• Issue

    American Journal of Hematology: Volume 98, Issue 12

    1821-1966, E349-E410
    December 2023
Previous Issue|Next Issue
Export Citation(s)Download PDF(s)

ISSUE INFORMATION

Free Access

Issue Information

  • Pages: 1821-1823
  • First Published: 14 November 2023

EDITORIAL PERSPECTIVES

Free Access

Increased risk of venous thromboembolism in patients with gastrointestinal disorders

Ying X. Gue,  Gregory Y. H. Lip, 
  • Pages: 1824-1825
  • First Published: 19 October 2023
Free Access

Crude lymphocyte levels: Can the past accelerate the future in preventive medicine?

David A. Zidar, 
  • Pages: 1826-1828
  • First Published: 14 October 2023

RESEARCH ARTICLES

Open Access

A globally applicable “triple A” risk model for essential thrombocythemia based on Age, Absolute neutrophil count, and Absolute lymphocyte count

Ayalew Tefferi,  Giuseppe G. Loscocco,  Faiqa Farrukh,  Natasha Szuber,  Francesco Mannelli,  Animesh Pardanani,  Curtis A. Hanson,  Rhett P. Ketterling,  Valerio De Stefano,  Alessandra Carobbio,  Tiziano Barbui,  Paola Guglielmelli,  Naseema Gangat,  Alessandro M. Vannucchi, 
  • Pages: 1829-1837
  • First Published: 04 September 2023
A globally applicable “triple A” risk model for essential thrombocythemia based on Age, Absolute neutrophil count, and Absolute lymphocyte count

The prognostic contribution of Age, Absolute neutrophil, and Absolute lymphocyte counts, on survival in essential thrombocythemia. A new 4-tiered (AAA; triple A) risk model: high (median survival 8 years), intermediate-2 (13.5 years), intermediate-1 (20.7 years), and low (47 years).

Free Access

Effects of 2,3-DPG knockout on SCD phenotype in Townes SCD model mice

Amey Barakat,  Reema Jasuja,  Lindsay Tomlinson,  Zane Wenzel,  Lila Ramaiah,  Betty A. Petterson,  Brendon Kapinos,  Anagha Sawant,  Vicente Pagan,  Nathanael Lintner,  Denise Field,  Youngwook Ahn,  Kelly M. Knee, 
  • Pages: 1838-1846
  • First Published: 09 September 2023
Free Access

Measurable residual disease monitoring in patients with acute myeloid leukemia treated with lower-intensity therapy: Roadmap from an ELN-DAVID expert panel

Farhad Ravandi,  Jacqueline Cloos,  Francesco Buccisano,  Richard Dillon,  Konstanze Döhner,  Sylvie D. Freeman,  Christopher S. Hourigan,  Gerrit J. Ossenkoppele,  Gail J. Roboz,  Marion Subklewe,  Christian Thiede,  Isabell Arnhardt,  Peter J. M. Valk,  Adriano Venditti,  Andrew H. Wei,  Roland B. Walter,  Michael Heuser, 
  • Pages: 1847-1855
  • First Published: 06 September 2023
Open Access

The evolving landscape of COVID-19 and post-COVID condition in patients with chronic lymphocytic leukemia: A study by ERIC, the European research initiative on CLL

