• Issue

    Journal of Pharmaceutical Sciences: Volume 99, Issue 7

    2927-3275
    July 2010
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Commentaries

Theoretical versus empirical allometry: Facts behind theories and application to pharmacokinetics†

Iftekhar Mahmood, 
  • Pages: 2927-2933
  • First Published: 01 February 2010

A critical assessment of the ICH guideline on photostability testing of new drug substances and products (Q1B): Recommendation for revision

Steven W. Baertschi,  Karen M. Alsante,  Hanne H. Tønnesen, 
  • Pages: 2934-2940
  • First Published: 04 February 2010

Drug–polymer solubility and miscibility: Stability consideration and practical challenges in amorphous solid dispersion development

Feng Qian,  Jun Huang,  Munir A. Hussain, 
  • Pages: 2941-2947
  • First Published: 01 February 2010

Reviews

The utility of sulfonate salts in drug development

David P. Elder,  Ed Delaney,  Andrew Teasdale,  Steve Eyley,  Van D. Reif,  Karine Jacq,  Kevin L. Facchine,  Rolf Schulte Oestrich,  Patrick Sandra,  Frank David, 
  • Pages: 2948-2961
  • First Published: 28 January 2010

Research Articles

Biotechnology

Buffer-dependent fragmentation of a humanized full-length monoclonal antibody

Branden A. Salinas,  Hasige A. Sathish,  Ambarish U. Shah,  John F. Carpenter,  Theodore W. Randolph, 
  • Pages: 2962-2974
  • First Published: 20 January 2010

Pharmaceutics, Preformulation and Drug Delivery

Conformational polymorphism of tolbutamide: A structural, spectroscopic, and thermodynamic characterization of Burger's forms I–IV

Satyanarayana Thirunahari,  Srinivasulu Aitipamula,  Pui Shan Chow,  Reginald B.H. Tan, 
  • Pages: 2975-2990
  • First Published: 20 January 2010

Effect of low molecular weight chitosans on drug permeation through mouse skin: 1. Transdermal delivery of baicalin

Xueqin Zhou,  Dongzhi Liu,  Haiyan Liu,  Qiaoli Yang,  Kangde Yao,  Xueyan Wang,  Lei Wang,  Xinjian Yang, 
  • Pages: 2991-2998
  • First Published: 20 January 2010

Impact of chlorpromazine self-association on its apparent binding constants with cyclodextrins: Effect of SBE7-β-CD on the disposition of chlorpromazine in the rat

Michelle P. McIntosh,  Nathania Leong,  Kasiram Katneni,  Julia Morizzi,  David M. Shackleford,  Richard J. Prankerd, 
  • Pages: 2999-3008
  • First Published: 20 January 2010

In vivo evaluation of 5-fluorouracil-containing self-expandable nitinol stent in rabbits: Efficiency in long-term local drug delivery†

Sheng-Rong Guo,  Zhong-Min Wang,  Ya-Qiong Zhang,  Lei Lei,  Jing-Min Shi,  Ke-Min Chen,  Zhang Yu, 
  • Pages: 3009-3018
  • First Published: 20 January 2010

Development of mucoadhesive films for buccal administration of flufenamic acid: Effect of cyclodextrin complexation

Paola Mura,  Giovanna Corti,  Marzia Cirri,  Francesca Maestrelli,  Natascia Mennini,  Marco Bragagni, 
  • Pages: 3019-3029
  • First Published: 01 February 2010

Elucidating the pathways of degradation of denagliptin

Biren K. Joshi,  Beverly Ramsey,  Byron Johnson,  Daniel E. Patterson,  Jeremiah Powers,  Kevin L. Facchine,  Martin Osterhout,  Michael P. LeBlanc,  Renetta Bryant-Mills,  Royston C.B. Copley,  Scott L. Sides, 
  • Pages: 3030-3040
  • First Published: 28 January 2010

Effects of insulin-mimetic vanadyl-poly(γ-glutamic acid) complex on diabetic rat model

Rongzhang Hu,  Chengliang He,  Jian Liu,  Yelin Wu,  Jing Li,  Zhen Feng,  Jing Huang,  Xu Guang Xi,  Zirong Wu, 
  • Pages: 3041-3047
  • First Published: 29 January 2010

Molecular dynamics simulations of hydrotropic solubilization and self-aggregation of nicotinamide

Yong Cui,  Chenyue Xing,  Yingqing Ran, 
  • Pages: 3048-3059
  • First Published: 28 January 2010

Drug release from irradiated PLGA and PLLA multi-layered films

Say Chye Joachim Loo,  Zhi Ying Serlin Tan,  Yi Jun Chow,  Siew Ling Ivy Lin, 
  • Pages: 3060-3071
  • First Published: 28 January 2010

Transdermal delivery of naltrexol and skin permeability lifetime after microneedle treatment in hairless guinea pigs

Stan L. Banks,  Raghotham R. Pinninti,  Harvinder S. Gill,  Kalpana S. Paudel,  Peter A. Crooks,  Nicole K. Brogden,  Mark R. Prausnitz,  Audra L. Stinchcomb, 
  • Pages: 3072-3080
  • First Published: 17 February 2010
Free Access

Determination of water penetration and drug concentration profiles in HPMC-based matrix tablets by near infrared chemical imaging

