  Simon W. Beaven M.D., PH.D., 
  • Pages: 646-648
  • First Published: 22 May 2015

Clinical Observations in Hepatology

Free Access

A case of granulocyte-colony stimulating factor/plasmapheresis–induced activation of granulocyte-colony stimulating factor–positive hepatic progenitors in acute-on-chronic liver failure

Anna Chiara Piscaglia,  Vincenzo Arena,  Stefano Passalacqua,  Antonio Gasbarrini, 
  • Pages: 649-652
  • First Published: 16 January 2015

Correspondence

Free Access

Lack of difference among vasoconstrictors: Similar effectiveness or similar ineffectiveness?

Gin-Ho Lo M.D., 
  • Page: 653
  • First Published: 06 December 2014
Free Access

Reply

Yeon Seok Seo M.D.,  Chang Ho Jung M.D.,  Tae Hyung Kim M.D.,  Sun Young Yim M.D.,  Soon Ho Um M.D., Ph.D., 
  • Pages: 653-654
  • First Published: 06 December 2014
Free Access

No artifact, hepatitis E is emerging

Hans L. Zaaijer M.D., Ph.D., 
  • Page: 654
  • First Published: 21 November 2014
Free Access

Reply

Jürgen J. Wenzel M.D.,  Wolfgang Jilg M.D., 
  • Page: 654
  • First Published: 21 November 2014
Free Access

A call to action: The need for hepatology-focused educational interventions in Internal Medicine Residency training

Adam E. Mikolajczyk M.D.,  Andrew A. Aronsohn M.D.,  John F. McConville M.D.,  Donald M. Jensen M.D.,  Jeanne M. Farnan M.D., M.H.P.E., 
  • Pages: 655-656
  • First Published: 01 November 2014
Free Access

Difference in Budd-Chiari syndrome between the west and china

Xingshun Qi M.D.,  Xiaozhong Guo M.D., PH.D.,  Daiming Fan M.D., PH.D., 
  • Page: 656
  • First Published: 05 December 2014
Free Access

Reply

Jian-Gao Fan M.D., Ph.D.,  Fu-Sheng Wang M.D., Ph.D., 
  • Page: 657
  • First Published: 05 December 2014
Free Access

Autosis occurs in the liver of patients with severe anorexia nervosa

Marouane Kheloufi M.Sc.,  Chantal M. Boulanger Ph.D.,  Patrice Codogno Ph.D.,  Pierre-Emmanuel Rautou M.D., Ph.D., 
  • Pages: 657-658
  • First Published: 05 November 2014
Free Access

PNPLA3 rs738409 and TM6SF2 rs58542926 gene variants affect renal disease and function in nonalcoholic fatty liver disease

Giovanni Musso M.D.,  Maurizio Cassader PH.D.,  Roberto Gambino PH.D., 
  • Pages: 658-659
  • First Published: 06 December 2014
Free Access

Reply

Stefano Romeo M.D., PH.D.,  Paola Dongiovanni PH.D.,  Salvatore Petta M.D.,  Jussi Pihalajamaki M.D., PH.D.,  Luca Valenti M.D., 
  • Page: 660
  • First Published: 06 December 2014
Free Access

Should patients with hepatitis C genotype 2/3 infection who are slow responders to pegylated interferon/ribavirin have treatment duration extended?

Carla Silva B.S.W. (HONS.),  Elizabeth Ianna C.N.S. R.N.,  Tracey Jones M.NURS. (N.P.), R.N.,  Joshua S. Davis M.B.B.S., F.R.A.C.P., D.T.M.&H.,PH.D., 
  • Pages: 660-661
  • First Published: 07 November 2014