Polydimethylsiloxane: A General Matrix for High-Performance Chromatographic NMR Spectroscopy†
Corresponding Author
Dr. Shaohua Huang
Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101 (China)
Shaohua Huang, Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101 (China)
Zhengwu Bai, School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073 (China)
Search for more papers by this authorDr. Jun Gao
Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101 (China)
Search for more papers by this authorRui Wu
School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073 (China)
Search for more papers by this authorProf. Dr. Shengying Li
Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101 (China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Zhengwu Bai
School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073 (China)
Shaohua Huang, Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101 (China)
Zhengwu Bai, School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073 (China)
Search for more papers by this authorCorresponding Author
Dr. Shaohua Huang
Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101 (China)
Shaohua Huang, Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101 (China)
Zhengwu Bai, School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073 (China)
Search for more papers by this authorDr. Jun Gao
Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101 (China)
Search for more papers by this authorRui Wu
School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073 (China)
Search for more papers by this authorProf. Dr. Shengying Li
Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101 (China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Zhengwu Bai
School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073 (China)
Shaohua Huang, Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101 (China)
Zhengwu Bai, School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073 (China)
Search for more papers by this authorThis research was supported by the National Natural Science Foundation of China (grant number 21105108). We thank Dr. Lishan Yao and Dr. Sifu Tang (Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences) for helpful discussions.
Abstract
The detection and structural characterization of the components of a mixture is a challenging task. Therefore, the development of a facile and general method that enables both the separation and the structural characterization of the components is desired. Diffusion-ordered NMR spectroscopy (DOSY) with the aid of a matrix is a promising tool for this purpose. However, because the currently existing matrices only separate limited components, the application of the DOSY technique is restricted. Herein we introduce a new versatile matrix, poly(dimethylsiloxane), which can fully separate many mixtures of different structural types by liquid-state NMR spectroscopy. With poly(dimethylsiloxane), liquid-state chromatographic NMR spectroscopy could become a general approach for the structural elucidation of mixtures of compounds.
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