Review
Biomimetic Mineralized Collagen Scaffolds for Bone Tissue Engineering: Strategies on Elaborate Fabrication for Bioactivity Improvement
Bingfeng Wu,
Xiaohong Li,
Rui Wang,
Liu Liu,
Dingming Huang,
Ling Ye,
Zhenming Wang,
Bingfeng Wu
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorXiaohong Li
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorRui Wang
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorLiu Liu
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorDingming Huang
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorCorresponding Author
Ling Ye
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
E-mail: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Zhenming Wang
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
E-mail: [email protected]; [email protected]
Search for more papers by this authorBingfeng Wu,
Xiaohong Li,
Rui Wang,
Liu Liu,
Dingming Huang,
Ling Ye,
Zhenming Wang,
Bingfeng Wu
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorXiaohong Li
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorRui Wang
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorLiu Liu
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorDingming Huang
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
Search for more papers by this authorCorresponding Author
Ling Ye
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
E-mail: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Zhenming Wang
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041 China
E-mail: [email protected]; [email protected]
Search for more papers by this authorAbstract
Biomimetic mineralized collagen (BMC) scaffolds represent an innovative class of bone-repair biomaterials inspired by the natural biomineralization process in bone tissue. Owing to their favorable biocompatibility and mechanical properties, BMC scaffolds have garnered significant attention in bone tissue engineering. However, most studies have overlooked the importance of bioactivity, resulting in collagen scaffolds with suboptimal osteogenic potential. In this review, the composition of the mineralized extracellular matrix (ECM) in bone tissue is discussed to provide guidance for biomimetic collagen mineralization. Subsequently, according to the detailed fabrication procedure of BMC scaffolds, the substances that can regulate both the fabrication process and biological activities is summarized. Furthermore, a potential strategy for developing BMC scaffolds with superior mechanical properties and biological activities for bone tissue engineering is proposed.
Conflict of Interest
The authors declare no conflict of interest.
References
- 1R. Dimitriou, E. Jones, D. McGonagle, P. V. Giannoudis, BMC Med. 2011, 9, 66.
- 2J. Wang, Q. Liu, Z. Guo, H. Pan, Z. Liu, R. Tang, ACS Biomater. Sci. Eng. 2023, 9, 1757.
- 3Y. Bai, Z. Wang, X. He, Y. Zhu, X. Xu, H. Yang, G. Mei, S. Chen, B. Ma, R. Zhu, Small Methods 2024, 8, 2301283.
- 4A. Wubneh, E. K. Tsekoura, C. Ayranci, H. Uludağ, Acta Biomater. 2018, 80, 1.
- 5S. P. Soundarya, A. Haritha Menon, S. Viji Chandran, N. Selvamurugan, Int. J. Biol. Macromol. 2018, 119, 1228.
- 6S. Li, X. Dan, H. Chen, T. Li, B. Liu, Y. Ju, Y. Li, L. Lei, X. Fan, Bioact. Mater. 2024, 40, 597.
- 7G. Zhu, T. Zhang, M. Chen, K. Yao, X. Huang, B. Zhang, Y. Li, J. Liu, Y. Wang, Z. Zhao, Bioact. Mater. 2021, 6, 4110.
- 8Y. Zhang, Q. Zhang, C. Li, Z. Zhou, H. Lei, M. Liu, D. Zhang, Drug Deliv. 2024, 31, 2361169.
- 9A. Liang, W. Zhao, T. Lv, Z. Zhu, R. Haotian, J. Zhang, B. Xie, Y. Yi, Z. Hao, L. Sun, A. Luo, Talanta 2024, 280, 126709.
- 10H. You, S. Geng, S. Li, M. Imani, D. Brambilla, T. Sun, C. Jiang, Biomaterials 2024, 311, 122694.
- 11X. Wei, Y. Wang, Y. Liu, K. Ji, K. Li, J. Wang, Z. Gu, Matter 2024, 7, 826.
- 12W. Jiang, Y. Zhan, Y. Zhang, D. Sun, G. Zhang, Z. Wang, L. Chen, J. Sun, Biomaterials 2024, 308, 122566.
- 13X. Zhang, Y. Xia, J. Xu, J. Kang, X. Li, Y. Li, W. Yan, F. Tian, B. Zhao, B. Li, C. Wang, L. Wang, Carbohydr. Polym. 2024, 332, 121945.
