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Improving Consistency and Understanding of Discrepancies of Findings from Pharmacoepidemiological Studies: the IMI PROTECT Project

Issue Information

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Issue Information

  • Pages: 1-4
  • First Published: 01 April 2016

Introduction

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The IMI PROTECT project: purpose, organizational structure, and procedures

Robert F. Reynolds,  Xavier Kurz,  Mark C.H. de Groot,  Raymond G. Schlienger,  Lamiae Grimaldi-Bensouda,  Stephanie Tcherny-Lessenot,  Olaf H. Klungel, 
  • Pages: 5-10
  • First Published: 01 April 2016

Original Reports

Open Access

Prevalence of antibiotic use: a comparison across various European health care data sources

Ruth Brauer,  Ana Ruigómez,  Gerry Downey,  Andrew Bate,  Luis Alberto Garcia Rodriguez,  Consuelo Huerta,  Miguel Gil,  Francisco de Abajo,  Gema Requena,  Yolanda Alvarez,  Jim Slattery,  Mark de Groot,  Patrick Souverein,  Ulrik Hesse,  Marietta Rottenkolber,  Sven Schmiedl,  Frank de Vries,  Maurille Feudjo Tepie,  Raymond Schlienger,  Liam Smeeth,  Ian Douglas,  Robert Reynolds,  Olaf Klungel, 
  • Pages: 11-20
  • First Published: 07 July 2015
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Validity of diagnostic codes and laboratory measurements to identify patients with idiopathic acute liver injury in a hospital database

Renate Udo,  Anke H. Maitland-van der Zee,  Toine C. G. Egberts,  Johanna H. den Breeijen,  Hubert G. M. Leufkens,  Wouter W. van Solinge,  Marie L. De Bruin, 
  • Pages: 21-28
  • First Published: 05 July 2015
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Risk of acute liver injury associated with use of antibiotics. Comparative cohort and nested case–control studies using two primary care databases in Europe

Ruth Brauer,  Ian Douglas,  Luis Alberto Garcia Rodriguez,  Gerald Downey,  Consuelo Huerta,  Francisco de Abajo,  Andrew Bate,  Maurille Feudjo Tepie,  Mark C. H. de Groot,  Raymond Schlienger,  Robert Reynolds,  Liam Smeeth,  Olaf Klungel,  Ana Ruigómez, 
  • Pages: 29-38
  • First Published: 01 April 2016
Open Access

The risk of acute liver injury among users of antibiotic medications: a comparison of case-only studies.

Ruth Brauer,  Ana Ruigómez,  Olaf Klungel,  Robert Reynolds,  Maurille Feudjo Tepie,  Liam Smeeth,  Ian Douglas, 
  • Pages: 39-46
  • First Published: 06 August 2015
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The risk of acute liver injury associated with the use of antibiotics—evaluating robustness of results in the pharmacoepidemiological research on outcomes of therapeutics by a European consortium (PROTECT) project.

Renate Udo,  Stéphanie Tcherny-Lessenot,  Ruth Brauer,  Paul Dolin,  David Irvine,  Yunxun Wang,  Laurent Auclert,  Juhaeri Juhaeri,  Xavier Kurz,  Lucien Abenhaim,  Lamiae Grimaldi,  Marie L. De Bruin, 
  • Pages: 47-55
  • First Published: 02 August 2015
Free Access

Exposure to benzodiazepines (anxiolytics, hypnotics and related drugs) in seven European electronic healthcare databases: a cross-national descriptive study from the PROTECT-EU Project

Consuelo Huerta,  Victoria Abbing-Karahagopian,  Gema Requena,  Belén Oliva,  Yolanda Alvarez,  Helga Gardarsdottir,  Montserrat Miret,  Cornelia Schneider,  Miguel Gil,  Patrick C. Souverein,  Marie L. De Bruin,  Jim Slattery,  Mark C. H. De Groot,  Ulrik Hesse,  Marietta Rottenkolber,  Sven Schmiedl,  Dolores Montero,  Andrew Bate,  Ana Ruigomez,  Luis Alberto García-Rodríguez,  Saga Johansson,  Frank de Vries,  Raymond G. Schlienger,  Robert F. Reynolds,  Olaf H. Klungel,  Francisco José de Abajo, 
  • Pages: 56-65
  • First Published: 07 July 2015
Free Access

Hip/femur fractures associated with the use of benzodiazepines (anxiolytics, hypnotics and related drugs): a methodological approach to assess consistencies across databases from the PROTECT-EU project

Gema Requena,  Consuelo Huerta,  Helga Gardarsdottir,  John Logie,  Rocío González-González,  Victoria Abbing-Karahagopian,  Montserrat Miret,  Cornelia Schneider,  Patrick C. Souverein,  Dave Webb,  Ana Afonso,  Nada Boudiaf,  Elisa Martin,  Belén Oliva,  Arturo Alvarez,  Mark C. H. De Groot,  Andrew Bate,  Saga Johansson,  Raymond Schlienger,  Robert Reynolds,  Olaf H. Klungel,  Francisco J. de Abajo, 
  • Pages: 66-78
  • First Published: 23 June 2015
Open Access

