A probabilistic Bayesian approach to recover map and phase images for quantitative susceptibility mapping
Shuai Huang
Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia, USA
Search for more papers by this authorJames J. Lah
Department of Neurology, Emory University, Atlanta, Georgia, USA
Search for more papers by this authorJason W. Allen
Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia, USA
Search for more papers by this authorCorresponding Author
Deqiang Qiu
Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia, USA
Correspondence
Deqiang Qiu, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Email: [email protected]
Search for more papers by this authorShuai Huang
Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia, USA
Search for more papers by this authorJames J. Lah
Department of Neurology, Emory University, Atlanta, Georgia, USA
Search for more papers by this authorJason W. Allen
Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia, USA
Search for more papers by this authorCorresponding Author
Deqiang Qiu
Department of Radiology and Imaging Sciences, Emory University, Atlanta, Georgia, USA
Correspondence
Deqiang Qiu, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30322, USA.
Email: [email protected]
Search for more papers by this authorFunding information: National Institutes of Health, Grant/Award Numbers: P30AG066511; R01AG072603; R21AG064405
Click here for author-reader discussions
Abstract
Purpose
Undersampling is used to reduce the scan time for high-resolution three-dimensional magnetic resonance imaging. In order to achieve better image quality and avoid manual parameter tuning, we propose a probabilistic Bayesian approach to recover map and phase images for quantitative susceptibility mapping (QSM), while allowing automatic parameter estimation from undersampled data.
Theory
Sparse prior on the wavelet coefficients of images is interpreted from a Bayesian perspective as sparsity-promoting distribution. A novel nonlinear approximate message passing (AMP) framework that incorporates a mono-exponential decay model is proposed. The parameters are treated as unknown variables and jointly estimated with image wavelet coefficients.
Methods
Undersampling takes place in the y-z plane of k-space according to the Poisson-disk pattern. Retrospective undersampling is performed to evaluate the performances of different reconstruction approaches, prospective undersampling is performed to demonstrate the feasibility of undersampling in practice.
Results
The proposed AMP with parameter estimation (AMP-PE) approach successfully recovers maps and phase images for QSM across various undersampling rates. It is more computationally efficient, and performs better than the state-of-the-art -norm regularization (L1) approach in general, except a few cases where the L1 approach performs as well as AMP-PE.
Conclusion
AMP-PE achieves better performance by drawing information from both the sparse prior and the mono-exponential decay model. It does not require parameter tuning, and works with a clinical, prospective undersampling scheme where parameter tuning is often impossible or difficult due to the lack of ground-truth image.
Supporting Information
Filename | Description |
---|---|
mrm29303-sup-0001-Supinfo.pdfPDF document, 19.6 MB | Figure S1. Retrospective undersampling: sagittal views of recovered QSM using the least squares approach (LSQ), the l1-norm regularization approach with parameter tuning (L1-T) and L-curve method (L1-L), the proposed AMP-PE approach. Figure S2. Retrospective undersampling: coronal views of recovered QSM using the least squares approach (LSQ), the l1-norm regularization approach with parameter tuning (L1-T) and L-curve method (L1-L), the proposed AMP-PE approach. Figure S3. Retrospective undersampling: axial views of recovered local field maps using the least squares approach (LSQ), the l1-norm regularization approach with parameter tuning (L1-T) and L-curve method (L1-L), the proposed AMP-PE approach. Figure S4. Retrospective undersampling: sagittal views of recovered local field maps using the least squares approach (LSQ), the l1-norm regularization approach with parameter tuning (L1-T) and L-curve method (L1-L), the proposed AMP-PE approach. Figure S5. Retrospective undersampling: coronal views of recovered local field maps using the least squares approach (LSQ), the l1-norm regularization approach with parameter tuning (L1-T) and L-curve method (L1-L), the proposed AMP-PE approach. Figure S6. Prospective undersampling: recovered initial magnetization using the least squares approach (LSQ), the l1-norm regularization