Inflammation initiated by endogenous or exogenous stimuli regulates bone tissue formation and resorption. Mechanisms of activity of inflammatory mediators appear to be important players in skeletal health, metabolic disorders, and ageing. The crosstalk between immune cells (e.g. osteoclasts) and cells closely related to skeletal renewal (mesenchymal stem cells, osteogenic, chondrogenic, and adipogenic lineages, and endothelial cells) is essential for bone homeostasis and forms the fundamental basis of osteoimmunology.

In addition to bone physiology, this Special Issue aims to collect findings emphasizing the role of inflammatory cues (at the cellular and molecular levels) in disease and bone loss-associated states, as well as marrow adiposity expansion, neoplasm development and bone grafting.

For this Special Issue, authors are encouraged to submit their original research or review articles that describe important novel results and highlight the current state in osteoimmunology, addressing significant topics for the maintenance and improvement of skeletal system health.

Potential topics include but are not limited to the following:

• Crosstalk between bone marrow skeletal cells, hematopoietic stem cells, and immunity in skeletal system formation, maturation, homeostasis, regeneration, and remodelling
• Osteoporosis and osteoarthritis - inflammatory bone diseases
• Inflammatory mediators as regulators of bone metabolism and mineralization
• Neuroendocrine control of bone tissue during inflammation
• Bone marrow adipose tissue physiology and regulation of inflammatory condition in metabolic bone diseases
• Roles of complement and coagulation system in bone injuries and healing
• Bone fractures and inflammation in metabolic bone diseases
• Bone-associated neoplastic growth: myeloid and lymphoid lineages transformation and bone as metastatic niche
• Bone-implant interface: bone grafts immunobiology