Bionic design of the oral swallowing in vitro and its application in the dysphagia
Corresponding Author
Shanhua Qian
School of Mechanical Engineering, Jiangnan University, Wuxi, Jiangsu, China
Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment and Technology, Jiangnan University, Wuxi, Jiangsu, China
Correspondence
Shanhua Qian, School of Mechanical Engineering, Jiangnan University, No. 1800 Lihu Avenue, Wuxi 214122, Jiangsu, China.
Email: [email protected]
Contribution: Conceptualization (equal), Formal analysis (equal), Funding acquisition (lead), Investigation (lead), Methodology (equal), Project administration (lead), Resources (equal), Validation (lead), Writing - review & editing (lead)
Search for more papers by this authorYue Wu
School of Mechanical Engineering, Jiangnan University, Wuxi, Jiangsu, China
Contribution: Conceptualization (equal), Data curation (equal), Investigation (equal), Methodology (lead), Software (lead), Writing - original draft (equal)
Search for more papers by this authorZhiyong Wang
Department of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fugian, China
Contribution: Data curation (equal), Investigation (supporting), Resources (equal), Validation (equal)
Search for more papers by this authorCheng Zhang
School of Mechanical Engineering, Jiangnan University, Wuxi, Jiangsu, China
Contribution: Data curation (supporting), Investigation (equal), Validation (equal), Writing - review & editing (lead)
Search for more papers by this authorJianfeng Huang
Department of Radiation Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China
Contribution: Data curation (equal), Investigation (supporting), Software (equal), Visualization (supporting)
Search for more papers by this authorJinghu Yu
School of Mechanical Engineering, Jiangnan University, Wuxi, Jiangsu, China
Search for more papers by this authorCorresponding Author
Shanhua Qian
School of Mechanical Engineering, Jiangnan University, Wuxi, Jiangsu, China
Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment and Technology, Jiangnan University, Wuxi, Jiangsu, China
Correspondence
Shanhua Qian, School of Mechanical Engineering, Jiangnan University, No. 1800 Lihu Avenue, Wuxi 214122, Jiangsu, China.
Email: [email protected]
Contribution: Conceptualization (equal), Formal analysis (equal), Funding acquisition (lead), Investigation (lead), Methodology (equal), Project administration (lead), Resources (equal), Validation (lead), Writing - review & editing (lead)
Search for more papers by this authorYue Wu
School of Mechanical Engineering, Jiangnan University, Wuxi, Jiangsu, China
Contribution: Conceptualization (equal), Data curation (equal), Investigation (equal), Methodology (lead), Software (lead), Writing - original draft (equal)
Search for more papers by this authorZhiyong Wang
Department of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fugian, China
Contribution: Data curation (equal), Investigation (supporting), Resources (equal), Validation (equal)
Search for more papers by this authorCheng Zhang
School of Mechanical Engineering, Jiangnan University, Wuxi, Jiangsu, China
Contribution: Data curation (supporting), Investigation (equal), Validation (equal), Writing - review & editing (lead)
Search for more papers by this authorJianfeng Huang
Department of Radiation Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China
Contribution: Data curation (equal), Investigation (supporting), Software (equal), Visualization (supporting)
Search for more papers by this authorJinghu Yu
School of Mechanical Engineering, Jiangnan University, Wuxi, Jiangsu, China
Search for more papers by this authorThis article was published on AA publication on: 13 June 2022.
