PROTEINS: Structure, Function, and Bioinformatics is an international protein science journal publishing experimental and analytic research in all areas of the field, encompassing protein structure, function, computation, genetics, and design.

We encourage reports that present new experimental or computational approaches for interpreting and understanding data. PROTEINS : Structure, Function, and Bioinformatics is read globally by researchers in a variety of fields – from biochemists to crystallographers.

Journal Metrics

  • 7.2CiteScore
  • 2.8Journal Impact Factor
  • 25%Acceptance rate
  • 8 days Submission to first decision
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About This Journal

PROTEINS : Structure, Function, and Bioinformatics publishes original reports of significant experimental and analytic research in all areas of protein research: structure, function, computation, genetics, and design.

The journal encourages reports that present new experimental or computational approaches for interpreting and understanding data from:

  • Biophysical chemistry
  • Structural studies of proteins and macromolecular assemblies
  • Alterations of protein structure and function engineered through techniques of molecular biology 
  • Genetics
  • Functional analyses under physiologic conditions
  • Interactions of proteins with receptors, nucleic acids, or other specific ligands or substrates

Read the full Aims and Scope here.

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Articles

RESEARCH ARTICLE
Open access

The SIRT1 N-Terminal Domain as a Common Binding Interface for PPARγ Anchoring

Caique Camargo Malospirito, Gabriel Ernesto Jara, Víctor Ulian Antunes, Giovanna Blazutti Elias, Marieli Mariano Goncalves Dias, Fernanda Aparecida Heleno Batista, Paulo Sergio Lopes de Oliveira, Ana Carolina Migliorini Figueira, 
  •  17 July 2025
RESEARCH ARTICLE
Open access

Biomolecular Interaction Prediction in the Pre- and Post-AlphaFold Era: The 8th CAPRI Evaluation

Marc F. Lensink, Nessim Raouraoua, Guillaume Brysbaert, Sameer Velankar, Shoshana J. Wodak, Alexandre M. J. J. Bonvin, 
  •  14 July 2025
RESEARCH ARTICLE
Open access

Supervised Learning of Protein Melting Temperature: Cross‐Species vs. Species‐Specific Prediction

Sebastián García López, Jesper Salomon, Wouter Boomsma, 
  •  14 July 2025
RESEARCH ARTICLE

Structural Mimicry Without Glyoxalase I Functional Convergence: A Homogentisate 1,2-Dioxygenase From Acinetobacter

Pil-Won Seo, Seung-A Hwangbo, Jeong-Sun Kim, Suk-Youl Park, 
  •  12 July 2025
RESEARCH ARTICLE

Predicting the Oligomeric State of Proteins Using Multiple Templates Detected by Complementary Alignment Methods

Yuxian Luo, Haiyan Wu, Hong Wei, Zhenling Peng, Jianyi Yang, 
  •  10 July 2025
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