Acta Crystallographica Section F

Nucleotide-bound crystal structures of SARS-CoV-2 NSP13 capture a state immediately following ATP hydrolysis and reveal how crystal packing can affect structure-based drug design targeting NSP13.

This work presents the structure of apo Escherichia coli glucokinase (ecGLK) bound with sulfate, a phosphate mimic, and the structure of ecGLK in complex with both glucose and phosphate, implying a role for phosphate in regulating the glucokinase activity.

Sucrose phosphorylases catalyse a bi-bi reaction that interconverts sucrose and phosphate into glucose α-1-phosphate and fructose. Here, we present the first crystal structure of a sucrose phosphorylase from a marine organism.

This study presents the first fully resolved crystal structure of human fascin1, revealing its conformational plasticity and key interdomain interactions critical for actin bundling and cancer metastasis. These findings provide a structural foundation for the development of allosteric inhibitors and pave the way for time-resolved crystallographic studies to explore fascin1 dynamics in metastasis and drug targeting.

Four crystal structures of rsCherry, where `rs' means reversible switchable, degraded under aerobic conditions provide valuable insights into oxygen-induced degradation in red fluorescent proteins.