Pain: From Genes and Proteins to Cells in the Living Organism: Journal of Neuroscience Research: Vol 95, No 6

In most animal studies of neuropathic pain following spinal cord injury (SCI), behavioral assessments ignore affect. Consequently, reported pain may be merely SCI-associated hyperreflexia. Clinically, the affective component of pain dominates but is subjective. Additional progress depends on iterations of objective measures in a bench-to-bedside-and-back approach.

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α5GABA_A Receptors Mediate Tonic Inhibition in the Spinal Cord Dorsal Horn and Contribute to the Resolution Of Hyperalgesia

Jimena Perez-Sanchez, Louis-Etienne Lorenzo, Irene Lecker, Agnieszka A. Zurek, Charalampos Labrakakis, Erica M. Bridgwater, Beverley A. Orser, Yves De Koninck, Robert P. Bonin,

Pages: 1307-1318
First Published: 28 October 2016

α5GABAA Receptors Mediate Tonic Inhibition in the Spinal Cord Dorsal Horn and Contribute to the Resolution Of Hyperalgesia

This study reveals that α5GABA_ARs generate a tonic inhibitory conductance in neurons of the spinal cord dorsal horn and regulate the resolution of hyperalgesia. Gabra5−/− mice show a normal degree of mechanical hypersensitivity immediately after peripheral insult but take longer to return to baseline responsiveness. These findings suggest that enhancing tonic inhibition through α5GABA_ARs receptors may accelerate recovery after a sensitizing insult.

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P2 receptors, microglial cytokines and chemokines, and neuropathic pain

Makoto Tsuda,

Pages: 1319-1329
First Published: 04 July 2016

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Topography of microglial activation in sensory- and affect-related brain regions in chronic pain

Anna M.W. Taylor, Sadaf Mehrabani, Steve Liu, Alison J. Taylor, Catherine M. Cahill,

Pages: 1330-1335
First Published: 30 August 2016

Topography of microglial activation in sensory- and affect-related brain regions in chronic pain

A peripheral nerve injury induces widespread microglial activation in brain regions associated with pain and affect. Activation was generally more pronounced on the contralateral side, corresponding to the region receiving input from injured afferents.

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The noradrenergic locus coeruleus as a chronic pain generator

Bradley K. Taylor, Karin N. Westlund,

Pages: 1336-1346
First Published: 29 September 2016

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From blast to bench: A translational mini-review of posttraumatic headache

Laura S. Moye, Amynah A. Pradhan,

Pages: 1347-1354
First Published: 02 February 2017

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Journal of Neuroscience Research: Volume 95, Issue 6

Special Issue:Pain: From Genes and Proteins to Cells in the Living Organism

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