- 14M. G. Wiesli, M. W. Huber, B. Weisse, R. Zboray, S. Kiderlen, A. González-Vázquez, K. Maniura-Weber, M. Rottmar, W. A. Lackington, Adv. Healthcare Mater. 2024, https://doi.org/10.1002/adhm.202400077.
- 15Z. Xia, M. M. Villa, M. Wei, J. Mater. Chem. B 2014, 2, 1998.
- 16P. Fratzl, R. Weinkamer, Prog. Mater. Sci. 2007, 52, 1263.
- 17N. Reznikov, R. Shahar, S. Weiner, Acta Biomater. 2014, 10, 3815.
- 18L. Yu, M. Wei, Int. J. Mol. Sci. 2021, 22, 944.
- 19E. Hadjipanayi, M. Ananta, M. Binkowski, I. Streeter, Z. Lu, Z. F. Cui, R. A. Brown, V. Mudera, J. Tissue Eng. Regener. Med. 2011, 5, 505.
- 20B. Sarkar, L. E. R. O'Leary, J. D. Hartgerink, J. Am. Chem. Soc. 2014, 136, 14417.
- 21M. E. Doyle, K. Dalgarno, E. Masoero, A. M. Ferreira, Biopolymers 2023, 114, 23527.
- 22C. Shao, R. Zhao, S. Jiang, S. Yao, Z. Wu, B. Jin, Y. Yang, H. Pan, R. Tang, Adv. Mater. 2018, 30, 1704876.
- 23H. Liu, M. Lin, X. Liu, Y. Zhang, Y. Luo, Y. Pang, H. Chen, D. Zhu, X. Zhong, S. Ma, Y. Zhao, Q. Yang, X. Zhang, Bioact. Mater. 2020, 5, 844.
- 24K. Adamiak, A. Sionkowska, Int. J. Biol. Macromol. 2020, 161, 550.
- 25H. Wu, C. Shao, J. Shi, Z. Hu, Y. Zhou, Z. Chen, R. Tang, Z. Xie, W. Jin, Carbohydr. Polym. 2023, 319, 121174.
- 26L. Wu, Q. Wang, Y. Li, M. Yang, M. Dong, X. He, S. Zheng, C. Y. Cao, Z. Zhou, Y. Zhao, Q.-L. Li, ACS Appl. Mater. Interfaces 2021, 13, 39142.
- 27K. Rasheeda, H. Bharathy, N. N. Fathima, Int. J. Biol. Macromol. 2018, 113, 952.
- 28X. Nie, Y. Shi, L. Wang, W. Abudureheman, J. Yang, C. Lin, Heliyon 2024, 10, 30279.
10.1016/j.heliyon.2024.e30279 Google Scholar
- 29G. Bhattarai, S. Poudel, M. Kim, H. Sim, H. So, S. Kook, J. Lee, Cytotherapy 2019, 21, e8.
10.1016/j.jcyt.2019.04.028 Google Scholar
- 30J. Zhou, X. Guo, Q. Zheng, Y. Wu, F. Cui, B. Wu, Colloids Surf. B Biointerfaces 2017, 152, 124.
- 31J.-X. Hao, M.-J. Shen, C.-Y. Wang, J.-H. Wei, Q.-Q. Wan, Y.-F. Zhu, T. Ye, M.-L. Luo, W.-P. Qin, Y.-T. Li, K. Jiao, B. Zhao, L.-N. Niu, Carbohydr. Polym. 2022, 294, 119773.
- 32Z. Li, T. Du, C. Ruan, X. Niu, Bioact. Mater. 2021, 6, 1491.
- 33W. Zhu, C. Li, M. Yao, X. Wang, J. Wang, W. Zhang, W. Chen, H. Lv, Regen. Biomater. 2023, 10, rbad030.
- 34S. Weiner, H. D. Wagner, Annu. Rev. Mater. Res. 1998, 28, 271.
- 35A. Sorushanova, L. M. Delgado, Z. Wu, N. Shologu, A. Kshirsagar, R. Raghunath, A. M. Mullen, Y. Bayon, A. Pandit, M. Raghunath, D. I. Zeugolis, Adv. Mater. 2019, 31, 1801651.
- 36K. Gelse, E. Pöschl, T. Aigner, Adv. Drug Delivery Rev. 2003, 55, 1531.
- 37A. M. Ferreira, P. Gentile, V. Chiono, G. Ciardelli, Acta Biomater. 2012, 8, 3191.
- 38B. M. Carlson, The Human Body, (Ed: B. M. Carlson), Academic Press, Cambridge, MA, 2019, pp. 27–63.