Andrea Visentin,  Thomas Chatzikonstantinou,  Lydia Scarfò,  Anargyros Kapetanakis,  Christos Demosthenous,  Georgios Karakatsoulis,  Eva Minga,  Dimitra Chamou,  David Allsup,  Alejandro Alonso Cabrero,  Martin Andres,  Darko Antic,  Mónica Baile,  Panagiotis Baliakas,  Sotiria Besikli-Dimou,  Dominique Bron,  Sofia Chatzileontiadou,  Raul Cordoba,  Juan-Gonzalo Correa,  Carolina Cuéllar-García,  Lorenzo De Paoli,  Maria Rosaria De Paolis,  Julio Delgado,  Maria Dimou,  David Donaldson,  Mark Catherwood,  Michael Doubek,  Maria Efstathopoulou,  Barbara Eichhorst,  Salma Elashwah,  Alicia Enrico,  Blanca Espinet,  Lucia Farina,  Angela Ferrari,  Myriam Foglietta,  Henrik Frederiksen,  Moritz Fürstenau,  José A. García-Marco,  Rocío García-Serra,  Rosa Collado,  Massimo Gentile,  Eva Gimeno,  Andreas Glenthøj,  Maria Gomes da Silva,  Yervand K. Hakobyan,  Yair Herishanu,  José Ángel Hernández-Rivas,  Tobias Herold,  Idanna Innocenti,  Gilad Itchaki,  Ozren Jaksic,  Ann Janssens,  Оlga B. Kalashnikova,  Elżbieta Kalicińska,  Arnon P. Kater,  Sabina Kersting,  Jorge Labrador,  Deepesh Lad,  Luca Laurenti,  Mark-David Levin,  Enrico Lista,  Alberto Lopez-Garcia,  Lara Malerba,  Roberto Marasca,  Monia Marchetti,  Juan Marquet,  Mattias Mattsson,  Francesca R. Mauro,  Marta Morawska,  Marina Motta,  Talha Munir,  Roberta Murru,  Carsten U. Niemann,  Raquel Nunes Rodrigues,  Jacopo Olivieri,  Lorella Orsucci,  Maria Papaioannou,  Miguel Arturo Pavlovsky,  Inga Piskunova,  Viola Maria Popov,  Francesca Maria Quaglia,  Giulia Quaresmini,  Kristian Qvist,  Gian Matteo Rigolin,  Rosa Ruchlemer,  Martin Šimkovič,  Martin Špaček,  Paolo Sportoletti,  Oana Stanca,  Tamar Tadmor,  Antonella Capasso,  Giovanni Del Poeta,  Odit Gutwein,  Linda Katharina Karlsson,  Ivana Milosevic,  Fatima Mirás,  Gianluigi Reda,  Gevorg Saghumyan,  Amit Shrestha,  Doreen Te Raa,  Sanne H. Tonino,  Ellen Van Der Spek,  Michel van Gelder,  Roel van Kampen,  Ewa Wasik-Szczepanek,  Tomasz Wróbel,  Lucrecia Yáñez San Segundo,  Mohamed Yassin,  Barbara Pocali,  Elisabeth Vandenberghe,  Sunil Iyengar,  Marzia Varettoni,  Candida Vitale,  Marta Coscia,  Alessandro Rambaldi,  Emili Montserrat,  Antonio Cuneo,  Niki Stavroyianni,  Livio Trentin,  Kostas Stamatopoulos,  Paolo Ghia, 
  • Pages: 1856-1868
  • First Published: 29 September 2023
Free Access

Prospective analysis to determine barriers to allogeneic hematopoietic cell transplantation in patients with acute leukemia

Karthik Nath,  Jasme Lee,  Theresa A. Elko,  Lauren Levy,  Elaina Preston,  Sean M. Devlin,  Doris M. Ponce,  Richard J. Lin,  Brian C. Shaffer,  Christina Cho,  Ioannis Politikos,  Ann A. Jakubowski,  Jae H. Park,  Raajit Rampal,  Miguel-Angel Perales,  Martin S. Tallman,  Juliet N. Barker,  Ellin Berman,  Roni Tamari,  Eytan Stein,  Sergio A. Giralt,  Boglarka Gyurkocza, 
  • Pages: 1869-1876
  • First Published: 09 September 2023
Open Access

A novel missense variant in ATP11C is associated with reduced red blood cell phosphatidylserine flippase activity and mild hereditary hemolytic anemia

