• Issue

    Aging Cell: Volume 11, Issue 6

    921-1134
    December 2012
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Original Articles

Open Access

dFatp regulates nutrient distribution and long-term physiology in Drosophila

Alyson Sujkowski,  Samantha Saunders,  Martin Tinkerhess,  Nicole Piazza,  Joanna Jennens,  Lindsey Healy,  Li Zheng,  Robert Wessells, 
  • Pages: 921-932
  • First Published: 18 July 2012

Brain tissue volumes in familial longevity: the Leiden Longevity Study

Irmhild Altmann-Schneider,  Anton J. M. de Craen,  Pieternella E. Slagboom,  Rudi G. J. Westendorp,  Mark A. van Buchem,  Andrea B. Maier,  Jeroen van der Grond, 
  • Pages: 933-939
  • First Published: 11 August 2012

A comparative assessment of univariate longevity measures using zoological animal records

Jacob A. Moorad,  Daniel E. L. Promislow,  Nate Flesness,  Richard A. Miller, 
  • Pages: 940-948
  • First Published: 17 July 2012

Lnk deficiency partially mitigates hematopoietic stem cell aging

Alexey Bersenev,  Krasimira Rozenova,  Joanna Balcerek,  Jing Jiang,  Chao Wu,  Wei Tong, 
  • Pages: 949-959
  • First Published: 20 July 2012
Open Access

Human serum metabolic profiles are age dependent

Zhonghao Yu,  Guangju Zhai,  Paula Singmann,  Ying He,  Tao Xu,  Cornelia Prehn,  Werner Römisch-Margl,  Eva Lattka,  Christian Gieger,  Nicole Soranzo,  Joachim Heinrich,  Marie Standl,  Elisabeth Thiering,  Kirstin Mittelstraß,  Heinz-Erich Wichmann,  Annette Peters,  Karsten Suhre,  Yixue Li,  Jerzy Adamski,  Tim D. Spector,  Thomas Illig,  Rui Wang-Sattler, 
  • Pages: 960-967
  • First Published: 26 July 2012
Open Access

Age-associated alterations in CD8α+ dendritic cells impair CD8 T-cell expansion in response to an intracellular bacterium

Gang Li,  Megan J. Smithey,  Brian D. Rudd,  Janko Nikolich-Žugich, 
  • Pages: 968-977
  • First Published: 02 August 2012
Open Access

Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain

Hua Bai,  Ping Kang,  Marc Tatar, 
  • Pages: 978-985
  • First Published: 31 August 2012

Modelling in vivo skeletal muscle ageing in vitro using three-dimensional bioengineered constructs

Adam P. Sharples,  Darren J. Player,  Neil R. W. Martin,  Vivek Mudera,  Claire E. Stewart,  Mark P. Lewis, 
  • Pages: 986-995
  • First Published: 08 August 2012
Open Access

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

Diana Jurk,  Chunfang Wang,  Satomi Miwa,  Mandy Maddick,  Viktor Korolchuk,  Avgi Tsolou,  Efstathios S. Gonos,  Christopher Thrasivoulou,  M. Jill Saffrey,  Kerry Cameron,  Thomas von Zglinicki, 
  • Pages: 996-1004
  • First Published: 09 August 2012

Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging

Gautham Yepuri,  Srividya Velagapudi,  Yuyan Xiong,  Angana G. Rajapakse,  Jean-Pierre Montani,  Xiu-Fen Ming,  Zhihong Yang, 
  • Pages: 1005-1016
  • First Published: 29 August 2012

Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice

Antonio Currais,  Marguerite Prior,  David Lo,  Corinne Jolivalt,  David Schubert,  Pamela Maher, 
  • Pages: 1017-1026
  • First Published: 01 September 2012

Increased age of transformed mouse neural progenitor/stem cells recapitulates age-dependent clinical features of human glioma malignancy

Andrei M. Mikheev,  Rohan Ramakrishna,  Elizabeth A. Stoll,  Svetlana A. Mikheeva,  Richard P. Beyer,  David A. Plotnik,  Jeffrey L. Schwartz,  Jason K. Rockhill,  John R. Silber,  Donald E. Born,  Yoshito Kosai,  Philip J. Horner,  Robert C. Rostomily, 
  • Pages: 1027-1035
  • First Published: 07 September 2012

Age-related loss of nitric oxide synthase in skeletal muscle causes reductions in calpain S-nitrosylation that increase myofibril degradation and sarcopenia

Giuseppina Samengo,  Anna Avik,  Brian Fedor,  Daniel Whittaker,  Kyu H. Myung,  Michelle Wehling-Henricks,  James G. Tidball, 
  • Pages: 1036-1045
  • First Published: 05 September 2012

Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids

Deepika Nehra,  Hau D. Le,  Erica M. Fallon,  Sarah J. Carlson,  Dori Woods,  Yvonne A. White,  Amy H. Pan,  Lankai Guo,  Scott J. Rodig,  Jonathan L. Tilly,  Bo R. Rueda,  Mark Puder, 
  • Pages: 1046-1054
  • First Published: 15 September 2012

Stress-associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain

Yixing Han,  Dali Han,  Zheng Yan,  Jerome D. Boyd-Kirkup,  Christopher D. Green,  Philipp Khaitovich,  Jing-Dong J. Han, 
  • Pages: 1055-1064
  • First Published: 15 September 2012

Molecular events in matrix protein metabolism in the aging kidney

Kavithalakshmi Sataranatarajan,  Denis Feliers,  Meenalakshmi M. Mariappan,  Hak Joo Lee,  Myung Ja Lee,  Robert T. Day,  Hima Bindu Yalamanchili,  Goutam G. Choudhury,  Jeffrey L. Barnes,  Holly Van Remmen,  Arlan Richardson,  Balakuntalam S. Kasinath, 
  • Pages: 1065-1073
  • First Published: 30 September 2012

Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue

Nicole H. Rogers,  Alejandro Landa,  Seongjoon Park,  Roy G. Smith, 
  • Pages: 1074-1083
  • First Published: 30 September 2012

Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance

Carmela Matrone,  Siro Luvisetto,  Luca R. La Rosa,  Robert Tamayev,  Annabella Pignataro,  Nadia Canu,  Li Yang,  Alessia P. M. Barbagallo,  Fabrizio Biundo,  Franco Lombino,  Hui Zheng,  Martine Ammassari-Teule,  Luciano D'Adamio, 
  • Pages: 1084-1093
  • First Published: 30 September 2012

Common genetic variants of the β2-adrenergic receptor affect its translational efficiency and are associated with human longevity

Ling Zhao,  Fan Yang,  Ke Xu,  Huiqing Cao,  Gu-Yan Zheng,  Yan Zhang,  Jianxin Li,  Hanbin Cui,  Xiaomin Chen,  Zhiming Zhu,  Hongbo He,  Xianming Mo,  Brian K. Kennedy,  Yousin Suh,  Yi Zeng,  Xiao-Li Tian, 
  • Pages: 1094-1101
  • First Published: 30 September 2012

The transcription factor Sp1 is responsible for aging-dependent altered nucleocytoplasmic trafficking

Sung Y. Kim,  Hyun T. Kang,  Jeong A. Han,  Sang C. Park, 
  • Pages: 1102-1109
  • First Published: 27 September 2012

Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity

Lin Yan,  Ji Yeon Park,  Jean-Guillaume Dillinger,  Mariana S. De Lorenzo,  Chujun Yuan,  Lo Lai,  Chunbo Wang,  David Ho,  Bin Tian,  William C. Stanley,  Johan Auwerx,  Dorothy E. Vatner,  Stephen F. Vatner, 
  • Pages: 1110-1120
  • First Published: 30 September 2012

Short Takes

Chromosome cohesion decreases in human eggs with advanced maternal age

Francesca E. Duncan,  Jessica E. Hornick,  Michael A. Lampson,  Richard M. Schultz,  Lonnie D. Shea,  Teresa K. Woodruff, 
  • Pages: 1121-1124
  • First Published: 23 July 2012

Molecular signatures of long-lived proteins: autolytic cleavage adjacent to serine residues

Shih-Ping Su,  Brian Lyons,  Michael Friedrich,  Jason D. McArthur,  Xiaomin Song,  Dylan Xavier,  Roger J. W. Truscott,  John A. Aquilina, 
  • Pages: 1125-1127
  • First Published: 17 July 2012

Reduced repression of cytokine signaling ameliorates age-induced decline in hematopoietic stem cell function

Gudmundur L. Norddahl,  Martin Wahlestedt,  Santiago Gisler,  Mikael Sigvardsson,  David Bryder, 
  • Pages: 1128-1131
  • First Published: 18 July 2012

Methylation of ELOVL2 gene as a new epigenetic marker of age

Paolo Garagnani,  Maria G. Bacalini,  Chiara Pirazzini,  Davide Gori,  Cristina Giuliani,  Daniela Mari,  Anna M. Di Blasio,  Davide Gentilini,  Giovanni Vitale,  Sebastiano Collino,  Serge Rezzi,  Gastone Castellani,  Miriam Capri,  Stefano Salvioli,  Claudio Franceschi, 
  • Pages: 1132-1134
  • First Published: 12 September 2012