An update on the impact of COVID-19 on haematology practice from selected papers published in BJHaem in 2022.

Virtual Issues
10 March 2022
24 March 2022
This collection focuses on the efficacy and side effects of vaccines in particular disease groups. New insights into viral pathophysiology and thrombotic complications are highlighted.
Export Citation(s)Download PDF(s)

Pathophysiology

RESEARCH PAPER

Platelets modulate CD4+ T-cell function in COVID-19 through a PD-L1 dependent mechanism

Ana Paletta,  Facundo Di Diego García,  Augusto Varese,  Fernando Erra Diaz,  Julián García,  Juan Carlos Cisneros,  Guillermina Ludueña,  Ignacio Mazzitelli,  Andrea Pisarevsky,  Gonzalo Cabrerizo,  Álvaro López Malizia,  Alejandra G. Rodriguez,  Nicolás Lista,  Yesica Longueira,  Juan Sabatté,  Jorge Geffner,  Federico Remes Lenicov,  Ana Ceballos, 
Commentary
Free Access

Resolving sticky relationships between platelets and lymphocytes in COVID-19: A role for checkpoint inhibitors?

Parizad Torabi-Parizi,  Anthony F. Suffredini, 
Correspondence
Free Access

Divergent impacts of tocilizumab and colchicine in COVID-19-associated coagulopathy: the role of alpha-defensins

Suhair Abdeen,  Rami Abu-Fanne,  Khalil Bdeir,  Emad Maraga,  Mohamed Higazi,  Douglas B. Cines,  Samuel N. Heyman,  Abd Al-Roof Higazi, 
RESEARCH PAPER

Plasma microparticles of intubated COVID-19 patients cause endothelial cell death, neutrophil adhesion and netosis, in a phosphatidylserine-dependent manner

Yohann Garnier,  Livia Claude,  Patricia Hermand,  Evely Sachou,  Aurélie Claes,  Kassandra Desplan,  Bassel Chahim,  Pierre-Marie Roger,  Frédéric Martino,  Yves Colin,  Caroline Le Van Kim,  Véronique Baccini,  Marc Romana, 
Correspondence
Free Access

Activation of circulating platelets in vaccine-induced thrombotic thrombocytopenia and its reversal by intravenous immunoglobulin

James D. McFadyen,  Prerna Sharma,  Mitchell J. Moon,  Jonathan Noonan,  Elizabeth Goodall,  Huyen A. Tran,  Karlheinz Peter, 
Correspondence
Free Access

Association of Rhesus factor blood type with risk of SARS-CoV-2 infection and COVID-19 severity

Jeffrey L. Anderson,  Heidi T. May,  Stacey Knight,  Tami L. Bair,  Benjamin D. Horne,  Kirk U. Knowlton, 

Disease-specific effects of COVID-19, vaccines, and immune competence

Short Report

Efficacy and safety of heterologous booster vaccination with Ad26.COV2.S after BNT162b2 mRNA COVID-19 vaccine in haemato-oncological patients with no antibody response

Patrick Reimann,  Hanno Ulmer,  Beatrix Mutschlechner,  Magdalena Benda,  Luciano Severgnini,  Andreas Volgger,  Theresia Lang,  Michele Atzl,  Minh Huynh,  Klaus Gasser,  Claudia Grabher,  Sylvia Mink,  Peter Fraunberger,  Ulf Petrausch,  Bernd Hartmann,  Thomas Winder, 
Research Paper
Open Access

Key findings from the UKCCMP cohort of 877 patients with haematological malignancy and COVID-19: disease control as an important factor relative to recent chemotherapy or anti-CD20 therapy

Stephen Booth,  Helen M. Curley,  Csilla Varnai,  Roland Arnold,  Lennard Y. W. Lee,  Naomi A. Campton,  Gordon Cook,  Karin Purshouse,  James Aries,  Andrew Innes,  Lucy B. Cook,  Oliver Tomkins,  Helen S. Oram,  Michael Tilby,  Austin Kulasekararaj,  David Wrench,  Saoirse Dolly,  Tom Newsom-Davies,  Ruth Pettengell,  Abigail Gault,  Sam Moody,  Sajjan Mittal,  Mohammed Altohami,  Tania Tillet,  Jack Illingworth,  Leena Mukherjee,  Jane Apperly,  John Ashcroft,  Neil Rabin,  Jonathan Carmichael,  Jean-Baptiste Cazier,  Rachel Kerr,  Gary Middleton,  Graham P. Collins,  Claire Palles,  UKCCMP team , 
SHORT REPORT

Third dose of COVID-19 vaccine restores immune response in patients with haematological malignancies after loss of protective antibody titres

Ondrej Šušol,  Barbora Hájková,  Hana Zelená,  Roman Hájek, 

Plasma Cell Dyscrasia

SHORT REPORT

Depletion of CD38-positive regulatory T cells by anti-CD38 monoclonal antibodies induces a durable response to SARS-CoV-2 vaccination in patients with plasma cell dyscrasia

Toshiki Terao,  Takashi Naduka,  Daisuke Ikeda,  Ami Fukumoto,  Yuya Kamura,  Ayumi Kuzume,  Rikako Tabata,  Takafumi Tsushima,  Daisuke Miura,  Kentaro Narita,  Masami Takeuchi,  Kosei Matsue, 
COMMENTARY
Free Access

Serological response to SARS-CoV-2 mRNA-containing lipid nanoparticle vaccine in patients with multiple myeloma: A negative impact of CD38+ regulatory T cells?