Myrthe J. van Dijk,  Brigitte A. van Oirschot,  Alexander N. Harrison,  Steffen M. Recktenwald,  Min Qiao,  Amaury Stommen,  Anne-Sophie Cloos,  Juliette Vanderroost,  Romano Terrasi,  Kuntal Dey,  Jennifer Bos,  Minke A. E. Rab,  Anna Bogdanova,  Giampaolo Minetti,  Giulio G. Muccioli,  Donatienne Tyteca,  Stéphane Egée,  Lars Kaestner,  Robert S. Molday,  Eduard J. van Beers,  Richard van Wijk, 
  • Pages: 1877-1887
  • First Published: 06 September 2023
A novel missense variant in ATP11C is associated with reduced red blood cell phosphatidylserine flippase activity and mild hereditary hemolytic anemia

ATP11C deficiency is associated with reduced red blood cell flippase activity and increased phosphatidylserine surface exposure

Free Access

Bone marrow fibrosis is associated with non-response to CD19 CAR T-cell therapy in B-acute lymphoblastic leukemia

Joshua Anil,  Ahab Alnemri,  Andrew Lytle,  Brian Lockhart,  Ashley E. Anil,  Michael Baumgartner,  Kirubel Gebre,  Jared McFerran,  Stephan A. Grupp,  Susan R. Rheingold,  Vinodh Pillai, 
  • Pages: 1888-1897
  • First Published: 18 September 2023
Free Access

Analysis of 60 patients with relapsed or refractory T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma treated with CD7-targeted chimeric antigen receptor-T cell therapy

Xian Zhang,  Junfang Yang,  Jingjing Li,  Liyuan Qiu,  Jianping Zhang,  Yue Lu,  Yan-li Zhao,  David Jin,  Jianqiang Li,  Peihua Lu, 
  • Pages: 1898-1908
  • First Published: 23 September 2023

Open Access

Immune cell kinetics and antibody response in COVID-19 patients with low-count monoclonal B-cell lymphocytosis

Guillermo Oliva-Ariza,  Blanca Fuentes-Herrero,  Quentin Lecrevisse,  Cristina Carbonell,  Alba Pérez-Pons,  Alba Torres-Valle,  Julio Pozo,  José Ángel Martín-Oterino,  Óscar González-López,  Amparo López-Bernús,  Marta Bernal-Ribes,  Moncef Belhassen-García,  Oihane Pérez-Escurza,  Martín Pérez-Andrés,  Lourdes Vazquez,  Guillermo Hernández-Pérez,  Francisco Javier García Palomo,  Pilar Leoz,  Pilar Costa-Alba,  Elena Pérez-Losada,  Ana Yeguas,  Miryam Santos Sánchez,  Marta García-Blázquez,  F. Javier Morán-Plata,  Daniela Damasceno,  Vitor Botafogo,  Noemí Muñoz-García,  Rafael Fluxa,  Jacques J. M. van Dongen,  Miguel Marcos,  Julia Almeida,  Alberto Orfao, on behalf of the ECRIN-M3 Consortium , 
  • Pages: 1909-1922
  • First Published: 04 October 2023
Open Access

Erythropoietin downregulates red blood cell clearance, increasing transfusion efficacy in severely anemic recipients

Madeleine Casimir,  Martin Colard,  Michael Dussiot,  Camille Roussel,  Anaïs Martinez,  Carole Peyssonnaux,  Patrick Mayeux,  Samantha Benghiat,  Sandra Manceau,  Anne Francois,  Nathalie Marin,  Frédéric Pène,  Pierre A. Buffet,  Olivier Hermine,  Pascal Amireault, 
  • Pages: 1923-1933
  • First Published: 04 October 2023

ANNUAL CLINICAL UPDATES IN HEMATOLOGICAL MALIGNANCIES

Open Access

POEMS syndrome: Update on diagnosis, risk-stratification, and management

Angela Dispenzieri, 
  • Pages: 1934-1950
  • First Published: 21 September 2023

CLINICAL PEARLS IN BLOOD DISEASES

MORPHOLOGY UPDATE

Open Access

Hematological features of scrub typhus

Biswadip Hazarika,  Neelam Khanna,  Barbara J. Bain, 
  • Pages: 1951-1952
  • First Published: 30 August 2023

