Volume 90, Issue 12 pp. E172-E176

ENDOCRINE SURGERY

Selective intra-arterial calcium stimulation test for the localization of insulinomas: an Australian hospital experience

Anneke Graf,

Anneke Graf

Department of Diabetes and Endocrinology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

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Stella Sarlos,

Stella Sarlos

Department of Endocrinology, Monash Health, Clayton, Victoria, Australia

Department of Medicine, Monash University, Clayton, Victoria, Australia

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Stephen G. Farrell,

Stephen G. Farrell

Department of Surgery, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

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Richard J. MacIsaac,

Richard J. MacIsaac

Department of Diabetes and Endocrinology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

Department of Medicine St Vincent's Hospital Melbourne, University of Melbourne, Fitzroy, Victoria, Australia

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Warrick J. Inder,

Warrick J. Inder

Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Queensland, Australia

Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia

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Nirupa Sachithanandan,

Corresponding Author

Nirupa Sachithanandan

[email protected]

Department of Diabetes and Endocrinology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

Department of Medicine St Vincent's Hospital Melbourne, University of Melbourne, Fitzroy, Victoria, Australia

Correspondence

Dr Nirupa Sachithanandan, Department of Diabetes and Endocrinology, St Vincent's Hospital Melbourne, 41 Victoria Street, Fitzroy, Melbourne, VIC 3065, Australia. Email: [email protected]

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Anneke Graf,

Anneke Graf

Department of Diabetes and Endocrinology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

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Stella Sarlos,

Stella Sarlos

Department of Endocrinology, Monash Health, Clayton, Victoria, Australia

Department of Medicine, Monash University, Clayton, Victoria, Australia

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Stephen G. Farrell,

Stephen G. Farrell

Department of Surgery, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

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Richard J. MacIsaac,

Richard J. MacIsaac

Department of Diabetes and Endocrinology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

Department of Medicine St Vincent's Hospital Melbourne, University of Melbourne, Fitzroy, Victoria, Australia

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Warrick J. Inder,

Warrick J. Inder

Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Queensland, Australia

Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia

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Nirupa Sachithanandan,

Corresponding Author

Nirupa Sachithanandan

[email protected]

Department of Diabetes and Endocrinology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia

Department of Medicine St Vincent's Hospital Melbourne, University of Melbourne, Fitzroy, Victoria, Australia

Correspondence

Dr Nirupa Sachithanandan, Department of Diabetes and Endocrinology, St Vincent's Hospital Melbourne, 41 Victoria Street, Fitzroy, Melbourne, VIC 3065, Australia. Email: [email protected]

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First published: 01 May 2020

https://doi.org/10.1111/ans.15913

Citations: 4

A. Graf MBBS, FRACP; S. Sarlos FRACP, PhD; S. G. Farrell MBBS, FRACS; R. J. MacIsaac FRACP, PhD; W. J. Inder FRACP, MD; N. Sachithanandan FRACP, PhD.

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Abstract

Background

Insulinomas are rare tumours of the pancreas and the most common cause of hypoglycaemia in non-diabetic adults. They can be cured by surgery but require precise localization. The aim of this study was to assess the utility of the selective intra-arterial calcium stimulation test (SIACST) in patients with an insulinoma to correctly localize the tumour.

Methods

Medical records of patients with a diagnosis of insulinoma or who underwent an SIACST were retrospectively reviewed. Localization of lesions by SIACST was compared to endoscopic ultrasound and radionuclide imaging studies and verified against findings at surgery.

Results

A total of 24 patients (mean age 58 years, 16 females, 20 with insulinoma) underwent SIACST. The SIACST correctly localized the insulinoma in 17 of 20 patients (85%). Localization rate for computed tomography was 55% and 75% for endoscopic ultrasound and glucagon-like peptide-1 receptor scan.

Conclusion

SIACST provided incremental diagnostic information in patients with insulinoma who had equivocal non-invasive imaging preoperatively. This technique remains an essential diagnostic tool when a lesion is not localized by other methods.

Conflicts of interest

None declared.

Supporting Information

References

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Volume90, Issue12

December 2020

Pages E172-E176

Selective intra-arterial calcium stimulation test for the localization of insulinomas: an Australian hospital experience

Abstract

Background

Methods

Results

Conclusion

Conflicts of interest

Supporting Information

References

Citing Literature

References

Information

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Selective intra-arterial calcium stimulation test for the localization of insulinomas: an Australian hospital experience

Abstract

Background

Methods

Results

Conclusion

Conflicts of interest

Supporting Information

References

Citing Literature

References

Related

Information