Frédéric Baron,  Jo Caers,  Stéphanie Humblet-Baron, 
RESEARCH PAPER
Open Access

Immune response to COVID-19 vaccination is attenuated by poor disease control and antimyeloma therapy with vaccine driven divergent T-cell response

Karthik Ramasamy,  Ross Sadler,  Sally Jeans,  Paul Weeden,  Sherin Varghese,  Alison Turner,  Jemma Larham,  Nathanael Gray,  Oluremi Carty,  Joe Barrett,  Stella Bowcock,  Udo Oppermann,  Gordon Cook,  Chara Kyriakou,  Mark Drayson,  Supratik Basu,  Sally Moore,  Sarah McDonald,  Sarah Gooding,  Muhammad K. Javaid, 
Short Report

Myeloma patients with COVID-19 have superior antibody responses compared to patients fully vaccinated with the BNT162b2 vaccine

Maria Gavriatopoulou,  Evangelos Terpos,  Panagiotis Malandrakis,  Ioannis Ntanasis-Stathopoulos,  Alexandros Briasoulis,  Sentiljana Gumeni,  Despina Fotiou,  Eleni-Dimitra Papanagnou,  Magdalini Migkou,  Foteini Theodorakakou,  Evangelos Eleutherakis-Papaiakovou,  Nikolaos Kanellias,  Ioannis P. Trougakos,  Efstathios Kastritis,  Meletios-Athanasios Dimopoulos, 

Lymphoid Malignancies

COMMENTARY
Free Access

COVID-19 vaccine response in chronic lymphocytic leukaemia is more than just seroconversion

Clare Sun, 
RESEARCH PAPER
Open Access

Rituximab-treated patients with lymphoma develop strong CD8 T-cell responses following COVID-19 vaccination

Jon Riise,  Saskia Meyer,  Isaac Blaas,  Adity Chopra,  Trung T. Tran,  Marina Delic-Sarac,  Malu Lian Hestdalen,  Ellen Brodin,  Even Holth Rustad,  Ke-Zheng Dai,  John Torgils Vaage,  Lise Sofie Haug Nissen-Meyer,  Fredrik Sund,  Karin F. Wader,  Anne T. Bjornevik,  Peter A. Meyer,  Gro O. Nygaard,  Marton König,  Sigbjørn Smeland,  Fridtjof Lund-Johansen,  Johanna Olweus,  Arne Kolstad, 
Research Paper
Open Access

T-cell immune response after mRNA SARS-CoV-2 vaccines is frequently detected also in the absence of seroconversion in patients with lymphoid malignancies

Vincenzo Marasco,  Cristiana Carniti,  Anna Guidetti,  Lucia Farina,  Martina Magni,  Rosalba Miceli,  Ludovica Calabretta,  Paolo Verderio,  Silva Ljevar,  Fabio Serpenti,  Daniele Morelli,  Giovanni Apolone,  Giuseppe Ippolito,  Chiara Agrati,  Paolo Corradini, 

Myeloid Malignancies

Research Paper

COVID-19 infection in chronic myeloid leukaemia after one year of the pandemic in Italy. A Campus CML report

Massimo Breccia,  Elisabetta Abruzzese,  Vincenzo Accurso,  Immacolata Attolico,  Sara Barulli,  Micaela Bergamaschi,  Gianni Binotto,  Monica Bocchia,  Massimiliano Bonifacio,  Giovanni Caocci,  Isabella Capodanno,  Fausto Castagnetti,  Francesco Cavazzini,  Elena Crisà,  Monica Crugnola,  Maria Stella De Candia,  Chiara Elena,  Carmen Fava,  Sara Galimberti,  Antonella Gozzini,  Gabriele Gugliotta,  Tamara Intermesoli,  Alessandra Iurlo,  Gaetano La Barba,  Roberto Latagliata,  Sabrina Leonetti Crescenzi,  Luciano Levato,  Giuseppina Loglisci,  Alessandro Lucchesi,  Luigiana Luciano,  Francesca Lunghi,  Debora Luzi,  Alessandra Malato,  Maria Cristina Miggiano,  Michele Pizzuti,  Patrizia Pregno,  Davide Rapezzi,  Giovanna Rege-Cambrin,  Gianantonio Rosti,  Sabina Russo,  Rosaria Sancetta,  Anna Rita Scortechini,  Federica Sorà,  Paolo Sportoletti,  Fabio Stagno,  Agostino Tafuri,  Mario Tiribelli,  Robin Foà,  Giuseppe Saglio, 
ORIGINAL PAPER
Open Access

Humoral response to mRNA-based COVID-19 vaccine in patients with myeloid malignancies

Akio Mori,  Masahiro Onozawa,  Shihori Tsukamoto,  Takashi Ishio,  Emi Yokoyama,  Koh Izumiyama,  Makoto Saito,  Haruna Muraki,  Masanobu Morioka,  Takanori Teshima,  Takeshi Kondo, 

Stem Cell Transplantation

Research Paper

Immunogenicity and safety of the BNT162b2 mRNA COVID-19 vaccine in haematopoietic stem cell transplantation recipients

Noga Shem-Tov,  Ronit Yerushalmi,  Ivetta Danylesko,  Vladislav Litachevsky,  Itzchak Levy,  Liraz Olmer,  Yaniv Lusitg,  Abraham Avigdor,  Arnon Nagler,  Avichai Shimoni,  Galia Rahav, 
Commentary
Free Access

Effectiveness of COVID-19 vaccination in patients after allogeneic haematopoietic cell transplant: how much protection are we getting?

Salyka Sengsayadeth,  Larisa Broglie,  Bipin N. Savani,