We found that numbers of pDCs, Tregs and ICOS+ Tregs in peripheral blood were increased in GC patients compared with healthy donors. In tissue, Tregs and ICOS+ Tregs were found distributing mainly in carcinoma tissue, while pDCs mainly in peritumor tissue. Both pDCs and ICOS+ Tregs participate in the immunosuppression microenviroment of gastric cancer together.

The combination of GITR mAb and IFN-α gene therapy could be a promising therapeutic strategy for pancreatic cancer.

An N-terminal fragment of the laminin gamma2 chain retracts vascular endothelial cells by inducing delocalization of VE-cadherin.

Serum MIC1 may serve as a diagnostic marker and an independent prognostic factor for ESCC. Additionally,monitoring of serum MIC1 after surgery is useful in evaluation of early recurrence. Notably, this study highlights that the over-expression of MIC1 was associated with lymph node metastasis and MIC1 can act as a therapeutic target for antibody-based therapy in the treatment of ESCC.

APE1-siRNA markedly inhibited tumor angiogenesis by down-regulating FGF2/FGFR3 in vitro and in vivo. Therefore, the APE1-FGF2/FGFR3 pathway identified in this study may be a valuable molecular target for osteosarcoma therapy.

Bortezomib therapy-related lung disease in Japanese patients with multiple myeloma: Incidence, mortality, and clinical characterization (radiographic pattern).

There is a demand for effective molecular target drugs for esophageal cancer that combine an improved therapeutic efficacy with fewer adverse effects. Esophageal squamous cell carcinoma cell lines were screened with recently developed PARP inhibitors and a specific cell line, TE-6 exhibited better sensitivity.

The type III Epstein-Barr virus (EBV) latency in B lymphoma cells augments the cytolytic activity of measles virus. This is attributed to the up-regulation of CD150 by EBV-encoded oncoprotein LMP1.

Doxorubicin-induced EMT reduced the chemotherapeutic effect of doxorubicin treatment in bladder cancer cells. GC7, which inhibited activity of eIF5A2, sensitized bladder cancer cells to doxorubicin via preventing EMT. Combined treatment of GC7 and doxorubicin provides a new insight to clinic bladder cancer therapy.

MicroRNA-143 regulates the collagen type III expression through activation of transforming growth factor-β/SMAD pathway in stromal fibroblasts of scirrhous type gastric cancer.

miR-148a expression was significantly downregulated in gastric cancer, and its downregulation was significantly correlated with an worse clinico-pathologic characters. MMP7 was found to be a direct and functional target of miR-148a, participating in cell invasion.