approach with the L-curve method (L1-L), the proposed AMP-PE approach. Figure S7. Prospective undersampling: recovered map using the least squares approach (LSQ), the l1-norm regularization approach with the L-curve method (L1-L), the proposed AMP-PE approach. Figure S8. Prospective undersampling: axial view of recovered QSM using the least squares approach (LSQ), the l1-norm regularization approach with the L-curve method (L1-L), the proposed AMP-PE approach. Figure S9. Prospective undersampling: sagittal view of recovered QSM using the least squares approach (LSQ), the l1-norm regularization approach with the L-curve method (L1-L), the proposed AMP-PE approach. Figure S10. Prospective undersampling: coronal view of recovered QSM using the least squares approach (LSQ), the l1-norm regularization approach with the L-curve method (L1-L), the proposed AMP-PE approach. Figure S11. The Poisson-disk sampling pattern produces a more uniform sampling across k-space than the random sampling pattern. Figure S12. Comparison of the recovered initial magnetizations using random sampling and Poisson-disk sampling with the proposed AMP-PE approach. The Poisson-disk sampling pattern leads to lower errors. Figure S13. Comparison of the recovered map using random sampling and Poisson-disk sampling with the proposed AMP-PE approach. The Poisson-disk sampling pattern leads to lower errors. Figure S14. Comparison of the recovered QSM using random sampling and Poisson-disk sampling with the proposed AMP-PE approach. The Poisson-disk sampling pattern leads to lower errors. Figure S15. Comparison of the recovered using Bernoulli–Gaussian-mixture prior and the Laplace prior with the proposed AMP-PE approach. The Laplace prior leads to lower errors. Table S1. Retrospective undersampling (P1-R): pixel-wise absolute errors of recovered images across different subjects. Table S2. Retrospective undersampling (P2-R): pixel-wise absolute errors of recovered images across different subjects. Table S3. Retrospective undersampling: HFEN values of recovered QSM . Table S4. Retrospective undersampling: normalized absolute errors of recovered local fields. Table S5. Retrospective undersampling: pixel-wise absolute errors of recovered local fields across different subjects. Table S6. Prospective undersampling (P1-P): normalized absolute errors of recovered images. Table S7. Prospective undersampling (P2-P): normalized absolute errors of recovered images. Table S8. Prospective undersampling (P1-P): pixel-wise absolute errors of recovered images across different subjects. Table S9. Prospective undersampling (P2-P): pixel-wise absolute errors of recovered images across different subjects. Table S10. Parameters in the l1-norm regularization approach. For retrospective undersampling, the 1st (S1) and 8th (S8) subjects are used as training data, the rest are used as test data. Table S11. Retrospective undersampling (P1-R): normalized absolute errors of recovered images from L1 with Exhaustive search (L1-E) and AMP. Table S12. Retrospective undersampling (P2-R): normalized absolute errors of recovered images from L1 with Exhaustive search (L1-E) and AMP. Algorithm S1. Recovery of the multi-echo image distribution (zin | y). Algorithm S2. Recovery of map , initial magnetization z0 and multi-echo image zi. |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
REFERENCES
- 1Bernstein MA, King KF, Zhou XJ. Handbook of MRI Pulse Sequences. Elsevier Academic Press; 2004.
- 2Mamisch TC, Hughes T, Mosher TJ, et al. T2 star relaxation times for assessment of articular cartilage at 3 t: a feasibility study. Skelet Radiol. 2012; 41: 287-292.
- 3Wang Y, Liu T. Quantitative susceptibility mapping (QSM): decoding MRI data for a tissue magnetic biomarker. Magn Reson Med. 2015; 73: 82-101.
- 4Langkammer C, Liu T, Khalil M, et al. Quantitative susceptibility mapping in multiple sclerosis. Radiology. 2013; 267: 551-559.
- 5Deistung A, Schäfer A, Schweser F, Biedermann U, Turner R, Reichenbach JR. Toward in vivo histology: a comparison of quantitative susceptibility mapping (QSM) with magnitude-, phase-, and r2*-imaging at ultra-high magnetic field strength. NeuroImage. 2013; 65: 299-314.
- 6Barbosa JHO, Santos AC, Tumas V, et al. Quantifying brain iron deposition in patients with Parkinson's disease using quantitative susceptibility mapping, r2 and r2*. Magn Reson Imaging. 2015; 33: 559-565.
- 7Betts MJ, Acosta-Cabronero J, Cardenas-Blanco A, Nestor PJ, Düzel E. High-resolution characterisation of the aging brain using simultaneous quantitative susceptibility mapping (QSM) and r2* measurements at 7t. NeuroImage. 2016; 138: 43-63.