Do case-only designs yield consistent results across design and different databases? A case study of hip fractures and benzodiazepines

Gema Requena,  John Logie,  Elisa Martin,  Nada Boudiaf,  Rocío González González,  Consuelo Huerta,  Arturo Alvarez,  David Webb,  Andrew Bate,  Luis A. García Rodríguez,  Robert Reynolds,  Raymond Schlienger,  Helga Gardarsdottir,  Mark de Groot,  Olaf H. Klungel,  Fancisco de Abajo,  Ian J. Douglas, 
  • Pages: 79-87
  • First Published: 26 June 2015
Free Access

Understanding inconsistency in the results from observational pharmacoepidemiological studies: the case of antidepressant use and risk of hip/femur fractures

Patrick C. Souverein,  Victoria Abbing-Karahagopian,  Elisa Martin,  Consuelo Huerta,  Francisco de Abajo,  Hubert G. M. Leufkens,  Gianmario Candore,  Yolanda Alvarez,  Jim Slattery,  Montserrat Miret,  Gema Requena,  Miguel J. Gil,  Rolf H. H. Groenwold,  Robert Reynolds,  Raymond G. Schlienger,  John W. Logie,  Mark C. H. de Groot,  Olaf H. Klungel,  Tjeerd P. van Staa,  Toine C. G. Egberts,  Marie L. De Bruin,  Helga Gardarsdottir, 
  • Pages: 88-102
  • First Published: 01 April 2016
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Case-only designs for studying the association of antidepressants and hip or femur fracture

Mark C. H. de Groot,  Gianmario Candore,  Md. Jamal Uddin,  Patrick C. Souverein,  M. Sanni Ali,  Svetlana V. Belitser,  Consuelo Huerta,  Rolf H. H. Groenwold,  Yolanda Alvarez,  Jim Slattery,  Joke Korevaar,  Arno W. Hoes,  Kit C. B. Roes,  Anthonius de Boer,  Ian J. Douglas,  Raymond G. Schlienger,  Robert Reynolds,  Olaf H. Klungel,  Helga Gardarsdottir, 
  • Pages: 103-113
  • First Published: 01 April 2016
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Methodological comparison of marginal structural model, time-varying Cox regression, and propensity score methods: the example of antidepressant use and the risk of hip fracture

M. Sanni Ali,  Rolf H. H. Groenwold,  Svetlana V. Belitser,  Patrick C. Souverein,  Elisa Martín,  Nicolle M. Gatto,  Consuelo Huerta,  Helga Gardarsdottir,  Kit C. B. Roes,  Arno W. Hoes,  Antonius de Boer,  Olaf H. Klungel, 
  • Pages: 114-121
  • First Published: 01 April 2016
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Instrumental variables analysis using multiple databases: an example of antidepressant use and risk of hip fracture

Md Jamal Uddin,  Rolf H. H. Groenwold,  Anthonius de Boer,  Helga Gardarsdottir,  Elisa Martin,  Gianmario Candore,  Svetlana V. Belitser,  Arno W. Hoes,  Kit C. B. Roes,  Olaf H. Klungel, 
  • Pages: 122-131
  • First Published: 01 April 2016
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Evaluating different physician's prescribing preference based instrumental variables in two primary care databases: a study of inhaled long-acting beta2-agonist use and the risk of myocardial infarction

Md. Jamal Uddin,  Rolf H. H. Groenwold,  Anthonius de Boer,  Ana S. M. Afonso,  Paola Primatesta,  Claudia Becker,  Svetlana V. Belitser,  Arno W. Hoes,  Kit C. B. Roes,  Olaf H. Klungel, 
  • Pages: 132-141
  • First Published: 01 April 2016
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Impact of varying outcomes and definitions of suicidality on the associations of antiepileptic drugs and suicidality: comparisons from UK Clinical Practice Research Datalink (CPRD) and Danish national registries (DNR)

Markus Schuerch,  Christiane Gasse,  Noah Jamie Robinson,  Yolanda Alvarez,  Robert Walls,  Ole Mors,  Jakob Christensen,  Ulrik Hesse,  Mark de Groot,  Raymond Schlienger,  Robert Reynolds,  Olaf Klungel,  Frank de Vries, 
  • Pages: 142-155
  • First Published: 01 April 2016

Summary

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Multi-centre, multi-database studies with common protocols: lessons learnt from the IMI PROTECT project

Olaf H. Klungel,  Xavier Kurz,  Mark C. H. de Groot,  Raymond G. Schlienger,  Stephanie Tcherny-Lessenot,  Lamiae Grimaldi,  Luisa Ibáñez,  Rolf H. H. Groenwold,  Robert F. Reynolds, 
  • Pages: 156-165
  • First Published: 01 April 2016