Characterization and correction of the effects of hepatic iron on T1ρ relaxation in the liver at 3.0T
Yurui Qian
Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorJian Hou
Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorBaiyan Jiang
Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Hong Kong, China
Illuminatio Medical Technology Limited, Hong Kong, China
Search for more papers by this authorVincent Wai-Sun Wong
Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorJack Lee
Clinical Trials and Biostatistics Lab, CUHK Shenzhen Research Institute, Shenzhen, China
Division of Biostatistics, Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorYixiang Wang
Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorWinnie Chiu-Wing Chu
Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorCorresponding Author
Weitian Chen
Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Hong Kong, China
Correspondence
Weitian Chen, Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
Email: [email protected]
Search for more papers by this authorYurui Qian
Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorJian Hou
Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorBaiyan Jiang
Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Hong Kong, China
Illuminatio Medical Technology Limited, Hong Kong, China
Search for more papers by this authorVincent Wai-Sun Wong
Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorJack Lee
Clinical Trials and Biostatistics Lab, CUHK Shenzhen Research Institute, Shenzhen, China
Division of Biostatistics, Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorYixiang Wang
Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorWinnie Chiu-Wing Chu
Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Hong Kong, China
Search for more papers by this authorCorresponding Author
Weitian Chen
Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Hong Kong, China
Correspondence
Weitian Chen, Department of Imaging and Interventional Radiology, the Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
Email: [email protected]
Search for more papers by this authorFunding information:
Hong Kong Health and Medical Research Fund (HMRF), Grant/Award Number: 06170166; Innovation and Technology Commission of the Hong Kong SAR, Grant/Award Number: Project MRP/046/20X; Research Grants Council of the Hong Kong SAR, Grant/Award Number: Project SEG CUHK02
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Abstract
Purpose
Quantitative T1ρ imaging is an emerging technique to assess the biochemical properties of tissues. In this paper, we report our observation that liver iron content (LIC) affects T1ρ quantification of the liver at 3.0T field strength and develop a method to correct the effect of LIC.
Theory and Methods
On-resonance R1ρ (1/T1ρ) is mainly affected by the intrinsic R2 (1/T2), which is influenced by LIC. As on-resonance R1ρ is closely related to the Carr–Purcell–Meiboom–Gill (CPMG) R2, and because the calibration between CPMG R2 and LIC has been reported at 1.5T, a correction method was proposed to correct the R2 contribution to the R1ρ. The correction coefficient was obtained from the calibration results and related transformed factors. To compensate for the difference between CPMG R2 and R1ρ, a scaling factor was determined using the values of CPMG R2 and R1ρ, obtained simultaneously from a single breath-hold from volunteers. The livers of 110 subjects were scanned to validate the correction method.
Results
LIC was significantly correlated with R1ρ in the liver. However, when the proposed correction method was applied to R1ρ, LIC and the iron-corrected R1ρ were not significantly correlated.
Conclusion
LIC can affect T1ρ in the liver. We developed an iron-correction method for the quantification of T1ρ in the liver at 3.0T.
CONFLICT OF INTEREST
Queenie Chan is an employee of Philips Healthcare
Supporting Information
| Filename | Description |
|---|---|
| mrm29310-sup-0001-supinfo.docxWord 2007 document , 372.4 KB | Figure S1 Liver relaxation rate R1ρ and R2 maps from 1 subject with 3 different slices. Figure S2 Typical B1 maps from the same subject with 3 different slices. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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