- 8Qiu D, Chan G-F, Chu J, et al. MR quantitative susceptibility imaging for the evaluation of iron loading in the brains of patients with -thalassemia major. Am J Neuroradiol. 2014; 35: 1085-1090.
- 9Ordidge RJ, Gorell JM, Deniau JC, Knight RA, Helpern JA. Assessment of relative brain iron concentrations using t2-weighted and t2*-weighted MRI at 3 tesla. Magn Reson Med. 1994; 32: 335-341.
- 10McNeill A, Birchall D, Hayflick SJ, et al. T2* and FSE MRI distinguishes four subtypes of neurodegeneration with brain iron accumulation. Neurology. 2008; 70: 1614-1619.
- 11Langkammer C, Schweser F, Krebs N, et al. Quantitative susceptibility mapping (QSM) as a means to measure brain iron? A post mortem validation study. NeuroImage. 2012; 62: 1593-1599.
- 12Schweser F, Sommer K, Deistung A, Reichenbach JR. Quantitative susceptibility mapping for investigating subtle susceptibility variations in the human brain. NeuroImage. 2012; 62: 2083-2100.
- 13Li W, Wu B, Liu C. Quantitative susceptibility mapping of human brain reflects spatial variation in tissue composition. NeuroImage. 2011; 55: 1645-1656.
- 14Fazekas F, Kleinert R, Roob G, et al. Histopathologic analysis of foci of signal loss on gradient-echo t2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds. Am J Neuroradiol. 1999; 20: 637-642.
- 15Kinoshita T, Okudera T, Tamura H, Ogawa T, Hatazawa J. Assessment of lacunar hemorrhage associated with hypertensive stroke by echo-planar gradient-echo t2*-weighted MRI. Stroke. 2000; 31: 1646-1650.
- 16O'Regan DP, Ahmed R, Karunanithy N, et al. Reperfusion hemorrhage following acute myocardial infarction: assessment with t2* mapping and effect on measuring the area at risk. Radiology. 2009; 250: 916-922.
- 17Zhang Y, Wei H, Sun Y, et al. Quantitative susceptibility mapping (QSM) as a means to monitor cerebral hematoma treatment. J Magn Reson Imaging. 2018; 48: 907-915.
- 18Sun H, Klahr AC, Kate M, et al. Quantitative susceptibility mapping for following intracranial hemorrhage. Radiology. 2018; 288: 830-839.
- 19Yamada N, Imakita S, Sakuma T, Takamiya M. Intracranial calcification on gradient-echo phase image: depiction of diamagnetic susceptibility. Radiology. 1996; 198: 171-178.
- 20Gupta R, Rao S, Jain R, et al. Differentiation of calcification from chronic hemorrhage with corrected gradient echo phase imaging. J Comput Assist Tomogr. 2001; 25: 698-704.
- 21Deistung A, Schweser F, Wiestler B, et al. Quantitative susceptibility mapping differentiates between blood depositions and calcifications in patients with glioblastoma. PLoS One. 2013; 8: 1-8.
- 22Chen W, Zhu W, Kovanlikaya I, et al. Intracranial calcifications and hemorrhages: characterization with quantitative susceptibility mapping. Radiology. 2014; 270: 496-505.
- 23Pruessmann KP, Weiger M, Scheidegger MB, Boesiger P. Sense: sensitivity encoding for fast MRI. Magn Reson Med. 1999; 42: 952-962.
10.1002/(SICI)1522-2594(199911)42:5<952::AID-MRM16>3.0.CO;2-S CAS PubMed Web of Science® Google Scholar
- 24Griswold MA, Jakob PM, Heidemann RM, et al. Generalized autocalibrating partially parallel acquisitions (grappa). Magn Reson Med. 2002; 47: 1202-1210.
- 25Uecker M, Lai P, Murphy MJ, et al. Espirit–An eigenvalue approach to autocalibrating parallel MRI: where sense meets grappa. Magn Reson Med. 2014; 71: 990-1001.
- 26Candès EJ, Romberg J, Tao T. Robust uncertainty principles: exact signal reconstruction from highly incomplete frequency information. IEEE Trans Inf Theory. 2006; 52: 489-509.
