Pediatric Transplantation

Findings suggest that ChatGPT could be a useful tool for adolescents or caregivers to cover general aspects of kidney transplantation. While the overall scores of accuracy and relevancy are impressive, the presence of potentially risky outputs underscores the necessity for human oversight and validation.

Tacrolimus clearance (CL/F) varies with hemoglobin and cholesterol levels in pediatric kidney transplant recipients, as shown in this retrospective study. Lower hemoglobin increases CL/F, while higher cholesterol reduces it, underscoring the potential for biochemical parameters to enhance therapeutic drug monitoring and dosing strategies.

Survival after allogeneic hematopoietic stem cell transplants (aHSCTs) in the state of Florida since the creation of a state pediatric HSCT consortium has improved. This is significant because it demonstrates that small-sized pediatric HSCT centers can work together in a consortium to improve outcomes similar to larger centers.

Routine pretransplant PGx testing provides frequently actionable data to optimize posttransplant medication regimens, potentially avoiding adverse effects of medications including tacrolimus, azathioprine, HMG-CoA reductase inhibitors, and dapsone, while also providing important information related to thrombosis risk for VTE prophylaxis.

ARD is prevalent among ESKD children. Younger age, lower BMI Z-scores, HTN, and increased Ca × Ph are risk factors for ARD. ARD frequency decreases on ≥ 6-month follow-up of patients.

This study describes the incidence and clinical characteristics of Cytomegalovirus (CMV) reactivation in children undergoing hematopoietic stem cell transplantation (HSCT) in Colombia. Among 166 pediatric recipients, CMV viremia occurred in 28% of patients within 100 days post-transplant, with no significant differences in reactivation rates or treatment outcomes based on donor type. One-year overall survival was 60%, and CMV reactivation did not negatively impact survival outcomes. The findings highlight the need for further research to refine monitoring strategies, particularly in regions using unmanipulated stem cells with PTCy.

In a study of 42 patients with VOD, 50% were diagnosed with TA-TMA (5 clinically, 16 retrospectively). Survival rates at 1 year were 66.7% for VOD only, 60% for VOD+TA-TMA, and 62.5% for VOD+rTA-TMA (p = 0.9582). Understanding these endotheliopathies is vital for improving diagnosis, treatment, and patient outcomes.

Limited health literacy is common in pediatric kidney transplant recipients and families and is associated with increased frequency of hospital and outpatient clinic department visits early post-transplant.

Intestinal complications (IC) are significant adverse events following liver transplantation (LT), yet research on pediatric cohorts remains limited. This study aims to describe IC in children after LT and identify factors associated with their occurrence. Recognizing these factors may help medical teams diagnose IC earlier in pediatric LT patients, leading to improved outcomes.

Liver transplantation in the treatment of HoFH partially helped our patients to reach the target LDL-cholesterol level after transplantation and did not prevent the development of cardiovascular disease.

In this single-center study of 177 pediatric heart transplant recipients, 7% developed acute kidney injury requiring dialysis (AKI-D), with increased cardiopulmonary bypass time and higher weight at transplant associated with higher odds of AKI-D. AKI-D was associated with greater mortality during initial hospitalization and lower kidney failure-free survival.