Funding information: Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment and Technology (Jiangnan University), Grant/Award Number: FMZ201907; Jiangnan University; China Postdoctoral Science Foundation, Grant/Award Number: 2018T110439; National Natural Science Foundation of China, Grant/Award Number: 51775244
Abstract
Dysphagia, the swallowing disorder, is a common disease among the elders and stroke patients. Therefore, based on the bionic swallowing device (BSD) in vitro of similar human-tongue motion during swallowing, the development of functional food is necessary to improve the food swallowing quality of the deglutition disorders patients. In this study, the tongue motion was thoroughly investigated by extracting the characteristic data, and appropriate mechanisms in vitro were adopted to replicate the motion of the tongue swallowing according to the normal swallowing oropharyngeal data. The application of the BSD was also investigated at different swallowing grades (SGs). The study results indicated that the tongue motion consisted of tongue root point (TRP) and several tongue motor points (TMPs). The cam-link and push-rod mechanisms showed ellipse lines for TRP motion and straight lines for TMPs, respectively. Higher correlation coefficients between the tongue trajectories in the oropharyngeal data and simulated curves of the combined mechanism were observed. The average correlation coefficients between the tongue trajectories of patients at five SGs and those of the BSD were 0.87, proving its effectiveness and potential application. Furthermore, the corn-paste experiments of the BSD showed that dysphagia at five SGs could be a suitable choice for certain food concentrations. This will provide valuable insight into developing more functional foods in vitro for high deglutition disorders.
Open Research
DATA AVAILABILITY STATEMENT
The data that support the findings of this study are available from the corresponding author upon reasonable request.
REFERENCES
- Bonilha, H. S., Blair, J., Carnes, B., Huda, W., Humphries, K., McGrattan, K., … Martin-Harris, B. (2013). Preliminary investigation of the effect of pulse rate on judgments of swallowing impairment and treatment recommendations. Dysphagia, 28, 528–538. https://doi.org/10.1007/s00455-013-9463-z
- Chen, W. Y., Byrd, D., Narayanan, S., & Nayak, K. S. (2019). Intermittently tagged real-time MRI reveals internal tongue motion during speech production. Magnetic Resonance in Medicine, 82(5), 600–613. https://doi.org/10.1002/mrm.27745
- Cichero, J. A. Y., Lam, P., Steele, C. M., Hanson, B., Chen, J., Dantas, R. O., … Stanschus, S. (2017). Development of international terminology and definitions for texture-modified foods and thickened fluids used in dysphagia management: The IDDSI framework. Dysphagia, 32(2), 293–314. https://doi.org/10.1007/s00455-016-9758-y
- Colin, C., & Ivan, G. (2016). Water drinking test: New applications. Clinical and Experimental Ophthalmology, 44(2), 87–88. https://doi.org/10.1111/ceo.12718
- Counter, P. R., & Ong, J. H. (2018). Disorders of swallowing. Surgery (Oxford), 36(10), 535–542. https://doi.org/10.1016/j.mpsur.2018.08.004
10.1016/j.mpsur.2018.08.004 Google Scholar
- Ekberg, O., Hamdy, S., Woisard, V., Wuttge-Hannig, A., & Ortega, P. (2002). Social and psychological burden of dysphagia: Its impact on diagnosis and treatment. Dysphagia, 17(2), 139–146. https://doi.org/10.1007/s00455-001-0113-5
- Fan, Y. X., Liang, Y., & Zhang, L. (2014). Mechanical principle and mechanical design. China: Beijing.
- Farrar, E., Balasubramanian, A., & Eubanks, J. C. (2014). Real-time motion capture of the human tongue. Acm Siggraph 2014 Talks, 19(1), 1–13. https://doi.org/10.1145/2614106.2614176
10.1145/2614106.2614176 Google Scholar
- Hirota, N., Konaka, K., Ono, T., Tamine, K., Kondo, J., Hori, K., … Naritomi, H. (2010). Reduced tongue pressure against the hard palate on the paralyzed side during swallowing predicts dysphagia in patients with acute stroke. Stroke; a Journal of Cerebral Circulation, 41(12), 2982–2984. https://doi.org/10.1161/Strokeaha.110.594960
- Ho, A. K., Tsou, L., Green, S., & Fels, S. (2014). A 3D swallowing simulation using smoothed particle hydrodynamics. Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 2(4), 237–244. https://doi.org/10.1080/21681163.2013.862862
10.1080/21681163.2013.862862 Google Scholar
- Ichiro, F. (1999). Eating and swallowing disorders in stroke. Tokyo: Medical Dental Publishing co., Ltd.
