Three novel structural variations at the major histocompatibility complex and IL12B predispose to psoriasis*
Q. Zhen
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Contribution: Methodology (equal), Project administration (equal), Resources (lead), Validation (equal), Writing - review & editing (lead)
Search for more papers by this authorY. Zhang
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Search for more papers by this authorY. Yu
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Contribution: Conceptualization (equal), Resources (equal), Validation (equal), Writing - review & editing (equal)
Search for more papers by this authorH. Yang
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Contribution: Data curation (equal), Methodology (equal), Software (lead), Writing - original draft (equal)
Search for more papers by this authorT. Zhang
Department of Biology, University of Copenhagen, Copenhagen, Denmark
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Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
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Search for more papers by this authorX. Mo
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Contribution: Software (equal), Validation (equal)
Search for more papers by this authorB. Li
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
The Comprehensive Lab, College of Basic, Anhui Medical University, Hefei, China
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Department of Dermatology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China
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Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
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Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Contribution: Methodology (equal), Validation (equal)
Search for more papers by this authorQ. Xu
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Search for more papers by this authorW. Chen
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Contribution: Methodology (equal), Validation (supporting)
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Institute of Dermatology, Guangzhou Medical University, Guangzhou, China
Contribution: Methodology (supporting), Validation (supporting)
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Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Search for more papers by this authorG. Chen
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Contribution: Methodology (supporting), Validation (supporting)
Search for more papers by this authorB. Bai
Department of Dermatology at No.2 Hospital, Harbin Medical University, Harbin, Heilongjiang, China
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Department of Dermatology, The 195 Hospital of Chinese People’s Liberation Army, Xianning, Hubei, China
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Dermatology Department of the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
Contribution: Resources (equal)
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Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Search for more papers by this authorH. Zhang
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Search for more papers by this authorY. Zhang
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
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Department of Dermatology at Chengdu Second People's Hospital, Sichuan, Chengdu, China
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Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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School of Medicine, South China University of Technology, Guangzhou, Guangdong, China
Contribution: Methodology (supporting), Software (supporting)
Search for more papers by this authorX. Lin
Department of Neurology and Institute of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
Contribution: Resources (equal)
Search for more papers by this authorL. Yong
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Contribution: Methodology (supporting), Validation (supporting)
Search for more papers by this authorM. Fang
Key Laboratory of Healthy Mariculture for the East China Sea, Ministry of Agriculture, Fisheries College, Jimei University, Xiamen, Fujian, China
Contribution: Resources (equal)
Search for more papers by this authorJ. Zhao
Department of Dermatology, People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, Urumqi, China
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Search for more papers by this authorY. Lu
Department of Dermatology at Chengdu Second People's Hospital, Sichuan, Chengdu, China
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Urology Institute of Shenzhen University, The Luohu Affiliated Hospital of Shenzhen University, Shenzhen, China
Search for more papers by this authorD. Jiang
Key Laboratory of Healthy Mariculture for the East China Sea, Ministry of Agriculture, Fisheries College, Jimei University, Xiamen, Fujian, China
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Department of Dermatology at the Second Affiliated Hospital, Baotou Medical College, University of Science and Technology of The Inner Mongolia, Baotou, Inner Mongolia, China
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Search for more papers by this authorH. Cao
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
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Department of Dermatology, Jining No. 1 People's Hospital, Shandong, China
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Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
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Department of Dermatology, People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, Urumqi, China
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Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
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Department of Dermatology, the 2nd Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China
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Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
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Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
Contribution: Resources (equal)
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Department of Neurology and Institute of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
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Search for more papers by this authorM. Bai
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
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Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, Jining, Shandong, China
Contribution: Resources (equal)
Search for more papers by this authorC. Lv
Dalian Dermatosis Hospital, Dalian, Liaoning, China
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Department of Dermatology at No.1 Hospital of Jilin University, Changchun, Jilin, China
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Dermatology Hospital, Peking Union Medical College, Beijing, China
Search for more papers by this authorF. Li
Department of Dermatology, The Second Hospital of Jilin University, Changchun, China
Contribution: Resources (equal)
Search for more papers by this authorY. Li
Department of Dermatology, The 195 Hospital of Chinese People’s Liberation Army, Xianning, Hubei, China
Search for more papers by this authorCorresponding Author
L. Sun
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Correspondence
Liangdan Sun.