Weiyong Li,  Abraham Woldu,  Lola Araba,  Denita Winstead, 
  • Pages: 3081-3088
  • First Published: 28 January 2010

In vitro reporter gene transfection via plasmid DNA delivered by metered dose inhaler

Baljinder K. Bains,  James C. Birchall,  Richard Toon,  Glyn Taylor, 
  • Pages: 3089-3099
  • First Published: 17 February 2010

Internalization and intracellular trafficking of a PTD-conjugated anti-fibrotic peptide, AZX100, in human dermal keloid fibroblasts

Charles R. Flynn,  Joyce Cheung-Flynn,  Christopher C. Smoke,  David Lowry,  Robert Roberson,  Michael R. Sheller,  Colleen M. Brophy, 
  • Pages: 3100-3121
  • First Published: 05 February 2010

Distribution of doxorubicin in rats undergoing ultrasonic drug delivery

Bryant J. Staples,  William G. Pitt,  Beverly L. Roeder,  Ghaleb A. Husseini,  Deepthi Rajeev,  G. Bruce Schaalje, 
  • Pages: 3122-3131
  • First Published: 17 February 2010

Utilizing a novel tandem oral dosing strategy to enhance exposure of low-solubility drug candidates in a preclinical setting

Po-Chang Chiang,  Sarah A. South,  Kimberly A. Foster,  J. Scott Daniels,  Steve P. Wene,  Lesley A. Albin,  David C. Thompson, 
  • Pages: 3132-3140
  • First Published: 12 March 2010

Pharmaceutical Nanotechnology

Amphiphilic cyclodextrins as nanocarriers of genistein: A spectroscopic investigation pointing out the structural properties of the host/drug complex system

Rosanna Stancanelli,  Marta Guardo,  Carmela Cannavà,  Giovanni Guglielmo,  Paola Ficarra,  Valentina Villari,  Norberto Micali,  Antonino Mazzaglia, 
  • Pages: 3141-3149
  • First Published: 20 January 2010

Templated open flocs of anisotropic particles for pulmonary delivery with pressurized metered dose inhalers

Jasmine M. Tam,  Josh D. Engstrom,  Domingo Ferrer,  Robert O. Williams III,  Keith P. Johnston, 
  • Pages: 3150-3165
  • First Published: 25 February 2010

Pharmaceutical Technology

Complexation of sulfonamides with β-cyclodextrin studied by experimental and theoretical methods

Ariana Zoppi,  Mario A. Quevedo,  Alicia Delrivo,  Marcela R. Longhi, 
  • Pages: 3166-3176
  • First Published: 17 February 2010

Release liner removal method for transdermal drug delivery systems (TDDS)

Anna M. Wokovich,  Meiyu Shen,  William H. Doub,  Stella G. Machado,  Lucinda F. Buhse, 
  • Pages: 3177-3187
  • First Published: 04 February 2010

Freeze-drying in novel container system: Characterization of heat and mass transfer in glass syringes

Sajal M. Patel,  Michael J. Pikal, 
  • Pages: 3188-3204
  • First Published: 17 February 2010

A PAT approach to improve process understanding of high shear wet granulation through in-line particle measurement using FBRM C35

Jun Huang,  Goldi Kaul,  Julia Utz,  Pedro Hernandez,  Victor Wong,  Daragh Bradley,  Arwinder Nagi,  Des O'Grady, 
  • Pages: 3205-3212
  • First Published: 23 February 2010

Modeling of pan coating processes: Prediction of tablet content uniformity and determination of critical process parameters

Wei Chen,  Shih-Ying Chang,  San Kiang,  Alexander Marchut,  Olav Lyngberg,  Jennifer Wang,  Venkatramana Rao,  Divyakant Desai,  Howard Stamato,  William Early, 
  • Pages: 3213-3225
  • First Published: 20 January 2010

Pharmacokinetics, Pharmacodynamics and Drug Metabolism

Examination of the ability of the nasal administration route to confer a brain exposure advantage for three chemical inhibitors of P-glycoprotein

Jeannie M. Padowski,  Gary M. Pollack, 
  • Pages: 3226-3233
  • First Published: 01 February 2010

Prediction of in vivo enantiomeric compositions by modeling in vitro metabolic profiles

Mengmeng Wang,  Qi Wang,  Hong Cai,  Bogdan Sleczka,  Celia D'Arienzo,  Jonathan Josephs,  Xiang-Yang Ye,  Jeffrey Robl,  David Gordon,  David Rodrigues,  Timothy Harper, 
  • Pages: 3234-3245
  • First Published: 28 January 2010

Towards prediction of in vivo intestinal absorption using a 96-well Caco-2 assay

Suzanne Skolnik,  Xuena Lin,  Jianling Wang,  Xiao-Hui Chen,  Timothy He,  Bailin Zhang, 
  • Pages: 3246-3265
  • First Published: 17 February 2010

A novel calmodulin antagonist O-(4-ethoxyl-butyl)-berbamine overcomes multidrug resistance in drug-resistant MCF-7/ADR breast carcinoma cells

Rong Liu,  Yanjun Zhang,  Yanhong Chen,  Jing Qi,  Simei Ren,  Ming Yang Xushi,  Chunzheng Yang,  Huifang Zhu,  Dongsheng Xiong, 
  • Pages: 3266-3275
  • First Published: 28 January 2010