- 27Donoho DL. Compressed sensing. IEEE Trans Inf Theory. 2006; 52: 1289-1306.
- 28Block KT, Uecker M, Frahm J. Model-based iterative reconstruction for radial fast spin-echo MRI. IEEE Trans Med Imaging. 2009; 28: 1759-1769.
- 29Zhao B, Lam F, Liang Z. Model-based MR parameter mapping with sparsity constraints: parameter estimation and performance bounds. IEEE Trans Med Imaging. 2014; 33: 1832-1844.
- 30Tamir JI, Uecker M, Chen W, et al. T2 shuffling: sharp, multicontrast, volumetric fast spin-echo imaging. Magn Reson Med. 2017; 77: 180-195.
- 31Candès EJ, Romberg JK, Tao T. Stable signal recovery from incomplete and inaccurate measurements. Commun Pure Appl Math. 2006; 59: 1207-1223.
- 32 Yang AY, Ganesh A, Zhou Z, Sastry SS, Ma Y. A review of fast l1-minimization algorithms for robust face recognition. CoRR. 2010; 1-13. abs/1007.3753.
- 33Tetko IV, Livingstone DJ, Luik AI. Neural network studies. 1. Comparison of overfitting and overtraining. J Chem Inf Comput Sci. 1995; 35: 826-833.
- 34Hawkins DM. The problem of overfitting. J Chem Inf Comput Sci. 2004; 44: 1-12.
- 35Hansen PC. The l-curve and its use in the numerical treatment of inverse problems. In: P Johnston, ed. Computational Inverse Problems in Electrocardiology. Advances in Computational Bioengineering. WIT Press; 2000: 119-142.
- 36Srivastava M, Anderson CL, Freed JH. A new wavelet denoising method for selecting decomposition levels and noise thresholds. IEEE Access. 2016; 4: 3862-3877.
- 37Khare K, Hardy CJ, King KF, Turski PA, Marinelli L. Accelerated MR imaging using compressive sensing with no free parameters. Magn Reson Med. 2012; 68: 1450-1457.
- 38Ahmad R, Schniter P. Iteratively reweighted approaches to sparse composite regularization. IEEE Trans Comput Imaging. 2015; 1: 220-235.
- 39Rangan S. Generalized approximate message passing for estimation with random linear mixing. Proceedings of IEEE ISIT; July 2011:2168-2172.
- 40Huang S, Tran TD. Sparse signal recovery using generalized approximate message passing with built-in parameter estimation. Proceedings of the IEEE ICASSP; March 2017:4321-4325.
- 41Donoho DL, Maleki A, Montanari A. Message-passing algorithms for compressed sensing. Proc Natl Acad Sci. 2009; 106: 18914-18919.
- 42Baron D, Sarvotham S, Baraniuk RG. Bayesian compressive sensing via belief propagation. IEEE Trans Signal Process. 2010; 58: 269-280.
- 43Guo C, Davies ME. Near optimal compressed sensing without priors: parametric sure approximate message passing. IEEE Trans Signal Process. 2015; 63: 2130-2141.
- 44Metzler CA, Maleki A, Baraniuk RG. From denoising to compressed sensing. IEEE Trans Inf Theory. 2016; 62: 5117-5144.
- 45Ma Y, Zhu J, Baron D. Approximate message passing algorithm with universal denoising and Gaussian mixture learning. IEEE Trans on Signal Process. 2016; 64: 5611-5622.
- 46Krzakala F, Mézard M, Sausset F, Sun YF, Zdeborová L. Statistical-physics-based reconstruction in compressed sensing. Phys Rev X. 2012; 2:021005.
- 47Vila JP, Schniter P. Expectation-maximization Gaussian-mixture approximate message passing. IEEE Trans Signal Process. 2013; 61: 4658-4672.
- 48Kamilov US, Rangan S, Fletcher AK, Unser M. Approximate message passing with consistent parameter estimation and applications to sparse learning. IEEE Trans Inf Theory. 2014; 60: 2969-2985.
- 49Krzakala F, Mézard M, Sausset F, Sun Y, Zdeborová L. Probabilistic reconstruction in compressed sensing: algorithms, phase diagrams, and threshold achieving matrices. J Stat Mech Theory Exp. 2012; 2012:P08009.
