The diagnosis of irritable bowel syndrome is a clinical one, and no biomarker differentiates IBS from other organic gastrointestinal diseases. Volatile Organic Compounds analysis has the potential to be a non-invasive biomarker for the diagnosis of irritable bowel syndrome.

Anal acoustic reflectometry and the functional lumen imaging probe are two novel, provocative techniques of anal sphincter function that dynamically assess the anal sphincter during distension. This review details their current and potential future applications whilst highlighting the unanswered questions relevant to these new technologies.

An artificial intelligence platform interpreted FLIP Panometry esophageal motility studies with accuracies of 89% as compared against the impressions of experienced esophagologists.

Our results, if confirmed in a larger, prospective clinical and therapeutic study, demonstrate the usefulness of an up-front evaluation with anxiety questionnaire and esophageal testing in patients with a broad spectrum of upper gastrointestinal symptoms who fail to respond to PPI treatment, supporting the option of alternative treatment modalities.

A retrospective analysis of 57 patients with type II achalasia found that high (>70 mmHg) maximum panesophageal pressurization values on high-resolution-manometry, high 60 mL-fill pressures and spastic-reactive contractile response pattern on FLIP at baseline may predict spasm after treatment.

STING is expressed within the enteric nervous system. While activation of neuronal STING produces IFNβ, enteric glial STING plays a minor role in its production and seems more involved in autophagy processes. Deletion of enteric glial STING does not affect the severity of DSS colitis.

We compared therapeutic responses to two different subsets of EGJOO: major mixed motility disorder (MMMD) and isolated or ineffective EGJOO (IEGJOO) and found that patients with MMMD have greater short-term prognosis and should be considered a different diagnostic classification.

Low molecular extracts from birch, ragweed, and hazel pollen strongly excite enteric and DRG neurons. Nerve activation was mediated by histamine in birch and ragweed, but not in hazel pollen extracts.

Cessation of prucalopride therapy resulted in a loss of initial clinical effect in a large proportion of patients with chronic idiopathic constipation. However, re-treatment with prucalopride after a period of treatment interruption provided a clinical response similar to that of the initial course of therapy.

This natural history study of adults with cyclic vomiting syndrome (CVS) showed ~2/3 reduction in the number of CVS episodes and health care utilization, though ~20% still experienced CVS symptoms at follow-up. This underscores the importance of specialized care and need for targeted therapies.

Our study demonstrates the impact of differing positions (supine, semi-upright, and upright), types of bolus (water, applesauce, and bread), and size of bolus (5 mL, 10 mL, 2 cm, and 4 cm) on HRM metrics on healthy volunteers.

At 24 months, we did not observe large difference in efficacy of GES and G-POEM in medically refractory gastroparesis associated with nausea and vomiting.

Adolescents with IBS have increased Firmicutes and metabolic pathways that include LCFA synthesis. Clostridial species, LCFA synthesis, and saccharolytic pathways decrease after PENFS treatment in females.

Non-constipated, LFD-responsive IBS patients reintroduced to different solutions (glucose/fructose/glucose + fructose) in increasing dosages up to 15 g demonstrated no significant difference in mean sugar dose tolerated, suggesting fructose reintroduction should use doses >15 g to assess tolerance. LFD was associated with significant changes in microbial composition and bacterial genes involved in FODMAP metabolism.

Although the use of a footstool during defecation changes the degree of hip flexion in the toileting position, we found that it does not improve the subjective or objective measures of simulated defecation in patients with undifferentiated constipation. Therefore, the recommendation for its use may not be applicable to all patients presenting with constipation.