Generalized pustular psoriasis-like widespread eruption following COVID-19 infection in a patient with spondyloarthropathy on adalimumab
Kanika Kamal
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorGrant J. Riew
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorBaraa Hijaz
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorSimon M. Helfgott
Harvard Medical School, Boston, Massachusetts, USA
Department of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Search for more papers by this authorAlvaro C. Laga
Harvard Medical School, Boston, Massachusetts, USA
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Search for more papers by this authorCorresponding Author
Vinod E. Nambudiri
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA
Correspondence
Vinod E. Nambudiri, Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Ave, Boston, MA 02115, USA.
Email: [email protected]
Search for more papers by this authorKanika Kamal
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorGrant J. Riew
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorBaraa Hijaz
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA
Search for more papers by this authorSimon M. Helfgott
Harvard Medical School, Boston, Massachusetts, USA
Department of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Search for more papers by this authorAlvaro C. Laga
Harvard Medical School, Boston, Massachusetts, USA
Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Search for more papers by this authorCorresponding Author
Vinod E. Nambudiri
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Harvard Medical School, Boston, Massachusetts, USA
Correspondence
Vinod E. Nambudiri, Department of Dermatology, Brigham and Women's Hospital, 221 Longwood Ave, Boston, MA 02115, USA.
Email: [email protected]
Search for more papers by this authorAbstract
Generalized pustular psoriasis (GPP) is a form of pustular psoriasis that is distinguished by recurring or persistent outbreaks of non-acral primary sterile pustules. These eruptions can occur with or without systemic inflammation. Various factors, such as medications, stress and viral infection, have been identified as potential triggers for GPP flares. While several cases have detailed GPP-like eruptions in the setting of coronavirus disease 2019 (COVID-19) infection, few have explored the interplay between infection and biologic use in the development of GPP. In this case, we detail the history and management of a 45-year-old male patient with a prior history of spondyloarthropathy managed on a tumour necrosis factor-α inhibitor and recent COVID-19 infection presenting with a new, spreading pustular rash.
CONFLICT OF INTEREST STATEMENT
The authors have no conflict of interest to declare.
Open Research
DATA AVAILABILITY STATEMENT
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
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