CLINICAL PROBLEM SOLVING

Open Access

Severe autoimmune heparin-induced thrombocytopenia postcardiac surgery: Implications for subsequent cardiac surgery

Khalid Al-Azri,  Kate Goldstone,  Julia Phillips,  Jack Bhana,  Nishith Patel,  Theodore E. Warkentin, 
  • Pages: 1953-1958
  • First Published: 12 October 2023

IMAGES IN HEMATOLOGY

Free Access

Concomitant myeloproliferative neoplasm with eosinophilia, B and T cell lymphoblastic lymphoma/leukemia and mast cell proliferation driven by ZMYM2::FGFR1 rearrangement

Giuseppe G. Loscocco,  Stefano Ascani,  Francesco Mannelli,  Magda Zanelli,  Giada Rotunno,  Raffaella Santi,  Alessandro M. Vannucchi, 
  • Pages: 1959-1962
  • First Published: 12 July 2023

DIAGNOSTIC IMAGING IN HEMATOLOGY

Open Access

Microvascular cardiac amyloidosis–Cardiac involvement of amyloidosis presenting as typical chest pain

Iuliana Vaxman,  Caroline Kaufman,  Amir Lerman,  Morie A. Gertz, 
  • Pages: 1963-1966
  • First Published: 25 October 2023
Microvascular cardiac amyloidosis–Cardiac involvement of amyloidosis presenting as typical chest pain

Coronary microvascular angina from cardiac amyloidosis.

CORRESPONDENCES

Free Access

Increased risk of infection reporting with anti-BCMA bispecific monoclonal antibodies in multiple myeloma: A worldwide pharmacovigilance study

Adrien Contejean,  Cécile Janssen,  Frédérique Orsini-Piocelle,  Céline Zecchini,  Caroline Charlier,  Laurent Chouchana, 
  • Pages: E349-E353
  • First Published: 30 August 2023
Increased risk of infection reporting with anti-BCMA bispecific monoclonal antibodies in multiple myeloma: A worldwide pharmacovigilance study

Free Access

Acute myeloid leukemia with mutated TP53: Is this newly proposed entity oversimplifying a complex group of neoplasms?

Hong Fang,  L. Jeffery Medeiros,  Wei Wang, 
  • Pages: E354-E355
  • First Published: 08 September 2023
Free Access

Chronic GvHD in a prognostic model: Graft versus leukemia predictor or immortal time bias?

Erik G. J. von Asmuth,  Arjan C. Lankester,  Hein Putter, 
  • Page: E356
  • First Published: 15 September 2023
Open Access

Patients with telomere biology disorders show context specific somatic mosaic states with high frequency of U2AF1 variants

Alejandro Ferrer,  Terra Lasho,  Jenna A. Fernandez,  Nickolas P. Steinauer,  Rachel A. Simon,  Christy M. Finke,  Eva M. Carmona,  Mark E. Wylam,  Laura J. Ongie,  Brittany N. Burnap,  Cecilia Arana Yi,  Lisa Z. Sproat,  James Foran,  Talha Badar,  Abhishek A. Mangaonkar,  Mrinal M. Patnaik, 
  • Pages: E357-E359
  • First Published: 04 September 2023
Patients with telomere biology disorders show context specific somatic mosaic states with high frequency of U2AF1 variants

Somatic mosaic states in telomere biology disorders are characterized by somatic variants in the spliceosome and DNA damage response and repair pathways. A likely maladaptive response to short telomeres that may lead to increased hematological cancer.

