This invited review article describes the adenine model of chronic kidney disease in rodents and compares its features with other rodent models of kidney disease.

This paper provides a balanced and thoughtful review of the management of patients with failing renal allografts, including the discussion relating to the adjustment and timely discontinuation of immunosuppression.

Authors from this paper clearly demonstrated that 5 months of amiloride treatment partially corrected lithium-induced NDI and prevented progression of lithium-induced kidney fibrosis, with a reduction of myofibroblast infiltration and decrease in collagen deposition.

This cross-sectional study does not support the hypothesis that ADPKD patients with end-stage kidney disease have a greater risk of metabolic derangement.

The authors reported a strong cross-sectional association of log2-albuminuria with abdominal obesity, diabetes and microscopic-haem among Indigenous Australian participants who are relatively younger than other populations with chronic kidney disease.

This study investigated the influence of glycans on the activity of the myeloperoxidase enzyme (MPO), and the binding capacity of its physiological inhibitor ceruloplasmin and autoimmune antibodies (MPO-ANCA). Deglycosylated MPO was less antigenic to MPO-ANCA, had less enzymatic activity and did not bind to ceruloplasm. These data demonstrate the importance of MPO glycosylation for its function and role in autoimmune vasculitis.

This study is a national survey to evaluate status of care for controlling cardiovascular risk factors in Thai patients with type 2 diabetes and chronic kidney disease after the development of cardiovascular disease. It has been found that during the era of equal health accessibility in Thailand, most Thai patients with T2DM and CKD, at least stage 3, who had developed CVD could not achieve the therapeutic goals of the established risk factors when treated by physicians. The overall quality of care in these patients was comparable to those from the USA. The national health policy should be designed to improve the quality of care.

This study, although small and uncontrolled, suggests that acceptable rates of remission in primary membranous nephropathy may be achieved using lower cumulative doses of cyclophosphamide compared with usually used current regimens.

This study examined the variability of pre-dialysis troponin values to predict cardiovascular events in 128 HD patients.

Most stable HD patients do not have elevated troponins at baseline.

However, elevated or fluctuating levels are associated with a worse outcome.

Serial troponin measurement has greater sensitivity and higher-negative predictive power compared with a single troponin measurement.

Experimental models of AKI remain poorly understood. Williams et al's comprehensive characterisation of Ischemia/Reperfusion injury, in particular the role of the myeloid cells and epithelial cells, will serve as a valuable reference point for understanding the maladaptive repair processes in this important condition.

In this population-based study from Taiwan, the authors examined the incidence and outcome of non-traumatic lower limb amputation in peritoneal dialysis (PD) and haemodialysis (HD) patients. Diabetic PD patients had a higher risk of amputation than diabetic HD patients, but this association was reversed in non-diabetic patients. Mortality rates after amputation were similar.