• Issue

    Aging Cell: Volume 15, Issue 6

    983-1153
    December 2016
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Issue Information

Free Access

Issue Information

  • Pages: 983-985
  • First Published: 10 November 2016

Reviews

Open Access

Can aging be programmed? A critical literature review

Axel Kowald,  Thomas B. L. Kirkwood, 
  • Pages: 986-998
  • First Published: 17 August 2016
Open Access

Small molecule compounds that induce cellular senescence

Nadezhda V. Petrova,  Artem K. Velichko,  Sergey V. Razin,  Omar L. Kantidze, 
  • Pages: 999-1017
  • First Published: 14 September 2016

Original Articles

Open Access

A comprehensive approach to the molecular determinants of lifespan using a Boolean model of geroconversion

Loic Verlingue,  Aurélien Dugourd,  Gautier Stoll,  Emmanuel Barillot,  Laurence Calzone,  Arturo Londoño-Vallejo, 
  • Pages: 1018-1026
  • First Published: 09 September 2016
Open Access

Reducing translation through eIF4G/IFG-1 improves survival under ER stress that depends on heat shock factor HSF-1 in Caenorhabditis elegans

Amber C. Howard,  Jarod Rollins,  Santina Snow,  Sarah Castor,  Aric N. Rogers, 
  • Pages: 1027-1038
  • First Published: 18 August 2016
Open Access

Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient

Andrew M. Cobb,  Delphine Larrieu,  Derek T. Warren,  Yiwen Liu,  Sonal Srivastava,  Andrew J. O. Smith,  Richard P. Bowater,  Stephen P. Jackson,  Catherine M. Shanahan, 
  • Pages: 1039-1050
  • First Published: 27 July 2016
Open Access

Alzheimer-related protein APL-1 modulates lifespan through heterochronic gene regulation in Caenorhabditis elegans

Collin Y. Ewald,  Vanessa Marfil,  Chris Li, 
  • Pages: 1051-1062
  • First Published: 24 August 2016
Open Access

hnRNP A1 antagonizes cellular senescence and senescence-associated secretory phenotype via regulation of SIRT1 mRNA stability

Hui Wang,  Limin Han,  Ganye Zhao,  Hong Shen,  Pengfeng Wang,  Zhaomeng Sun,  Chenzhong Xu,  Yuanyuan Su,  Guodong Li,  Tanjun Tong,  Jun Chen, 
  • Pages: 1063-1073
  • First Published: 09 September 2016
Open Access

Short-term calorie restriction ameliorates genomewide, age-related alterations in DNA methylation

Chul Hong Kim,  Eun Kyeong Lee,  Yeon Ja Choi,  Hye Jin An,  Hyeong Oh Jeong,  Daeui Park,  Byoung Chul Kim,  Byung Pal Yu,  Jong Bhak,  Hae Yung Chung, 
  • Pages: 1074-1081
  • First Published: 25 August 2016
Open Access

Exercise reverses age-related vulnerability of the retina to injury by preventing complement-mediated synapse elimination via a BDNF-dependent pathway

Vicki Chrysostomou,  Sandra Galic,  Peter van Wijngaarden,  Ian A. Trounce,  Gregory R. Steinberg,  Jonathan G. Crowston, 
  • Pages: 1082-1091
  • First Published: 09 September 2016
Open Access

SIRT1-mediated ERβ suppression in the endothelium contributes to vascular aging

Danli Kong,  Ying Zhan,  Zhaoyu Liu,  Ting Ding,  Min Li,  Haibing Yu,  Laxi Zhang,  Huawen Li,  Aiyue Luo,  Dongwei Zhang,  Yifei Wang,  Shixuan Wang,  Zhefan Zhang,  Hongyu Zhang,  Xiaodong Huang,  Paul Yao,  Yuanling Ding,  Zhengxiang Liu, 
  • Pages: 1092-1102
  • First Published: 29 July 2016
Open Access

mTORC1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts

Yair Romero,  Marta Bueno,  Remedios Ramirez,  Diana Álvarez,  John C. Sembrat,  Elena A. Goncharova,  Mauricio Rojas,  Moisés Selman,  Ana L. Mora,  Annie Pardo, 
  • Pages: 1103-1112
  • First Published: 26 August 2016
Open Access

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance

Paula Martínez,  Gonzalo Gómez-López,  David G. Pisano,  Juana M. Flores,  Maria A. Blasco, 
  • Pages: 1113-1125
  • First Published: 01 September 2016
Open Access

Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity

Evie van der Spoel,  Steffy W. Jansen,  Abimbola A. Akintola,  Bart E. Ballieux,  Christa M. Cobbaert,  P. Eline Slagboom,  Gerard Jan Blauw,  Rudi G. J. Westendorp,  Hanno Pijl,  Ferdinand Roelfsema,  Diana van Heemst, 
  • Pages: 1126-1131
  • First Published: 07 September 2016
Open Access

Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age

Allen Herbst,  Jonathan Wanagat,  Nashwa Cheema,  Kevin Widjaja,  Debbie McKenzie,  Judd M. Aiken, 
  • Pages: 1132-1139
  • First Published: 25 August 2016
Open Access

Amyloid β-induced astrogliosis is mediated by β1-integrin via NADPH oxidase 2 in Alzheimer's disease

Ane Wyssenbach,  Tania Quintela,  Francisco Llavero,  Jose L. Zugaza,  Carlos Matute,  Elena Alberdi, 
  • Pages: 1140-1152
  • First Published: 05 October 2016

Short Take

Open Access

The NIA interventions testing program announces the 2016 solicitation of proposals

Nancy L. Nadon, 
  • Page: 1153
  • First Published: 10 November 2016