Free Access

Drivers of deep molecular response and long-term outcomes in patients with core binding factor acute myeloid leukemia

Parth C. Patel,  Somedeb Ball,  Akriti G. Jain,  Chen Wang,  Mohammad O. Hussaini,  Luis E. Aguirre,  Onyee Chan,  Seongseok Yun,  Andrew Kuykendall,  Eric Padron,  Kendra Sweet,  Jeffrey E. Lancet,  Rami S. Komrokji,  David A. Sallman, 
  • Pages: E360-E363
  • First Published: 13 September 2023
Drivers of deep molecular response and long-term outcomes in patients with core binding factor acute myeloid leukemia

A swimmer plot on clinical course of patients undergoing allogeneic stem cell transplant for core binding factor acute myeloid leukemia.

Open Access

The FLT3N701K mutation causes clinical AML resistance to gilteritinib and triggers TKI sensitivity switch to quizartinib

Sunil K. Joshi,  Janét Pittsenbarger,  Vanessa E. Kennedy,  Cheryl A. C. Peretz,  Alexander E. Perl,  Catherine C. Smith,  Jeffrey W. Tyner,  Brian J. Druker,  Elie Traer, 
  • Pages: E364-E368
  • First Published: 10 October 2023
The FLT3N701K mutation causes clinical AML resistance to gilteritinib and triggers TKI sensitivity switch to quizartinib

Free Access

Frequency and characteristics of chemotherapy-associated thrombotic microangiopathy: Analysis from a large pharmacovigilance database

Nattawat Klomjit,  Richard Evans,  Thomas K. Le,  Sophia L. Wells,  Jessica Ortega,  Olivia Green-Lingren,  Marshall Mazepa,  Meghan E. Sise,  Kenar D. Jhaveri,  Shruti Gupta, 
  • Pages: E369-E372
  • First Published: 23 September 2023
Frequency and characteristics of chemotherapy-associated thrombotic microangiopathy: Analysis from a large pharmacovigilance database

We used the information component (IC), a disproportionate Bayesian analysis comparing the number of observed versus expected adverse drug reactions, to determine the potential association between anti-neoplastic agents and thrombotic microangiopathy (TMA). The IC025 indicates the lower end of 95% of IC, in which a value >0 suggests a disproportionality signal between the drug of interest and the adverse drug reaction. Carfilzomib had the highest IC025 for TMA among all studied chemotherapies followed by gemcitabine, mitomycin, bevacizumab, and bortezomib.

Free Access

Drug-induced thrombotic microangiopathy and thrombotic thrombocytopenic purpura: A systematic review, 2018–2023

Sayeed Khan,  James N. George,  Sanober Nusrat, 
  • Pages: E373-E375
  • First Published: 27 September 2023
Free Access

Successful cord blood transplantation for del7q myelodysplastic syndrome in Pearson marrow pancreas syndrome

Zacharia H. Belgacem,  Sonia M. Dubois,  Elad Jacoby,  Paul L. Martin,  Sumit B. Parikh,  Mark D. Fleming,  Suneet Agarwal, 
  • Pages: E376-E379
  • First Published: 21 September 2023
Free Access

CMSS1::FLT1 rearrangement leads to ligand-independent activation of FLT1 signaling in acute myeloid leukemia

Liying Zhang,  Xiaoshan Yang,  Xueping Ge,  Bingzong Li,  Hong Zhang,  Jun Li,  Lingfeng Liu,  Xiaojun Chen,  Wentao Hu,  Yu Sun,  Sheng Xiao, 
  • Pages: E380-E382
  • First Published: 04 October 2023
Free Access

Adverse effects of delta-9-tetrahydrocannabinol on sickle red blood cells

Aline Hatem,  Sofia Esperti,  Nicoletta Murciano,  Min Qiao,  Maria Giustina Rotordam,  Nadine Becker,  Elie Nader,  Felix Maurer,  Laurent Pérès,  Guillaume Bouyer,  Lars Kaestner,  Philippe Connes,  Stéphane Egée, 
  • Pages: E383-E386
  • First Published: 06 October 2023
Adverse effects of delta-9-tetrahydrocannabinol on sickle red blood cells

THC triggers a pronounced entry of Ca2+, which may be deleterious, into sickle cell red blood cells via activation of the TRPV2 channel.