10.1016/B978-0-12-804254-0.00002-8 Google Scholar
- 39D. J. V. David, Nat. Cell Biol. 2023, 25, 1240.
- 40X. Luo, S. Zhang, B. Luo, H. Li, Int. J. Biol. Macromol. 2021, 185, 77.
- 41F. Nudelman, K. Pieterse, A. George, P. H. H. Bomans, H. Friedrich, L. J. Brylka, P. A. J. Hilbers, G. De With, N. A. J. M. Sommerdijk, Nat. Mater. 2010, 9, 1004.
- 42Z. Xu, Y. Yang, W. Zhao, Z. Wang, W. J. Landis, Q. Cui, N. Sahai, Biomaterials 2015, 39, 59.
- 43K. Ishikawa, K. Hayashi, Sci Technol Adv. Mater. 2021, 22, 683.
- 44T. Kono, T. Sakae, H. Nakada, T. Kaneda, H. Okada, Minerals 2022, 12, 170.
- 45H. Cölfen, Nat. Mater. 2010, 9, 960.
- 46S. Boonrungsiman, E. Gentleman, R. Carzaniga, N. D. Evans, D. W. McComb, A. E. Porter, M. M. Stevens, Proc Natl Acad Sci U S A 2012, 109, 14170.
- 47D. Pei, J. Sun, C. Zhu, F. Tian, K. Jiao, M. R. Anderson, C. Yiu, C. Huang, C. Jin, B. E. Bergeron, J. Chen, F. R. Tay, L. Niu, Adv. Sci. 2018, 5, 1800873.
- 48C. Tang, Y. Wei, L. Gu, Q. Zhang, M. Li, G. Yuan, Y. He, L. Huang, Y. Liu, Y. Zhang, Adv. Sci. 2020, 7, 1902536.
- 49T. Iwayama, P. Bhongsatiern, M. Takedachi, S. Murakami, J. Dent. Res. 2022, 101, 1554.
- 50P. A. Cohen, J. V. Strauss, A. D. Rooney, M. Sharma, N. Tosca, Sci. Adv. 2017, 3, 1700095.
- 51L.-N. Niu, S. E. Jee, K. Jiao, L. Tonggu, M. Li, L. Wang, Y.-D. Yang, J.-H. Bian, L. Breschi, S. S. Jang, J.-H. Chen, D. H. Pashley, F. R. Tay, Nat. Mater. 2017, 16, 370.
- 52H. Liu, H. Zhang, K. Wang, L. Qi, Y. Guo, C. Zhang, Y. Xu, Molecules 2023, 28, 3096.
- 53W. Zhu, K. Li, Q. Liu, H. Zhong, C. Xu, J. Zhang, H. Kou, B. Wei, H. Wang, New J. Chem. 2021, 45, 15863.
- 54H. Tian, Z. Ren, L. Shi, G. Hao, J. Chen, W. Weng, Proc. Biochem. 2021, 108, 153.
- 55L. Han, J. Lin, C. Du, C. Zhang, X. Wang, Q. Feng, J. Funct. Biomater. 2023, 14, 235.
- 56F. Elmi, M. M. Elmi, F. N. Amiri, Food Biophys 2017, 12, 365.
- 57P. Noohi, S. S. Mahdavi, M. J. Abdekhodaie, M. H. Nekoofar, A. Baradaran-Rafii, Materialia 2023, 27, 101651.
- 58D. Gunasekaran, R. Thada, G. F. S. Jeyakumar, N. P. Manimegalai, G. Shanmugam, U. T. Sivagnanam, Int. J. Biol. Macromol. 2020, 165, 2920.
- 59M. Fang, E. L. Goldstein, E. K. Matich, B. G. Orr, M. M. Banaszak Holl, Langmuir 2013, 29, 2330.
- 60R. Usha, T. Ramasami, Thermochim. Acta 2004, 409, 201.
- 61Y. Li, A. Asadi, M. R. Monroe, E. P. Douglas, Mater. Sci. Eng. C 2009, 29, 1643.
- 62L. Shen, H. Bu, H. Yang, W. Liu, G. Li, Int. J. Biol. Macromol. 2018, 115, 635.
- 63C. Yue, C. Ding, J. Su, B. Cheng, Int. J. Polym. Anal. Charact. 2022, 27, 394.
- 64Z. Wang, Q. Xiao, X. Song, Y. Wan, J. Zhu, J. Food Qual. 2017, 2017, 1692975.