- 50Ziniel J, Schniter P. Dynamic compressive sensing of time-varying signals via approximate message passing. IEEE Trans Signal Process. 2013; 61: 5270-5284.
- 51Millard C, Hess AT, Mailhe B, Tanner J. An approximate message passing algorithm for rapid parameter-free compressed sensing MRI. Proceedings of the 2020 IEEE International Conference on Image Processing (ICIP); 2020:91-95.
- 52Qiao X, Du J, Wang L, He Z, Jia Y. A model-based deep network for MRI reconstruction using approximate message passing algorithm. Proceedings of the 2020 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP); 2020:1105-1109.
- 53Rich A, Potter LC, Jin N, Ash J, Simonetti OP, Ahmad R. A Bayesian model for highly accelerated phase-contrast MRI. Magn Reson Med. 2016; 76: 689-701.
- 54Rich A, Potter LC, Jin N, Liu Y, Simonetti OP, Ahmad R. A Bayesian approach for 4d flow imaging of aortic valve in a single breath-hold. Magn Reson Med. 2019; 81: 811-824.
- 55 Pruitt A, Rich A, Liu Y, et al. Fully self-gated whole-heart 4d flow imaging from a 5-minute scan. Magn Reson Med. 2021; 85: 1222-1236.
- 56Liu T, Wisnieff C, Lou M, Chen W, Spincemaille P, Wang Y. Nonlinear formulation of the magnetic field to source relationship for robust quantitative susceptibility mapping. Magn Reson Med. 2013; 69: 467-476.
- 57Liu J, Liu T, de Rochefort L, et al. Morphology enabled dipole inversion for quantitative susceptibility mapping using structural consistency between the magnitude image and the susceptibility map. NeuroImage. 2012; 59: 2560-2568.
- 58Nishimura DG. Principles of Magnetic Resonance Imaging. Stanford University; 2010.
- 59Daubechies I. Ten lectures on wavelets. Society for Industrial and Applied Mathematics; 1992.
10.1137/1.9781611970104 Google Scholar
- 60Bayati M, Montanari A. The dynamics of message passing on dense graphs, with applications to compressed sensing. IEEE Trans Inf Theory. 2011; 57: 764-785.
- 61Rangan S, Schniter P, Fletcher A. On the convergence of approximate message passing with arbitrary matrices. Proceedings of IEEE ISIT; 2014:236-240.
- 62Vila J, Schniter P, Rangan S, Krzakala F, Zdeborová L. Adaptive damping and mean removal for the generalized approximate message passing algorithm. Proceedings of the IEEE ICASSP; 2015:2021-2025.
- 63Kschischang FR, Frey BJ, Loeliger HA. Factor graphs and the sum-product algorithm. IEEE Trans Inf Theory. 2001; 47: 498-519.
- 64Koller D, Friedman N. Probabilistic Graphical Models: Principles and Techniques - Adaptive Computation and Machine Learning. The MIT Press; 2009.
- 65Minka TP. A Family of Algorithms for Approximate Bayesian Inference. PhD thesis. Massachusetts Institute of Technology; 2001.
- 66Minka T. Divergence measures and message passing. Technical report MSR-TR-2005-173, Microsoft Research Ltd., January 2005.
- 67Witten IH, Frank E, Hall MA. Ch. 5. Credibility: evaluating what's been learned. Data Mining: Practical Machine Learning Tools and Techniques. 3rd ed. Morgan Kaufmann; 2011: 147-187.
10.1016/B978-0-12-374856-0.00005-5 Google Scholar
- 68Beck A, Teboulle M. A fast iterative shrinkage-thresholding algorithm for linear inverse problems. SIAM J Imaging Sci. 2009; 2: 183-202.
- 69Li W, Avram AV, Wu B, Xiao X, Liu C. Integrated Laplacian-based phase unwrapping and background phase removal for quantitative susceptibility mapping. NMR Biomed. 2014; 27: 219-227.
- 70Liu T, Khalidov I, de Rochefort L, et al. A novel background field removal method for MRI using projection onto dipole fields (pdf). NMR Biomed. 2011; 24: 1129-1136.