Email: [email protected]
Contribution: Data curation (lead), Funding acquisition (lead), Project administration (lead), Resources (lead), Supervision (lead), Writing - review & editing (equal)
Search for more papers by this authorQ. Zhen
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Contribution: Methodology (equal), Project administration (equal), Resources (lead), Validation (equal), Writing - review & editing (lead)
Search for more papers by this authorY. Zhang
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Search for more papers by this authorY. Yu
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Contribution: Conceptualization (equal), Resources (equal), Validation (equal), Writing - review & editing (equal)
Search for more papers by this authorH. Yang
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Contribution: Data curation (equal), Methodology (equal), Software (lead), Writing - original draft (equal)
Search for more papers by this authorT. Zhang
Department of Biology, University of Copenhagen, Copenhagen, Denmark
Search for more papers by this authorX. Li
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Contribution: Resources (equal)
Search for more papers by this authorX. Mo
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Contribution: Software (equal), Validation (equal)
Search for more papers by this authorB. Li
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
The Comprehensive Lab, College of Basic, Anhui Medical University, Hefei, China
Search for more papers by this authorJ. Wu
Department of Dermatology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, China
Search for more papers by this authorY. Liang
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Contribution: Formal analysis (equal), Software (equal)
Search for more papers by this authorH. Ge
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Contribution: Methodology (equal), Validation (equal)
Search for more papers by this authorQ. Xu
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Search for more papers by this authorW. Chen
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Contribution: Methodology (equal), Validation (supporting)
Search for more papers by this authorW. Qian
Institute of Dermatology, Guangzhou Medical University, Guangzhou, China
Contribution: Methodology (supporting), Validation (supporting)
Search for more papers by this authorH. Xu
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Search for more papers by this authorG. Chen
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Contribution: Methodology (supporting), Validation (supporting)
Search for more papers by this authorB. Bai
Department of Dermatology at No.2 Hospital, Harbin Medical University, Harbin, Heilongjiang, China
Search for more papers by this authorJ. Zhang
Department of Dermatology, The 195 Hospital of Chinese People’s Liberation Army, Xianning, Hubei, China
Search for more papers by this authorY. Lu
Dermatology Department of the First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China
Contribution: Resources (equal)
Search for more papers by this authorS. Chen
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Search for more papers by this authorH. Zhang
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Search for more papers by this authorY. Zhang
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
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Department of Dermatology at Chengdu Second People's Hospital, Sichuan, Chengdu, China
Contribution: Resources (equal)
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Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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School of Medicine, South China University of Technology, Guangzhou, Guangdong, China
Contribution: Methodology (supporting), Software (supporting)
Search for more papers by this authorX. Lin
Department of Neurology and Institute of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
Contribution: Resources (equal)
Search for more papers by this authorL. Yong
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Contribution: Methodology (supporting), Validation (supporting)
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Key Laboratory of Healthy Mariculture for the East China Sea, Ministry of Agriculture, Fisheries College, Jimei University, Xiamen, Fujian, China
Contribution: Resources (equal)
Search for more papers by this authorJ. Zhao
Department of Dermatology, People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, Urumqi, China
Contribution: Resources (equal)
Search for more papers by this authorY. Lu
Department of Dermatology at Chengdu Second People's Hospital, Sichuan, Chengdu, China
Contribution: Resources (equal)
Search for more papers by this authorS. Wu
Urology Institute of Shenzhen University, The Luohu Affiliated Hospital of Shenzhen University, Shenzhen, China
