Review
Advancement of Engineered Bacteria for Orally Delivered Therapeutics
Peilin Guo,
Shuang Wang,
Hua Yue,
Xiao Zhang,
Guanghui Ma,
Xin Li,
Wei Wei,
Peilin Guo
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
Search for more papers by this authorShuang Wang
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
Search for more papers by this authorHua Yue
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
Search for more papers by this authorXiao Zhang
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
Search for more papers by this authorGuanghui Ma
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
Search for more papers by this authorCorresponding Author
Xin Li
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
E-mail: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Wei Wei
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
E-mail: [email protected]; [email protected]
Search for more papers by this authorPeilin Guo,
Shuang Wang,
Hua Yue,
Xiao Zhang,
Guanghui Ma,
Xin Li,
Wei Wei,
Peilin Guo
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
Search for more papers by this authorShuang Wang
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
Search for more papers by this authorHua Yue
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
Search for more papers by this authorXiao Zhang
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
Search for more papers by this authorGuanghui Ma
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
Search for more papers by this authorCorresponding Author
Xin Li
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
E-mail: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Wei Wei
State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190 P. R. China
School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049 P. R. China
E-mail: [email protected]; [email protected]
Search for more papers by this authorAbstract
The use of bacteria and their biotic components as therapeutics has shown great potential in the treatment of diseases. Orally delivered bacteria improve patient compliance compared with injection-administered bacteria and are considered the preferred mode. However, due to the harsh gastrointestinal environment, the viability and therapeutic efficacy of orally delivered bacteria are significantly reduced in vivo. In recent years, with the rapid development of synthetic biology and nanotechnology, bacteria and biotic components have been engineered to achieve directed genetic reprogramming for construction and precise spatiotemporal control in the gastrointestinal tract, which can improve viability and therapeutic efficiency. Herein, a state-of-the-art review on the current progress of engineered bacterial systems for oral delivery is provided. The different types of bacterial and biotic components for oral administration are first summarized. The engineering strategies of these bacteria and biotic components and their treatment of diseases are next systematically summarized. Finally, the current challenges and prospects of these bacterial therapeutics are highlighted that will contribute to the development of next-generation orally delivered bacteriotherapy.
Conflict of Interest
The authors declare no conflict of interest.
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