COVER ILLUSTRATION: Locked-in Children. Children resuscitated after near-fatal drowning often incur anoxic brain injury (ABI). Locked-in syndrome — a condition defined by the co-occurrence of quadriplegia and aphonia — is a previously unreported consequence of pediatric ABI. In this issue, Ishaque and colleagues report ICA analysis of resting-state fMRI (rs-fMRI) and network-based quantitative behavioral assessments in 10 children with drowning-induced ABI, each of whom exhibit some form of lockedin syndrome. On a per-subject basis, rs-fMRI network preservation closely paralleled behavioral results (r = 0.74), suggesting that rs-fMRI has the potential to assess cognitive status when communication is compromised.