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Key Laboratory of Healthy Mariculture for the East China Sea, Ministry of Agriculture, Fisheries College, Jimei University, Xiamen, Fujian, China
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Department of Dermatology at the Second Affiliated Hospital, Baotou Medical College, University of Science and Technology of The Inner Mongolia, Baotou, Inner Mongolia, China
Contribution: Resources (equal)
Search for more papers by this authorH. Cao
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
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Department of Dermatology, Jining No. 1 People's Hospital, Shandong, China
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Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
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Department of Dermatology, People’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, Urumqi, China
Contribution: Resources (equal)
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Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Contribution: Methodology (supporting), Software (supporting)
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Department of Dermatology, the 2nd Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China
Contribution: Resources (equal)
Search for more papers by this authorS. Sun
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
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Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China
Contribution: Resources (equal)
Search for more papers by this authorW. Chen
Department of Neurology and Institute of Neurology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
Contribution: Methodology (equal), Validation (supporting)
Search for more papers by this authorM. Bai
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Search for more papers by this authorW. Li
Collaborative Innovation Center for Birth Defect Research and Transformation of Shandong Province, Jining Medical University, Jining, Shandong, China
Contribution: Resources (equal)
Search for more papers by this authorC. Lv
Dalian Dermatosis Hospital, Dalian, Liaoning, China
Contribution: Resources (equal)
Search for more papers by this authorS. Li
Department of Dermatology at No.1 Hospital of Jilin University, Changchun, Jilin, China
Search for more papers by this authorM. Chen
Dermatology Hospital, Peking Union Medical College, Beijing, China
Search for more papers by this authorF. Li
Department of Dermatology, The Second Hospital of Jilin University, Changchun, China
Contribution: Resources (equal)
Search for more papers by this authorY. Li
Department of Dermatology, The 195 Hospital of Chinese People’s Liberation Army, Xianning, Hubei, China
Search for more papers by this authorCorresponding Author
L. Sun
Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei, China
Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, China
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China
Anhui Provincial Institute of Translational Medicine, Hefei, China
Correspondence
Liangdan Sun.
Email: [email protected]
Contribution: Data curation (lead), Funding acquisition (lead), Project administration (lead), Resources (lead), Supervision (lead), Writing - review & editing (equal)
Search for more papers by this authorPlain language summary available online
Summary
Background
Structural variations (SVs; defined as DNA variants ≥ 50 base pairs) have been associated with various complex human diseases. However, research to screen the whole genome for SVs predisposing to psoriasis is lacking.
Objectives
To investigate the association of SVs and psoriasis.
Methods
Using imputation, we performed a genome-wide screen of SVs on five independent cohorts with 45 386 participants from the Han Chinese population. Fine-mapping analysis, genetic interaction analysis and RNA expression analysis were conducted to explore the mechanism of SVs.
Results
In total, we obtained 4535 SVs and identified two novel deletions [esv3608550, odds ratio (OR) 2·73 (P < 2·00 × 10–308); esv3608542, OR 0·47 (P = 7·40 × 10–28)] at 6q21·33 (major histocompatibility complex), one novel Alu element insertion [esv3607339; OR 1·22 (P = 1·18 × 10–35)] at 5q33·3 (IL12B) and confirmed one previously reported deletion [esv3587563; OR 1·30 (P = 9·52 × 10–60)] at 1q21·2 (late cornified envelope) for psoriasis. Fine-mapping analysis including single-nucleotide polymorphisms (SNPs) and small insertions/deletions revealed that esv3608550 and esv3608542 were independently associated with psoriasis, and a novel independent SNP [rs9378188; OR, 1·65 (P = 3·46 × 10–38)] was identified at 6q21·33. By genetic interaction analysis and RNA expression analysis, we speculate that the association of two deletions at 6q21·33 with psoriasis might relate to their influence on the expression of HLA-C.
Conclusions
We have constructed the most comprehensive SV map for psoriasis thus far and enriched the genetic architecture and pathogenesis of psoriasis, and highlight the non-negligible impact of SVs on complex diseases.
