Somatostatin Receptor-Mediated Tumor-Targeting Nanocarriers Based on Octreotide-PEG Conjugated Nanographene Oxide for Combined Chemo and Photothermal Therapy
Xuyuan Zhang
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, No. 24 Tong Jia Xiang, Nanjing, 210009 China
Search for more papers by this authorChongyin Yang
Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD, 20742 USA
Search for more papers by this authorCorresponding Author
Jianping Zhou
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, No. 24 Tong Jia Xiang, Nanjing, 210009 China
E-mail: [email protected], [email protected]Search for more papers by this authorCorresponding Author
Meirong Huo
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, No. 24 Tong Jia Xiang, Nanjing, 210009 China
E-mail: [email protected], [email protected]Search for more papers by this authorXuyuan Zhang
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, No. 24 Tong Jia Xiang, Nanjing, 210009 China
Search for more papers by this authorChongyin Yang
Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, MD, 20742 USA
Search for more papers by this authorCorresponding Author
Jianping Zhou
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, No. 24 Tong Jia Xiang, Nanjing, 210009 China
E-mail: [email protected], [email protected]Search for more papers by this authorCorresponding Author
Meirong Huo
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, No. 24 Tong Jia Xiang, Nanjing, 210009 China
E-mail: [email protected], [email protected]Search for more papers by this authorAbstract
Nano-sized in vivo active targeting drug delivery systems have been developed to a high anti-tumor efficacy strategy against certain cancer-cells-specific. Graphene based nanocarriers with unique physical and chemical properties have shown significant potentials in this aspect. Here, octreotide (OCT), an efficient biotarget molecule, is conjugated to PEGylated nanographene oxide (NGO) drug carriers for the first time. The obtained NGO-PEG-OCT complex shows low toxicity and excellent stability in vivo and is able to achieve somatostatin receptor-mediated tumor-specific targeting delivery. Owing to the high loading efficiency and accurate targeting delivery of anti-cancer drug doxorubicin (DOX), our DOX loaded NGO-PEG-OCT complex offers a remarkably improved cancer-cell-specific cellular uptake, chemo-cytotoxicity, and decreased systemic toxicity compared to free DOX or NGO-PEG. More importantly, due to its strong near-infrared absorption, the NGO-PEG-OCT complex further enhances efficient photothermal ablation of tumors, delivering combined chemo and photothermal therapeutic effect against cancer cells.
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