10.1155/2017/1692975 Google Scholar
- 65X. Song, Z. Wang, S. Tao, G. Li, J. Zhu, J. Food Qual. 2017, 2017, 9257060.
10.1155/2017/9257060 Google Scholar
- 66X. Niu, R. Fan, F. Tian, X. Guo, P. Li, Q. Feng, Y. Fan, Mater. Sci. Eng. C 2017, 73, 137.
- 67G. Zhang, M. Zhang, Q. Feng, R. Wang, H. Mei, K. Xing, J. Li, ACS Appl. Mater. Interfaces 2024, 16, 45929.
- 68S. Zhu, Q. Yuan, T. Yin, J. You, Z. Gu, S. Xiong, Y. Hu, J. Mater. Chem. B 2018, 6, 2650.
- 69J. Zhang, Y. Huang, W. Liu, L. Xie, B. Wei, C. Xu, Y. Xu, M. Zheng, H. Wang, New J. Chem. 2022, 46, 9264.
- 70E. Boanini, P. Torricelli, M. Gazzano, R. Giardino, A. Bigi, Biomaterials 2006, 27, 4428.
- 71H. Bu, H. Yang, L. Shen, W. Liu, G. Li, Colloids Surf. B Biointerfaces 2020, 190, 110892.
- 72O.-H. Lee, B.-Y. Lee, Bioresour. Technol. 2010, 101, 3751.
- 73H. Bharathy, N. N. Fathima, Int. J. Biol. Macromol. 2017, 101, 179.
- 74Y. A. Kim, Y. S. Tarahovsky, S. G. Gaidin, E. A. Yagolnik, E. N. Muzafarov, Int. J. Biol. Macromol. 2017, 104, 631.
- 75J. Xie, M. Bao, S. M. C. Bruekers, W. T. S. Huck, ACS Appl. Mater. Interfaces 2017, 9, 19630.
- 76Y. Yang, S. Motte, L. J. Kaufman, Biomaterials 2010, 31, 5678.
- 77J. R. Harris, A. Soliakov, R. J. Lewis, Micron 2013, 49, 60.
- 78J. Elango, Y. Bu, B. Bin, J. Geevaretnam, J. S. Robinson, W. Wu, Food Biosci. 2017, 17, 42.
- 79A. Jayakrishnan, S. R. Jameela, Biomaterials 1996, 17, 471.
- 80D. I. Zeugolis, G. R. Paul, G. Attenburrow, J. Biomed. Mater. Res. Part A 2009, 89A, 895.
- 81M. Jastrzebska, R. Wrzalik, A. Kocot, J. Zalewska-Rejdak, B. Cwalina, J. Biomater. Sci., Polym. Ed. 2003, 14, 185.
- 82M. E. Nimni, D. Cheung, B. Strates, M. Kodama, K. Sheikh, J. Biomed. Mater. Res. 1987, 21, 741.
- 83G. Goissis, E. Marcantonio, R. A. C. Marcantônio, R. C. C. Lia, D. C. J. Cancian, W. M. de Carvalho, Biomaterials 1999, 20, 27.
- 84T. Zhang, Z. Yu, Y. Ma, B.-S. Chiou, F. Liu, F. Zhong, Food Hydrocolloids 2022, 124, 107270.
- 85T. Akao, K. Kobashi, M. Aburada, Biol. Pharm. Bull. 1994, 17, 1573.
- 86C. Mu, K. Zhang, W. Lin, D. Li, J. Biomed. Mater. Res. Part A 2013, 101A, 385.
- 87M. J. B. Wissink, R. Beernink, J. S. Pieper, A. A. Poot, G. H. M. Engbers, T. Beugeling, W. G. van Aken, J. Feijen, Biomaterials 2001, 22, 151.
- 88N. Davidenko, C. F. Schuster, D. V. Bax, N. Raynal, R. W. Farndale, S. M. Best, R. E. Cameron, Acta Biomater. 2015, 25, 131.
- 89C. YANG, Bull. Mater. Sci. 2012, 35, 913.
- 90M. Yan, X. An, S. Duan, Z. Jiang, X. Liu, X. Zhao, Y. Li, Int. J. Biol. Macromol. 2022, 213, 639.
- 91H. M. Powell, S. T. Boyce, Biomaterials 2006, 27, 5821.
- 92L. Sun, B. Li, W. Song, K. Zhang, Y. Fan, H. Hou, Mater. Sci. Eng. C 2020, 109, 110532.
