Mary Chesshyre, Deborah Ridout, Georgia Stimpson, Valeria Ricotti, Silvana De Lucia, Erik H Niks, Volker Straub, Laurent Servais, Jean-Yves Hogrel, Giovanni Baranello, Adnan Manzur, UK NorthStar Clinical Network and Francesco Muntoni* on behalf of the iMDEX network.
Males with Duchenne muscular dystrophy aged 5 years to 18 years were subdivided according to the predicted effects of the participants' DMD mutation on dystrophin isoform expression (group 1, Dp427 absent, Dp140/Dp71 present; group 2, Dp427/Dp140 absent, Dp71 present).
Predicted reduced Dp140 expression was associated with reduced grip and pinch strength.
Predicted reduced Dp140 expression was associated with reduced forced vital capacity percent predicted.
Left: Distribution of NIH funding, as percentages, for different categories within the CP portfolio. Right: NIH allocation, in dollars, for stroke, autism spectrum disorders, Parkinson#x00027;s disease, multiple sclerosis, and cerebral palsy.
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