The evolution of tissue engineering research gives an opportunity to improve functional and cosmetic outcomes in the field of otolaryngology. Currently, regeneration studies using tissue engineering applications with or without stem cells in the ear and throat areas are mainly translational using animal model experiments. There are still few reports on clinical application in patients. Tissue engineering (TE) holds the potential to address barriers through the provision of new, healthy tissue identical to the host.

Regenerative medicine in otolaryngology is important to improve patient’s quality of life. Translational and convergent research is vital. Through multidisciplinary efforts and collaboration, functional and cosmetic properties of the ear, nose, airway, and craniofacial bone will be advanced when tissue-engineered constructs become available for routine clinical use.

This Special Issue aims to collate original research and review articles describing the recent advances in this field.

Potential topics include but are not limited to the following:

• Auricle regeneration
• Hearing regeneration
• Mastoid obliteration
• Facial nerve regeneration
• Facial bone regeneration
• Trachea regeneration