- 93M. G. Haugh, M. J. Jaasma, F. J. O'Brien, J. Biomedical Materials Res. 2009, 89A, 363.
- 94D. Cooper, R. Davidson, Biochem. J. 1965, 97, 139.
- 95K. S. Weadock, E. J. Miller, L. D. Bellincampi, J. P. Zawadsky, M. G. Dunn, Journal of Biomedical Materials Research 1995, 29, 1373.
- 96W. Wang, Y. Zhang, R. Ye, Y. Ni, Int. J. Biol. Macromol. 2015, 81, 920.
- 97C. A. Miles, A. J. Bailey, Micron 2001, 32, 325.
- 98E. Suesca, A. M. A. Dias, M. E. M. Braga, H. C. De Sousa, M. R. Fontanilla, Mater. Sci. Eng. C 2017, 77, 333.
- 99C. R. Lee, A. J. Grodzinsky, M. Spector, Biomaterials 2001, 22, 3145.
- 100D. V. Bax, N. Davidenko, S. W. Hamaia, R. W. Farndale, S. M. Best, R. E. Cameron, Acta Biomater. 2019, 100, 280.
- 101H. Wang, Y. Xiao, Z. Fang, Y. Zhang, L. Yang, C. Zhao, Z. Meng, Y. Liu, C. Li, Q. Han, Z. Feng, Int. J. Biol. Macromol. 2023, 251, 126293.
- 102W. Kong, Q. Du, Y. Qu, C. Shao, C. Chen, J. Sun, C. Mao, R. Tang, X. Gu, RSC Adv. 2022, 12, 3454.
- 103J. Gu, K. Jiao, J. Li, J. Yan, K. Wang, F. Wang, Y. Liu, F. R. Tay, J. Chen, L. Niu, Bioact. Mater. 2022, 15, 68.
- 104J. Song, J. Gu, G. Dang, Z. Li, C. Lei, L. Li, Z. Mu, F. R. Tay, K. Jiao, L. Niu, Chem. Eng. J. 2023, 474, 145318.
- 105X. Zhu, C. Wang, H. Bai, J. Zhang, Z. Wang, Z. Li, X. Zhao, J. Wang, H. Liu, Mater. Today Bio 2023, 20, 100660.
- 106B. L. Smith, T. E. Schäffer, M. Viani, J. B. Thompson, N. A. Frederick, J. Kindt, A. Belcher, G. D. Stucky, D. E. Morse, P. K. Hansma, Nature 1999, 399, 761.
- 107D. B. Burr, Bone 2002, 31, 8.
- 108D. W. Weisgerber, S. R. Caliari, B. A. C. Harley, Biomater. Sci. 2015, 3, 533.
- 109Q. Zhou, X. Ren, D. Bischoff, D. W. Weisgerber, D. T. Yamaguchi, T. A. Miller, B. A. C. Harley, J. C. Lee, Adv. Healthcare Mater. 2017, 6, 1700641.
- 110Q. Zhou, S. Lyu, A. A. Bertrand, A. C. Hu, C. H. Chan, X. Ren, M. J. Dewey, A. S. Tiffany, B. A. C. Harley, J. C. Lee, Macromol. Biosci. 2021, 21, 2000370.
- 111X. Ren, V. Tu, D. Bischoff, D. W. Weisgerber, M. S. Lewis, D. T. Yamaguchi, T. A. Miller, B. A. C. Harley, J. C. Lee, Biomaterials 2016, 89, 67.
- 112R. Sridharan, K. J. Genoud, D. J. Kelly, F. J. O'Brien, ACS Appl. Bio Mater. 2020, 3, 7562.
- 113M. J. Olszta, E. P. Douglas, L. B. Gower, Calcif. Tissue Int. 2003, 72, 583.
- 114Y. Liu, Y.-K. Kim, L. Dai, N. Li, S. O. Khan, D. H. Pashley, F. R. Tay, Biomaterials 2011, 32, 1291.
- 115C. Liu, L. Jiang, W. Du, X. Cheng, Z. Zhao, J. Wang, X. Jian, J of Applied Polym. Sci. 2023, 140, e54275.
- 116A. L. Boskey, S. Gadaleta, C. Gundberg, S. B. Doty, P. Ducy, G. Karsenty, Bone 1998, 23, 187.
- 117S. Morgan, A. A. Poundarik, D. Vashishth, Calcif. Tissue Int. 2015, 97, 281.
