Effects of CASZ1, WNT2B and PTPRG SNPs on stroke susceptibility in the Chinese Han population
Huan Zhang
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Department of Neurology, The First Hospital of Xi’an, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China
Search for more papers by this authorYanting Chang
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Department of Neurology, The First Hospital of Xi’an, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China
Search for more papers by this authorYujie Li
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Search for more papers by this authorJie Wei
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Search for more papers by this authorXiaoya Ma
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Search for more papers by this authorWenqian Zhou
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Search for more papers by this authorXufeng Zang
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Search for more papers by this authorCorresponding Author
Tianbo Jin
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Correspondence
Songdi Wu, Department of Neurology, The First Hospital of Xi’an, The First Affiliated Hospital of Northwest University, Xi'an City South Street powder Lane No. 30, Xi'an, 710002, Shaanxi, China.
Email: [email protected]
Tianbo Jin, College of Life Science, Northwest University, #229 North TaiBai Road, Xi'an, 710069, Shaanxi, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Songdi Wu
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Department of Neurology, The First Hospital of Xi’an, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China
Correspondence
Songdi Wu, Department of Neurology, The First Hospital of Xi’an, The First Affiliated Hospital of Northwest University, Xi'an City South Street powder Lane No. 30, Xi'an, 710002, Shaanxi, China.
Email: [email protected]
Tianbo Jin, College of Life Science, Northwest University, #229 North TaiBai Road, Xi'an, 710069, Shaanxi, China.
Email: [email protected]
Search for more papers by this authorHuan Zhang
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Department of Neurology, The First Hospital of Xi’an, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China
Search for more papers by this authorYanting Chang
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Department of Neurology, The First Hospital of Xi’an, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China
Search for more papers by this authorYujie Li
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Search for more papers by this authorJie Wei
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Search for more papers by this authorXiaoya Ma
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Search for more papers by this authorWenqian Zhou
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Search for more papers by this authorXufeng Zang
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Search for more papers by this authorCorresponding Author
Tianbo Jin
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), School of Life Sciences, Ministry of Education, Northwest University, Xi'an, Shaanxi, China
Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China
Correspondence
Songdi Wu, Department of Neurology, The First Hospital of Xi’an, The First Affiliated Hospital of Northwest University, Xi'an City South Street powder Lane No. 30, Xi'an, 710002, Shaanxi, China.
Email: [email protected]
Tianbo Jin, College of Life Science, Northwest University, #229 North TaiBai Road, Xi'an, 710069, Shaanxi, China.
Email: [email protected]
Search for more papers by this authorCorresponding Author
Songdi Wu
College of Life Science, Northwest University, Xi'an, Shaanxi, China
Department of Neurology, The First Hospital of Xi’an, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China
Correspondence
Songdi Wu, Department of Neurology, The First Hospital of Xi’an, The First Affiliated Hospital of Northwest University, Xi'an City South Street powder Lane No. 30, Xi'an, 710002, Shaanxi, China.
Email: [email protected]
Tianbo Jin, College of Life Science, Northwest University, #229 North TaiBai Road, Xi'an, 710069, Shaanxi, China.
Email: [email protected]
Search for more papers by this authorAbstract
Background
Stroke is an important cause of death and disability worldwide, ranking second in the cause of death, and it is thought to be related to genetic factors. The purpose of our study is to investigate the association between CASZ1, WNT2B and PTPRG single nucleotide polymorphisms (SNPs) and stroke risk in the Chinese population.
Methods
We recruited 1418 volunteers, comprised of 710 stroke cases and 708 controls in this study. We used MassARRAY iPLEX GOLD method to genotype the three SNPs on CASZ1, WNT2B and PTPRG. Logistic regression was used to analyse the association between these SNPs and stroke, and odds ratios (ORs) and 95% confidence intervals (CIs) were then calculated. What's more, the interactions among SNPs were predicted by multi-factor dimensionality reduction (MDR) analysis.
Results
This research demonstrated that CASZ1 rs880315 and PTPRG rs704341 were associated with reduced stroke susceptibility. More precisely, CASZ1 rs880315 was associated with reduced stroke susceptibility in people aged ≤64 years and women. PTPRG rs704341 was associated with reduced stroke susceptibility in people aged >64 years, women, non-smokers and non-drinkers. Conversely, WNT2B rs12037987 was related to elevated stroke susceptibility in people aged >64 years, women and non-smokers. In addition, CASZ1 rs880315, WNT2B rs12037987 and PTPRG rs704341 had a strong redundancy relationship.
Conclusion
Our study concludes that CASZ1 rs880315, WNT2B rs12037987 and PTPRG rs704341 are associated with stroke, and the study provides a basis for assessing genetic variants associated with stroke risk in the Han Chinese population.
CONFLICT OF INTEREST STATEMENT
The authors have declared that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Supporting Information
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| eci14144-sup-0001-TableS1-S4.docxWord 2007 document , 41.1 KB |
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Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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