Journal of Comparative Neurology is a systems neuroscience journal with the ultimate goal of understanding neural circuits and connections that give rise to behavioral patterns and different neural states. We are the oldest continually published basic neuroscience journal, established in 1891.

Research published in JCN has an interdisciplinary scope and covers all species from invertebrates to humans.

Journal Metrics

  • 5.3CiteScore
  • 2.1Journal Impact Factor
  • 46%Acceptance rate
  • 27 days Submission to first decision
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RESEARCH ARTICLE
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Dopaminergic Neurons in the Zebrafish Subpallium Belong to the Extended Medial Amygdala

  •  5 August 2025

Graphical Abstract

Dopaminergic Neurons in the Zebrafish Subpallium Belong to the Extended Medial Amygdala Issue 8, 2025

We identify directly adjacent to the pallial–subpallial boundary a pax6a-negative dorsal Vdd2 portion of the zebrafish larval subpallium that develops into the extended medial amygdala (EMeA). Zebrafish subpallial dopaminergic neurons that locate to Vdd2 belong to the EMeA and form a heterogeneous group differentially expressing calbindin2a and cortistatin/sst7.

RESEARCH ARTICLE
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The Role of the Amygdala in Nonbreeding Aggression in Male Green Anole Lizards, Anolis carolinensis

  •  24 July 2025

Graphical Abstract

The Role of the Amygdala in Nonbreeding Aggression in Male Green Anole Lizards, Anolis carolinensis Issue 7, 2025

During the non-breeding season, male green anoles display aggression that is regulated by the amygdala. Lesioning the amygdala led to a decrease in aggression, which was not observed in animals where the amygdala was missed or in saline controls. Also, plasma testosterone levels did not influence aggression in these males.

RESEARCH ARTICLE
Open access

Spatial Distribution and Morphology of CaMKII‐Expressing Amacrine Cells in Marmoset, Macaque, and Human Retina

  •  24 July 2025

Graphical Abstract

Spatial Distribution and Morphology of CaMKII-Expressing Amacrine Cells in Marmoset, Macaque, and Human Retina Issue 7, 2025

The study shows that amacrine cells expressing the alpha subunit of calcium/calmodulin-dependent protein kinase II (CaMKII) make up subpopulations of conventional and displaced amacrine cells. They include ON but not OFF starburst amacrine cells and multiple types of wide-field presumed GABAergic amacrine cells.

RESEARCH ARTICLE
Open access

A Regional Ultrastructural Analysis of the Cellular and Synaptic Architecture of the Mouse Vestibular Periphery, With Reference to the Chinchilla

  •  23 July 2025

Graphical Abstract

A Regional Ultrastructural Analysis of the Cellular and Synaptic Architecture of the Mouse Vestibular Periphery, With Reference to the Chinchilla Issue 7, 2025

Synaptic innervation in mouse inner ear vestibular hair cells has been a topic of interest lately, with the revelation of the importance of non-quantal transmission in Type I hair cells. Transmission electron microscopy and the dissector sampling method were used to assess synaptic ribbon counts per hair cell. We showed that although central Type I hair cells contain fewer synaptic ribbons, their calyces also receive a significant input from Type II hair cells on their outer surface.

RESEARCH ARTICLE
Open access

Persistent Disruptions in Prefrontal Connectivity Despite Behavioral Rescue by Environmental Enrichment in a Mouse Model of Rett Syndrome

  •  17 July 2025

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Persistent Disruptions in Prefrontal Connectivity Despite Behavioral Rescue by Environmental Enrichment in a Mouse Model of Rett Syndrome Issue 7, 2025

This study reveals that the loss of MeCP2 in Rett syndrome model mice disrupts prefrontal connectivity. Although early environmental enrichment helps mitigate behavioral deficits and restores hippocampal BDNF levels, it fails to reverse the altered prefrontal connectivity or prevent the prefrontal-specific decline in BDNF.

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The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

  •  3865-3895
  •  17 May 2016

Graphical Abstract

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting Issue 18, 2016

The number of glial cells in human brains has been vastly overestimated. The real number of glia is in fact lower than the number of neurons. The origin, perpetuation, and the debunking of the claim of one trillion glial cells in human brains are the topics of this review.

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