- 118D. E. Rodriguez, T. Thula-Mata, E. J. Toro, Y.-W. Yeh, C. Holt, L. S. Holliday, L. B. Gower, Acta Biomater. 2014, 10, 494.
- 119T. Moriishi, R. Ozasa, T. Ishimoto, T. Nakano, T. Hasegawa, T. Miyazaki, W. Liu, R. Fukuyama, Y. Wang, H. Komori, X. Qin, N. Amizuka, T. Komori, PLoS Genet. 2020, 16, 1008586.
- 120B. Depalle, C. M. McGilvery, S. Nobakhti, N. Aldegaither, S. J. Shefelbine, A. E. Porter, Acta Biomater. 2021, 120, 194.
- 121N. Saxena, J. Mizels, M. A. Cremer, V. Guarnizo, D. E. Rodriguez, L. B. Gower, Polymers 2022, 14, 775.
- 122C. M. França, G. Thrivikraman, A. Athirasala, A. Tahayeri, L. B. Gower, L. E. Bertassoni, J. Biomed. Mater. Res. B Appl. Biomater. 2019, 107, 1522.
- 123Z. Wang, P. Ustriyana, K. Chen, W. Zhao, Z. Xu, N. Sahai, ACS Biomater. Sci. Eng. 2020, 6, 4247.
- 124M. Tavafoghi, M. Cerruti, J. R. Soc. Interface 2016, 13, 20160462.
- 125L. Luo, H. Uludag, E. Sone, S. Viswanathan, Cytotherapy 2020, 22, S183.
10.1016/j.jcyt.2020.03.384 Google Scholar
- 126C. Hu, M. Zilm, M. Wei, J. Biomed. Mater. Res., Part A 2016, 104, 1153.
- 127C. Hu, L. Zhang, M. Wei, ACS Biomater. Sci. Eng. 2015, 1, 669.
- 128Y. Qi, Z. Ye, A. Fok, B. N. Holmes, M. Espanol, M.-P. Ginebra, C. Aparicio, ACS Biomater. Sci. Eng. 2018, 4, 2758.
- 129M. Lin, H. Liu, J. Deng, R. An, M. Shen, Y. Li, X. Zhang, J. Mater. Sci. Technol. 2019, 35, 1894.
- 130R. Wang, J. Guo, X. Lin, S. Chen, S. Mai, RSC Adv. 2020, 10, 12970.
- 131H. He, C. Shao, Z. Mu, C. Mao, J. Sun, C. Chen, R. Tang, X. Gu, Carbohydr. Polym. 2020, 229, 115547.
- 132W. Su, L. Ma, Y. Ran, X. Ma, Z. Yi, G. Chen, X. Chen, X. Li, ACS Biomater. Sci. Eng. 2020, 6, 3275.
- 133H. Cui, M. J. Webber, S. I. Stupp, Biopolymers 2010, 94, 1.
- 134Q. Wang, L. Miao, H. Zhang, S. Q. Wang, Q. Li, W. Sun, J. Mater. Chem. B 2020, 8, 2350.
- 135A. Bigi, E. Boanini, M. Gazzano, K. Rubini, Cryst. Res. Technol. 2005, 40, 1094.
- 136J. Mt, Y. G, C. M., Journal of the Royal Society, Interface 2012, 10, 20120906.
- 137W. Zheng, D. Xu, M. Wang, Y. Zhang, Q. Gao, Y. Gao, J. Chromatogr. Sci. 2019, 57, 238.
- 138C.-Y. Wang, Z.-X. Qin, Y. Wei, J.-X. Hao, Y.-F. Zhu, F. Zhao, K. Jiao, H. Ehrlich, F. R. Tay, L.-N. Niu, Acta Biomater. 2023, 162, 32.
- 139K. Patoine, K. Ta, A. Gilbert, M. Percuoco, A. E. Gerdon, Acta Biomater. 2024, 179, 234.
- 140D. Granchi, N. Baldini, F. M. Ulivieri, R. Caudarella, Nutrients 2019, 11, 2576.
- 141X. Tan, E. Gerhard, Y. Wang, R. T. Tran, H. Xu, S. Yan, E. B. Rizk, A. D. Armstrong, Y. Zhou, J. Du, X. Bai, J. Yang, Small 2022, 18, 2203003.
- 142W. Chen, J. Xiao, Y. Zhou, W. Liu, J. Jian, J. Yang, B. Chen, Z. Ye, J. Liu, X. Xu, T. Jiang, H. Wang, W. Liu, Phytomedicine 2024, 133, 155922.
