Review
Microbial dysbiosis in the gut–mammary axis as a mechanism for mastitis in dairy cows
Zhiwei Wang,
Zheng Ma,
Zhichen Tian,
Haoran Jia,
Lei Zhang,
Yongjiang Mao,
Zhangping Yang,
Xu Liu,
Mingxun Li,
Zhiwei Wang
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Contribution: Writing - original draft
Search for more papers by this authorZheng Ma
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Contribution: Supervision
Search for more papers by this authorZhichen Tian
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Contribution: Supervision
Search for more papers by this authorHaoran Jia
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Contribution: Investigation
Search for more papers by this authorLei Zhang
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Contribution: Investigation
Search for more papers by this authorYongjiang Mao
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Contribution: Writing - review & editing
Search for more papers by this authorZhangping Yang
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Contribution: Writing - review & editing
Search for more papers by this authorXu Liu
College of Veterinary Medicine, Northwest A&F University, Yangling, Shanxi, 712100 China
Contribution: Writing - review & editing
Search for more papers by this authorCorresponding Author
Mingxun Li
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education, Yangzhou University, Yangzhou, Jiangsu, 225009 China
*Author for correspondence. E-mail: [email protected]
Contribution: Writing - review & editing
Search for more papers by this authorZhiwei Wang,
Zheng Ma,
Zhichen Tian,
Haoran Jia,
Lei Zhang,
Yongjiang Mao,
Zhangping Yang,
Xu Liu,
Mingxun Li,
Zhiwei Wang
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Contribution: Writing - original draft
Search for more papers by this authorZheng Ma
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Contribution: Supervision
Search for more papers by this authorZhichen Tian
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Contribution: Supervision
Search for more papers by this authorHaoran Jia
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Contribution: Investigation
Search for more papers by this authorLei Zhang
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Contribution: Investigation
Search for more papers by this authorYongjiang Mao
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Contribution: Writing - review & editing
Search for more papers by this authorZhangping Yang
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Contribution: Writing - review & editing
Search for more papers by this authorXu Liu
College of Veterinary Medicine, Northwest A&F University, Yangling, Shanxi, 712100 China
Contribution: Writing - review & editing
Search for more papers by this authorCorresponding Author
Mingxun Li
College of Animal Science and Technology, Yangzhou University, Yangzhou, Jiangsu, 225009 China
Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education, Yangzhou University, Yangzhou, Jiangsu, 225009 China
*Author for correspondence. E-mail: [email protected]
Contribution: Writing - review & editing
Search for more papers by this authorAbstract
Mastitis is a significant and costly disease in dairy cows, reducing milk production and affecting herd health. Recent research highlights the role of gastrointestinal microbial dysbiosis in the development of mastitis. This review focuses on how microbial imbalances in the rumen and intestines can compromise the integrity of the gastrointestinal barriers, allowing harmful bacteria and endotoxins, such as lipopolysaccharide, to enter the bloodstream and reach the mammary gland, triggering inflammation. This process links gastrointestinal health to mammary gland inflammation through the gut–mammary axis. Furthermore, disruptions in glucose metabolism and immune responses are implicated in the progression of mastitis. This review underscores the potential for non-antibiotic interventions aimed at restoring microbial balance to reduce mastitis incidence, providing new insights into improving dairy cow health and farm productivity. Our findings emphasise the critical need to explore preventive measures targeting the rumen and intestinal microbiota for effective mastitis control.
CONFLICT OF INTEREST
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Open Research
DATA AVAILABILITY STATEMENT
Data sharing is not applicable to this article as no datasets were generated or analysed during the current study.
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