Open Access

A matching-adjusted indirect comparison of acalabrutinib versus zanubrutinib in relapsed or refractory chronic lymphocytic leukemia

Adam S. Kittai,  Alan Skarbnik,  Miguel Miranda,  Alan S. M. Yong,  Jack Roos,  Robert Hettle,  Sarah Palazuelos-Munoz,  Vikram Shetty,  Paolo Ghia, 
  • Pages: E387-E390
  • First Published: 09 October 2023

Video Abstract

Free Access

Comparison of the prognostic predictive value of Molecular International Prognostic Scoring System and Revised International Prognostic Scoring System in patients undergoing allogeneic hematopoietic stem cell transplantation for myelodysplastic neoplasms

Tingting Yang,  Binqian Jiang,  Yi Luo,  Yanmin Zhao,  Guifang Ouyang,  Jian Yu,  Jianping Lan,  Ying Lu,  Xiaoyu Lai,  Baodong Ye,  Yi Chen,  Lizhen Liu,  Yang Xu,  Pengfei Shi,  Haowen Xiao,  Huixian Hu,  Qunyi Guo,  Huarui Fu,  Yishan Ye,  Xinyu Wang,  Jie Sun,  Weiyan Zheng,  Jingsong He,  Yi Zhao,  Wenjun Wu,  Zhen Cai,  Guoqing Wei,  He Huang,  Jimin Shi, 
  • Pages: E391-E394
  • First Published: 20 September 2023
Free Access

Clinical events in a long-term prospective neonatal cohort of children with sickle cell disease: Evidence for a high disease burden without systematic preventive intensification with hydroxyurea

Alizée Soulié,  Annie Kamdem,  Florent Neumann,  Isabelle Hau,  Fouad Madhi,  Céline Delestrain,  Mickaël Shum,  Adèle Carlier-Gonod,  Aline Malterre,  Harry Lezeau,  Bassem Khazem,  Ekaterina Belozertseva,  Eric Guémas,  Ralph Epaud,  Serge Pissard,  Cécile Arnaud,  Corinne Pondarré, 
  • Pages: E395-E398
  • First Published: 26 October 2023
Free Access

Trends in dedicated care for females with bleeding disorders within U.S. hemophilia treatment centers

Allison P. Wheeler,  Ming Y. Lim,  Patricia S. Huguelet,  Julie Jaffray,  Janice M. Staber,  Kerry Funkhouser,  Shannon L. Carpenter,  Angela C. Weyand, 
  • Pages: E399-E402
  • First Published: 06 October 2023
Trends in dedicated care for females with bleeding disorders within U.S. hemophilia treatment centers

Graphical representation of increasing percentage of female patients seen at HTCs, percentage of females by diagnosis, number of clinics in existence, and absolute number of female patients seen over a 10-year period (top left then clockwise).

Free Access

Deciphering clonal architecture and evolutionary dynamics of secondary acute myeloid leukemia and donor-derived myelodysplastic syndrome using single-cell multi-omics analysis

Meng-Ta Sung,  Lo-Ho Chen,  Ya-Wen Chiang,  Jie-Yang Jhuang,  Yu-Chen Chang,  Gon-Shen Caleb Chen,  Ken-Hong Lim, 
  • Pages: E403-E406
  • First Published: 04 October 2023
Free Access

Clonal hematopoiesis in unexplained cytopenias

Han-yang Wu,  Chao-yang Gu,  Shuang Liu,  Qiao-feng Dong,  Lin Dong,  Liang Wang,  Xin-ru Wang,  Si-yuan Cui,  Zhao Li,  Xin-guang Liu,  Dao-xin Ma,  Chun-yan Ji, 
  • Pages: E407-E410
  • First Published: 02 October 2023
Clonal hematopoiesis in unexplained cytopenias

Mutational landscape of 76 CCUS patients.