- 143W. Jin, Y. Jin, P. Duan, H. Wu, L. Zhang, Q. Du, H. Pan, R. Tang, C. Shao, J. Mater. Chem. B 2022, 10, 5826.
- 144S. Liu, H. Zhou, H. Liu, H. Ji, W. Fei, E. Luo, Cell Prolif 2019, 52, e12613.
- 145W. Fang, H. Ping, Y. Huang, H. Xie, H. Wang, W. Wang, Z. Fu, J. Mater. Chem. B 2021, 9, 6668.
- 146Z. Song, H. Yu, L. Hou, Y. Dong, M. Hu, P. Wei, W. Wang, D. Qian, S. Cao, Z. Zheng, Z. Xu, B. Zhao, Y. Huang, W. Jing, X. Zhang, Adv. Funct. Materials 2024, 34, 2315382.
- 147H. Cheng, W. Jiang, F. M. Phillips, R. C. Haydon, Y. Peng, L. Zhou, H. H. Luu, N. An, B. Breyer, P. Vanichakarn, J. P. Szatkowski, J. Y. Park, T.-C. He, J. Bone Joint Surg. Am. 2003, 85, 1544.
- 148B. Khorsand, N. Nicholson, A.-V. Do, J. E. Femino, J. A. Martin, E. Petersen, B. Guetschow, D. C. Fredericks, A. K. Salem, J. Controlled Release 2017, 248, 53.
- 149C. Siverino, S. Fahmy-Garcia, V. Niklaus, N. Kops, L. Dolcini, M. M. Misciagna, Y. Ridwan, E. Farrell, G. J. V. M. van Osch, J. Nickel, Bioact. Mater. 2023, 29, 241.
- 150W. J. King, P. H. Krebsbach, Adv. Drug Delivery Rev. 2012, 64, 1239.
- 151A. L. Shimer, F. C. Öner, A. R. Vaccaro, Injury 2009, 40, S32.
- 152N. Shen, T. Wang, Q. Gan, S. Liu, L. Wang, B. Jin, Food Chem. 2022, 383, 132531.
- 153Y. Yu, P. Li, C. Zhu, N. Ning, S. Zhang, G. J. Vancso, Adv. Funct. Mater. 2019, 29, 1904402.
- 154X. Zeng, B. Chen, L. Wang, Y. Sun, Z. Jin, X. Liu, L. Ouyang, Y. Liao, Bioact. Mater. 2023, 19, 653.
- 155S. Jin, R. Yang, C. Hu, S. Xiao, Y. Zuo, Y. Man, Y. Li, J. Li, ACS Appl. Mater. Interfaces 2023, 15, 7804.
- 156Y. Zuo, Q. Li, Q. Xiong, J. Li, C. Tang, Y. Zhang, D. Wang, Polymers 2022, 14, 3260.
- 157L. Yu, Y. Shen, J. Yang, X. Feng, C. Zhou, J. Lin, J. Orthop. Surg. Res. 2023, 18, 903.
- 158J. Cui, X. Yu, B. Yu, X. Yang, Z. Fu, J. Wan, M. Zhu, X. Wang, K. Lin, Adv. Healthcare Mater. 2022, 11, 2200571.
- 159B. Wu, Y. Tang, K. Wang, X. Zhou, L. Xiang, Int. J. Nanomed. 2022, 17, 1865.
- 160H. Han, I. Jun, H. Seok, K. Lee, K. Lee, F. Witte, D. Mantovani, Y. Kim, S. Glyn-Jones, J. R. Edwards, Adv. Sci. 2020, 7, 2000800.
- 161Q. Qin, S. Lee, N. Patel, K. Walden, M. Gomez-Salazar, B. Levi, A. W. James, Exp. Mol. Med. 2022, 54, 1844.
- 162E. J. Ryan, A. J. Ryan, A. González-Vázquez, A. Philippart, F. E. Ciraldo, C. Hobbs, V. Nicolosi, A. R. Boccaccini, C. J. Kearney, F. J. O'Brien, Biomaterials 2019, 197, 405.
- 163Z. Chen, T. Klein, R. Z. Murray, R. Crawford, J. Chang, C. Wu, Y. Xiao, Mater. Today 2016, 19, 304.
- 164B. Wu, Y. Tang, K. Yao, X. Luo, S. Feng, K. Wang, X. Zhou, L. Xiang, Nanoscale 2024, 16, 7167.