- Ishihara, S., Nakao, S., Nakauma, M., Funami, T., Hori, K., Ono, T., … Nishinari, K. (2013). Compression test of food gels on artificial tongue and its comparison with human test. Journal of Texture Studies, 44, 104–114. https://doi.org/10.1111/jtxs.12002
- Jack, F. R., & Gibbon, F. (1995). Electropalatography in the study of tongue movement during eating and swallowing (a novel procedure for measuring texture-related behaviour). International Journal of Food Science and Technology, 30(4), 415–423. https://doi.org/10.1111/j.1365-2621.1995.tb01389.x
- Jaffer, N. M., Ng, E., Au, F. W., & Steele, C. M. (2015). Fluoroscopic evaluation of oropharyngeal dysphagia: Anatomic, technical, and common etiologic factors. American Journal of Roentgenology, 204, 49–58. https://doi.org/10.2214/AJR.13.12374
- Kajee, Y., Pelteret, J. P., & Reddy, B. D. (2013). The biomechanics of the human tongue. International Journal for Numerical Methods in Biomedical Engineering, 29(4), 492–514. https://doi.org/10.1002/cnm.2531
- Kikuchi, T., Michiwaki, Y., Kamiya, T., Toyama, Y., Tamai, T., & Koshizuka, S. (2015). Human swallowing simulation based on video fluorography images using Hamiltonian MPS method. Computational Particle Mechanics, 2(3), 247–260. https://doi.org/10.1007/s40571-015-0049-4
- Kim, Y. H., Jeong, G. Y., & Yoo, B. (2018). Comparative study of IDDSI flow test and line-spread test of thickened water prepared with different dysphagia thickeners. Journal of texture studies, 49(6), 653–658. https://doi.org/10.1111/jtxs.12360
10.1111/jtxs.12360 Google Scholar
- Kunieda, K., Ohno, T., Fujishima, I., Hojo, K., & Morita, T. (2013). Reliability and validity of a tool to measure the severity of dysphagia: The food intake level scale. Journal of Pain & Symptom Management, 46(2), 201–206.
- Lulich, S. M., Berkson, K. H., & de Jong, K. (2018). Acquiring and visualizing 3D/4D ultrasound recordings of tongue motion. Journal of Phonetics, 71, 410–424. https://doi.org/10.1016/j.wocn.2018.10.001
- Matsubara, K., Kumai, Y., Samejima, Y., & Yumoto, E. (2014). Propagation curve and velocity of swallowing pressure in healthy young adults. Dysphagia, 30(6), 674–679. https://doi.org/10.1007/s00455-015-9643-0
- Michiwaki, Y., Kamiya, T., Kikuchi, T., Toyama, Y., Takai, M., Hanyu, K., … Koshizuka, S. (2020). Realistic computer simulation of bolus flow during swallowing. Food Hydrocolloids, 108, 106040. https://doi.org/10.1016/j.foodhyd.2020.106040
- Minagi, Y., Ono, T., Hori, K., Fujiwara, S., Tokuda, Y., Murakami, K., … Mochizuki, H. (2018). Relationships between dysphagia and tongue pressure during swallowing in Parkinson's disease patients. Journal of Oral Rehabilitation, 45(6), 459–466. https://doi.org/10.1111/joor.12626
- Ono, T., Hori, K., & Nokubi, T. (2004). Pattern of tongue pressure on hard palate during swallowing. Dysphagia, 19, 259–264. https://doi.org/10.1007/BF02638592
- Payne, M., & Morley, J. E. (2018). Dysphagia, dementia and frailty. Journal of Nutrition Health & Aging, 22(5), 562–565. https://doi.org/10.1007/s12603-018-1033-5
- Pi, X. (1994). Oral anatomy physiology (third edition). Beijing, China: People's medical publishing house.
