Dual-Modal Optical Imaging of Tissue Perfusion in Response to Cooling Stimulation Facilitates Early Detection of Pressure Ulcer
Qingdong Zhang
Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China
Search for more papers by this authorCorresponding Author
Peng Liu
University of Science and Technology of China, Hefei, China
Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, China
Correspondence:
Peng Liu ([email protected])
Ronald X. Xu ([email protected])
Search for more papers by this authorPengfei Shao
Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China
Search for more papers by this authorMingzhai Sun
University of Science and Technology of China, Hefei, China
Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, China
Search for more papers by this authorPeng Yao
Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China
Search for more papers by this authorShuwei Shen
University of Science and Technology of China, Hefei, China
Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, China
Search for more papers by this authorYang Zhang
Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China
Search for more papers by this authorMing Wu
Department of Rehabilitation, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
Search for more papers by this authorCorresponding Author
Ronald X. Xu
Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China
University of Science and Technology of China, Hefei, China
Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, China
Correspondence:
Peng Liu ([email protected])
Ronald X. Xu ([email protected])
Search for more papers by this authorQingdong Zhang
Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China
Search for more papers by this authorCorresponding Author
Peng Liu
University of Science and Technology of China, Hefei, China
Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, China
Correspondence:
Peng Liu ([email protected])
Ronald X. Xu ([email protected])
Search for more papers by this authorPengfei Shao
Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China
Search for more papers by this authorMingzhai Sun
University of Science and Technology of China, Hefei, China
Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, China
Search for more papers by this authorPeng Yao
Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China
Search for more papers by this authorShuwei Shen
University of Science and Technology of China, Hefei, China
Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, China
Search for more papers by this authorYang Zhang
Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China
Search for more papers by this authorMing Wu
Department of Rehabilitation, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
Search for more papers by this authorCorresponding Author
Ronald X. Xu
Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei, China
University of Science and Technology of China, Hefei, China
Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, China
Correspondence:
Peng Liu ([email protected])
Ronald X. Xu ([email protected])
Search for more papers by this authorFunding: This research was supported by the National Key R&D Program of China (Grant Nos. 2021YFC2401402 and 2022YFA1104800) and the Natural Science Foundation of Jiangsu Province (Grant No. BK20231213).
ABSTRACT
Pressure ulcers present a significant human and economic challenge, lacking a reliable method for early detection. To address this, we developed a system capable of early detection by using cooling stimulation and dynamic data acquisition techniques to monitor blood perfusion and skin temperature. The system consists of laser speckle perfusion imaging and thermal imaging. And we performed simulations to demonstrate that the system is capable of detect tissue damage across multiple layers, from superficial to deep. Testing on a rabbit ear model demonstrated that this approach, which combines dynamic perfusion and temperature parameters, effectively distinguishes early pressure ulcer areas from normal skin with a significant p value of 0.0015. This distinction was more precise compared to methods relying solely on static parameters or one parameter. Our study thereby offers a promising advancement in the proactive management and prevention of pressure ulcers.
Conflicts of Interest
The authors declare no conflicts of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Supporting Information
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| jbio202400188-sup-0001-Supinfo.docxWord 2007 document , 60.1 KB |
Data S1. Supporting Information. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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