- 165Y. Zhu, H. Liang, X. Liu, J. Wu, C. Yang, T. M. Wong, K. Y. H. Kwan, K. M. C. Cheung, S. Wu, K. W. K. Yeung, Sci. Adv. 2021, 7, eabf6654.
- 166J. Lee, H. Byun, S. K. Madhurakkat Perikamana, S. Lee, H. Shin, Adv. Healthc. Mater 2019, 8, 1801106.
- 167D. M. Mosser, J. P. Edwards, Nat. Rev. Immunol. 2008, 8, 958.
- 168C. Li, C. Li, Z. Ma, H. Chen, H. Ruan, L. Deng, J. Wang, W. Cui, Bioact. Mater. 2023, 19, 474.
- 169G. Xiang, K. Liu, T. Wang, X. Hu, J. Wang, Z. Gao, W. Lei, Y. Feng, T. H. Tao, Adv. Sci. 2021, 8, 2002328.
- 170P. Tian, L. Zhao, J. Kim, X. Li, C. Liu, X. Cui, T. Liang, Y. Du, X. Chen, H. Pan, Bioact. Mater. 2023, 26, 231.
- 171S.-S. Jin, D.-Q. He, D. Luo, Y. Wang, M. Yu, B. Guan, Y. Fu, Z.-X. Li, T. Zhang, Y.-H. Zhou, C.-Y. Wang, Y. Liu, ACS Nano 2019, 13, 6581.
- 172J. Pajarinen, T. Lin, E. Gibon, Y. Kohno, M. Maruyama, K. Nathan, L. Lu, Z. Yao, S. B. Goodman, Biomaterials 2019, 196, 80.
- 173Y. Zhang, Z. Li, B. Guo, Q. Wang, L. Chen, L. Zhu, T. Zhang, R. Wang, W. Li, D. Luo, Y. Liu, Small 2024, 20, 2309230.
- 174Y. Zhou, Z. Hu, W. Jin, H. Wu, M. Zuo, C. Shao, Y. Lan, Y. Shi, R. Tang, Z. Chen, Z. Xie, J. Shi, Adv. Healthcare Mater. 2023, 12, 2201548.
- 175B. Cai, D. Lin, Y. Li, L. Wang, J. Xie, T. Dai, F. Liu, M. Tang, L. Tian, Y. Yuan, L. Kong, S. G. F. Shen, Adv. Sci. 2021, 8, 2100584.
- 176F. Yu, R. Lian, L. Liu, T. Liu, C. Bi, K. Hong, S. Zhang, J. Ren, H. Wang, N. Ouyang, L.-J. Du, Y. Liu, L. Zhou, Y. Liu, B. Fang, Y. Li, S.-Z. Duan, L. Xia, ACS Nano 2022, 16, 755.
- 177S. E. Blair, N. N. Cokcetin, E. J. Harry, D. A. Carter, Eur J. Clin. Microbiol. Infect. Dis. 2009, 28, 1199.
- 178M. J. Dewey, A. J. Collins, A. Tiffany, V. R. Barnhouse, C. Lu, V. Kolliopoulos, I. Mutreja, N. J. Hickok, B. A. C. Harley, Biomaterials 2023, 294, 122015.
- 179Y. Tang, K. Wang, B. Wu, K. Yao, S. Feng, X. Zhou, L. Xiang, Adv. Mater. 2024, 36, 2307756.
- 180X. Chen, Z. Sun, X. Peng, N. Meng, L. Ma, J. Fu, J. Chen, Y. Liu, Y. Yang, C. Zhou, ACS Appl. Mater. Interfaces 2024, 16, 50369.
- 181E. J. Sheehy, C. von Diemling, E. Ryan, A. Widaa, P. O’ Donnell, A. Ryan, G. Chen, R. T. Brady, A. López-Noriega, S. Zeiter, T. F. Moriarty, F. J. O’ Brien, Biomaterials 2025, 313, 122774.
- 182K. I. Ko, A. Sculean, D. T. Graves, Transl. Res. 2021, 236, 72.
- 183M. A. Terkawi, G. Matsumae, T. Shimizu, D. Takahashi, K. Kadoya, N. Iwasaki, Int. J. Mol. Sci. 2022, 23, 1786.
- 184Y. Wei, M. Shi, J. Zhang, X. Zhang, K. Shen, R. Wang, R. J. Miron, Y. Xiao, Y. Zhang, Adv. Funct. Mater. 2020, 30, 2000015.
