Toward Rational Design of Carbon Nanodots with High Photothermal Efficiency for Tumor Photothermal Therapy†
Enshan Liu
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau SAR, 999078 China
These authors contributed equally to this work.
Search for more papers by this authorJun Wu
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau SAR, 999078 China
These authors contributed equally to this work.
Search for more papers by this authorTao Liang
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau SAR, 999078 China
Search for more papers by this authorBohan Zhang
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau SAR, 999078 China
Search for more papers by this authorCorresponding Author
Zikang Tang
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau SAR, 999078 China
Department of Physics and Chemistry, Faculty of Science and Technology, University of Macau, Macao SAR, 999078 China
MOE Frontier Science Centre for Precision Oncology, University of Macau, Macao SAR, 999078 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Songnan Qu
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau SAR, 999078 China
Department of Physics and Chemistry, Faculty of Science and Technology, University of Macau, Macao SAR, 999078 China
MOE Frontier Science Centre for Precision Oncology, University of Macau, Macao SAR, 999078 China
E-mail: [email protected]; [email protected]Search for more papers by this authorEnshan Liu
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau SAR, 999078 China
These authors contributed equally to this work.
Search for more papers by this authorJun Wu
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau SAR, 999078 China
These authors contributed equally to this work.
Search for more papers by this authorTao Liang
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau SAR, 999078 China
Search for more papers by this authorBohan Zhang
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau SAR, 999078 China
Search for more papers by this authorCorresponding Author
Zikang Tang
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau SAR, 999078 China
Department of Physics and Chemistry, Faculty of Science and Technology, University of Macau, Macao SAR, 999078 China
MOE Frontier Science Centre for Precision Oncology, University of Macau, Macao SAR, 999078 China
E-mail: [email protected]; [email protected]Search for more papers by this authorCorresponding Author
Songnan Qu
Joint Key Laboratory of the Ministry of Education, Institute of Applied Physics and Materials Engineering, University of Macau, Taipa, Macau SAR, 999078 China
Department of Physics and Chemistry, Faculty of Science and Technology, University of Macau, Macao SAR, 999078 China
MOE Frontier Science Centre for Precision Oncology, University of Macau, Macao SAR, 999078 China
E-mail: [email protected]; [email protected]Search for more papers by this authorDedicated to the Special Issue of Carbon Dots Based Functional Materials.
Comprehensive Summary
Carbon nanodots (CDs) with high photothermal performance are ideal candidates for tumor photothermal therapy (PTT). Herein, we investigated the photothermal performance of CDs synthesized from urea and citric acid via solvothermal method in dimethyl sulfoxide (DMSO) at different temperatures. Photothermal conversion efficiency (PCE) of up to 61.3% was obtained in the CDs synthesized at 150 °C (150-CDs), which is much better than the CDs synthesized at 180 °C (180-CDs). By analyzing the morphologies, chemical structures, and absorption spectra of these CDs, we found that the photothermal effect of the CDs was due to the lattice vibration of their carbonized cores, in which moderate carbonization with high content of surface carbonyl group (C=O) contributed for enhanced absorption band in deep red region with improved photothermal performance. Moreover, we also demonstrated that 150-CDs with moderate carbonized cores exhibit much better tumor PTT performance in vivo than 180-CDs with higher carbonized cores.
Supporting Information
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Appendix S1: Supporting Information |
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Citing Literature
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