- Qazi, W. M., Ekberg, O., Wiklund, J., Kotze, R., & Stading, M. (2019). Assessment of the food-swallowing process using bolus visualisation and manometry simultaneously in a device that models human swallowing. Dysphagia, 34, 821–833. https://doi.org/10.1007/s00455-019-09995-8
- Redfearn, A. G., & Hanson, B. (2018). A mechanical simulator of tongue-palate compression to investigate the oral flow of non-Newtonian fluids. IEEE/ASME Transactions on Mechatronics, 23(2), 958–965. https://doi.org/10.1109/TMECH.2018.2808704
- Saitoh, E., Shibata, S., Matsuo, K., Baba, M., Fujii, W., & Palmer, J. B. (2007). Chewing and food consistency: Effects on bolus transport and swallow initiation. Dysphagia, 22(2), 100–107. https://doi.org/10.1007/s00455-006-9060-5
- Sasegbon, A., & Hamdy, S. (2017). The anatomy and physiology of normal and abnormal swallowing in oropharyngeal dysphagia. Neurogastroenterology and Motility, 29(11), e13100. https://doi.org/10.1111/nmo.13100
- Scott, M. S., Irina, D., Jeremy, M. F., & Khan, A. (2017). Dysphagia in the elderly. Current Treatment Options in Gastroenterology, 15(3), 382–396. https://doi.org/10.1007/s11938-017-0144-0
- Shapiro, J. (2000). Evaluation and treatment of swallowing disorders. Comprehensive Therapy, 26(3), 203–209. https://doi.org/10.1007/s12019-000-0010-0
- Shitara, S., Fujiwara, S., Okawa, J., Kodama, S., Hori, K., & Ono, T. (2020). Coordination between lingual motion and pressure production during dipper/tipper type swallows. Journal of Oral Rehabilitation, 47(12), 1479–1488. https://doi.org/10.1111/joor.13079
- Silbergleit, A. K., Schultz, L., Jacobson, B. H., Beardsley, T., & Johnson, A. F. (2012). The dysphagia handicap index: Development and validation. Dysphagia, 27(1), 46–52. https://doi.org/10.1007/s00455-011-9336-2
- Steiner, I., Le Maguer, S., & Hewer, A. (2017). Synthesis of tongue motion and acoustics from text using a multimodal articulatory database. IEEE-Acm Transactions on Audio Speech and Language Processing, 25(12), 2351–2361. https://doi.org/10.1109/TASLP.2017.2756818
- Su, M., Zheng, G., Chen, Y., Xie, H., Han, W., Yang, Q., … Chen, J. (2017). Clinical applications of IDDSI framework for texture recommendation for dysphagia patients. Journal of Texture Studies, 49(1), 2–10. https://doi.org/10.1111/jtxs.12306
- Tamine, K., Ono, T., Hori, K., Kondoh, J., Hamanaka, S., & Maeda, Y. (2010). Age-related changes in tongue pressure during swallowing. Journal of Dental Research, 89(10), 1097–1101. https://doi.org/10.1177/0022034510370801
- Woo, J., Xing, F. X., Stone, M., Woo, J. G. J., Xing, F., Stone, M., … El Fakhri, G. (2019). Speech map: A statistical multimodal atlas of 4D tongue motion during speech from tagged and cine MR images. Computer Methods in Biomechanics and Biomedical Engineering-Imaging and Visualization, 7(4), 361–373. https://doi.org/10.1080/21681163.2017.1382393
- Wu, Y. (2020). Bionic design and experimental investigation for oral swallowing[D]. Wuxi: Jiangnan University.
- Yang, Y. H., Wang, J. Y., Zhou, S. C., & Tian, H. (2019). Design of a novel coaxial eccentric indexing cam mechanism. Mechanism and Machine Theory, 132, 1–12. https://doi.org/10.1016/j.mechmachtheory.2018.10.012
