• Issue

    Molecular Carcinogenesis: Volume 63, Issue 3

    357-548
    March 2024

ISSUE INFORMATION

Free Access

Issue Information - Ed Board

  • Pages: 357-359
  • First Published: 02 February 2024

RESEARCH ARTICLES

Cancer-associated fibroblasts promote stemness maintenance and gemcitabine resistance via HIF-1α/miR-21 axis under hypoxic conditions in pancreatic cancer

  • Pages: 524-537
  • First Published: 10 January 2024
Cancer-associated fibroblasts promote stemness maintenance and gemcitabine resistance via HIF-1α/miR-21 axis under hypoxic conditions in pancreatic cancer

Hypoxia promotes CAFs to secrete high-level miR-21 EVs through the HIF-1α/miR-21 axis, and activates the miR-21/RAS/AKT/ERK pathway via EVs to trigger stemness maintenance and GEM resistance in PC.