The Effects of Curcumin and Curcumin–Phospholipid Complex on the Serum Pro-oxidant–Antioxidant Balance in Subjects with Metabolic Syndrome
Maryam Ghazimoradi
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
These authors share equal first authorship.Search for more papers by this authorMaryam Saberi-Karimian
Student Research Committee, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
These authors share equal first authorship.Search for more papers by this authorFarzane Mohammadi
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Search for more papers by this authorCorresponding Author
Amirhossein Sahebkar
Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Correspondence to: Dr. Amirhosein Sahebkar, Department of Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Dr. Majid Ghayour-Mobarhan, Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
E-mail: [email protected] (Dr. Amirhosein Sahebkar); [email protected] (Dr. Majid Ghayour-Mobarhan)
Search for more papers by this authorShima Tavallaie
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Search for more papers by this authorHamideh Safarian
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Search for more papers by this authorGordon A. Ferns
Brighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, BN1 9PH UK
Search for more papers by this authorCorresponding Author
Majid Ghayour-Mobarhan
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Correspondence to: Dr. Amirhosein Sahebkar, Department of Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Dr. Majid Ghayour-Mobarhan, Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
E-mail: [email protected] (Dr. Amirhosein Sahebkar); [email protected] (Dr. Majid Ghayour-Mobarhan)
Search for more papers by this authorMohsen Moohebati
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Search for more papers by this authorHabibollah Esmaeili
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
Search for more papers by this authorMalihe Ahmadinejad
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Search for more papers by this authorMaryam Ghazimoradi
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
These authors share equal first authorship.Search for more papers by this authorMaryam Saberi-Karimian
Student Research Committee, Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
These authors share equal first authorship.Search for more papers by this authorFarzane Mohammadi
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Search for more papers by this authorCorresponding Author
Amirhossein Sahebkar
Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Correspondence to: Dr. Amirhosein Sahebkar, Department of Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Dr. Majid Ghayour-Mobarhan, Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
E-mail: [email protected] (Dr. Amirhosein Sahebkar); [email protected] (Dr. Majid Ghayour-Mobarhan)
Search for more papers by this authorShima Tavallaie
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Search for more papers by this authorHamideh Safarian
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Search for more papers by this authorGordon A. Ferns
Brighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex, BN1 9PH UK
Search for more papers by this authorCorresponding Author
Majid Ghayour-Mobarhan
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Correspondence to: Dr. Amirhosein Sahebkar, Department of Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Dr. Majid Ghayour-Mobarhan, Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
E-mail: [email protected] (Dr. Amirhosein Sahebkar); [email protected] (Dr. Majid Ghayour-Mobarhan)
Search for more papers by this authorMohsen Moohebati
Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Search for more papers by this authorHabibollah Esmaeili
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran
Search for more papers by this authorMalihe Ahmadinejad
Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Search for more papers by this authorAbstract
Metabolic syndrome (MetS) is defined by a clustering of metabolic and anthropometric abnormalities and is associated by an increased risk of cardiovascular disease. We have investigated the effect of curcumin supplementation on the serum pro-oxidant–antioxidant balance (PAB) in patients with MetS. This double-blind, randomized, placebo-controlled trial was conducted over 6 weeks. Subjects (n = 120) were randomly allocated to one of three groups (curcumin, phospholipidated curcumin, and placebo). The curcumin group received 1 g/day of simple curcumin, the phospholipidated curcumin group received 1 g/day of phospholipidated curcumin (containing 200 mg of pure curcumin), and the control group received 1 g/day of placebo. Serum PAB was measured before and after the intervention (at baseline and at 6 weeks). Data analyses were performed using spss software (version 16.0). Serum PAB increased significantly in the curcumin group (p < 0.001), but in the phospholipidated curcumin group, elevation of PAB level was not significant (p = 0.053). The results of our study did not suggest any improvement of PAB following supplementation with curcumin in MetS subjects. Copyright © 2017 John Wiley & Sons, Ltd.
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