• Issue

    Chirality: Volume 36, Issue 4

    April 2024

ISSUE INFORMATION

Free Access

Issue Information

  • First Published: 21 March 2024

RESEARCH ARTICLES

Open Access

Advantages of a synchrotron light source for fluorescence-detected linear dichroism

  • First Published: 12 April 2024
Advantages of a synchrotron light source for fluorescence-detected linear dichroism

Fluorescence-detected linear dichroism (FD-LD) enables one to collect linear dichroism spectra for oriented fluorophores in the presence of other absorbing species and light scattering. This work uses a synchrotron radiation light source and fluorescence-detection to collect film and flow-oriented FD-LD spectra down to 170 nm.

Novel ethylenediamine-β-cyclodextrin grafted membranes for the chiral separation of mandelic acid and its derivatives

  • First Published: 04 April 2024
Novel ethylenediamine-β-cyclodextrin grafted membranes for the chiral separation of mandelic acid and its derivatives

EDA-β-CD-EPI-CA chiral membrane has unique characteristics on selective separation of enantiomers.

Preparation of amino acid chiral ionic liquid and visual chiral recognition of glutamine and phenylalanine enantiomers

  • First Published: 03 April 2024
Preparation of amino acid chiral ionic liquid and visual chiral recognition of glutamine and phenylalanine enantiomers

Amino acid chiral ionic liquid(AACIL) was successfully prepared and applied as a chiral recognition sensor. The sensor was applied for visual chiral recognition of the enantiomers of glutamine and phenylalanine, and the recognition conditions were optimized. Various methods are used to explore the mechanism of chiral recognition.

Separation of enantiomers of chiral fullerene derivatives through enantioselective encapsulation within an adaptable helical cavity of syndiotactic poly(methyl methacrylate) with helicity memory

  • First Published: 01 April 2024
Separation of enantiomers of chiral fullerene derivatives through enantioselective encapsulation within an adaptable helical cavity of syndiotactic poly(methyl methacrylate) with helicity memory

Optically active left (M)- and right (P)-handed helical syndiotactic poly(methyl methacrylate)s (M- and P-st-PMMAs) prepared by the “helicity induction and memory” strategy enantioselectively encapsulated the racemic fullerene derivatives within their helical cavities to form peapod-like inclusion complexes. Interestingly, the enantiomeric excess (ee) and separation factor (enantioselectivity) (α) of 3,4-fulleroproline tert-butyl ester (rac-1) used as the analyte encapsulated within the helical cavities of the M- and P-st-PMMAs were relatively higher (ee = 23%–25% and α = 2.35–2.50).

RESEARCH ARTICLES

Biocatalytic enantioselective synthesis of cenobamate, an antiepileptic drug

  • First Published: 21 March 2024
Biocatalytic enantioselective synthesis of cenobamate, an antiepileptic drug

A chemo-enzymatic approach has been developed for the first time for the synthesis of the anti-epileptic drug, cenobamate using Daucus carota whole plant cells. The use of commercially readily available vegetables as a source of enzymes makes this method simple, greener, and cost-effective.