Supporting Information
| Filename | Description |
|---|---|
| bjd20752-sup-0001-AppendixS1.docxWord 2007 document , 29.3 KB | Appendix S1 Additional methods (including Tables S8–S10 and Figures S14–S18). |
| bjd20752-sup-0002-TablesS1-S10.xlsxExcel 2007 spreadsheet , 28.5 KB |
Table S1 Structural variation calling performance in 24 CHB samples and an independent validation. Table S2 Concordance rates of all structural variations between different cohorts. Table S3 Concordance rates of common structural variations between different cohorts. Table S4 Conditional analysis of 6q21.33 (major histocompatibility complex) locus in the 11M Capture cohort. Table S5 Genetic interaction analysis between structural variations and HLA-C*06:02 in the 11M Capture cohort. Table S6 Expression level of candidate genes in the 1000 Genomes Project. Table S7 Difference in mRNA expression of the seven genes near significant structural variations between lesional psoriatic and normal skin. Table S8 General and clinical characteristics of new samples for the ZhongHua microarray cohort. Table S9 General and clinical characteristics of new samples for the GSA microarray cohort. Table S10 Polymerase chain reaction primers for the validation of structural variations. |
| bjd20752-sup-0003-FigureS1.docxWord 2007 document , 103.2 KB | Figure S1 Study design. |
| bjd20752-sup-0004-FigureS2.docxWord 2007 document , 264.7 KB | Figure S2 Venn plot of all structural variations in five cohorts. |
| bjd20752-sup-0005-FigureS3.docxWord 2007 document , 574.5 KB | Figure S3 Structural variation allele frequency comparison between the present datasets and the 1000 Genomes Project dataset. |
| bjd20752-sup-0006-FigureS4.docxWord 2007 document , 214.1 KB | Figure S4 Manhattan and QQ plot for the 11M Capture cohort. |
| bjd20752-sup-0007-FigureS5.docxWord 2007 document , 221 KB | Figure S5 Manhattan and QQ plot for the ZhongHua microarray cohort. |
| bjd20752-sup-0008-FigureS6.docxWord 2007 document , 237.1 KB | Figure S6 Manhattan and QQ plot for the Global Screening Array (GSA) microarray cohort. |
| bjd20752-sup-0009-FigureS7.docxWord 2007 document , 214.1 KB | Figure S7 Manhattan and QQ plot for the 610 microarray cohort. |
| bjd20752-sup-0010-FigureS8.docxWord 2007 document , 212.8 KB | Figure S8 Manhattan and QQ plot for the whole-exome sequencing cohort. |
| bjd20752-sup-0011-FigureS9.docxWord 2007 document , 381.6 KB | Figure S9 Conditional association in the 11M Capture cohort. |
| bjd20752-sup-0012-FigureS10.docxWord 2007 document , 519.7 KB | Figure S10 Conditional association in the ZhongHua microarray cohort. |
| bjd20752-sup-0013-FigureS11.docxWord 2007 document , 442.7 KB | Figure S11 Conditional association in the Global Screening Array (GSA) microarray cohort. |
| bjd20752-sup-0014-FigureS12.docxWord 2007 document , 257.7 KB | Figure S12 Regional association in 610 microarray cohort. |
| bjd20752-sup-0015-FigureS13.docxWord 2007 document , 175 KB | Figure S13 Regional association in the whole-exome sequencing cohort. |
| bjd20752-sup-0016-FigureS14.docxWord 2007 document , 214.7 KB | Figure S14 Principal component analysis plot of the 11M Capture cohort. |
| bjd20752-sup-0017-FigureS15.docxWord 2007 document , 294.3 KB | Figure S15 Principal component analysis plot of the ZhongHua microarray cohort. |
| bjd20752-sup-0018-FigureS16.docxWord 2007 document , 160.8 KB | Figure S16 Principal component analysis plot of Global Screening Array (GSA) microarray cohort. |
| bjd20752-sup-0019-FigureS17.docxWord 2007 document , 269.1 KB | Figure S17 Principal component analysis plot of 610 microarray cohort. |
| bjd20752-sup-0020-FigureS18.docxWord 2007 document , 190.8 KB | Figure S18 Principal component analysis plot of the whole-exome sequencing cohort. |
| bjd20752-sup-0021-VideoS1.mp4MPEG-4 video, 10.2 MB | Video S1 Author video. |
| bjd20752-sup-0022-PowerpointS1.pptxapplication/ms-powerpoint, 6 MB | Powerpoint S1 Journal Club Slide Set. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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