Review
Elastin-Like Polypeptide Based Nanoparticles: Design Rationale Toward Nanomedicine
Ferdinanda C. M. Smits,
Bastiaan C. Buddingh,
Mark B. van Eldijk,
Jan C. M. van Hest,
Ferdinanda C. M. Smits
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands
These Authors contributed equally to this work.Search for more papers by this authorBastiaan C. Buddingh
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands
These Authors contributed equally to this work.Search for more papers by this authorMark B. van Eldijk
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands
Search for more papers by this authorCorresponding Author
Jan C. M. van Hest
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands
Search for more papers by this authorFerdinanda C. M. Smits,
Bastiaan C. Buddingh,
Mark B. van Eldijk,
Jan C. M. van Hest,
Ferdinanda C. M. Smits
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands
These Authors contributed equally to this work.Search for more papers by this authorBastiaan C. Buddingh
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands
These Authors contributed equally to this work.Search for more papers by this authorMark B. van Eldijk
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands
Search for more papers by this authorCorresponding Author
Jan C. M. van Hest
Radboud University Nijmegen, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands
Search for more papers by this authorAbstract
Elastin-like polypeptides (ELPs) are characterized by a high sequence control, temperature responsiveness and biocompatibility, which make them highly interesting as smart materials for application in nanomedicine. In particular the construction of ELP-based nanoparticles has recently become a focal point of attention in materials research. This review will give an overview of the ELP-based nanoparticles that have been developed until now and their underlying design principles. First a short introduction on ELPs and their stimulus-responsive behavior will be given. This characteristic has been applied for the development of ELP-based block copolymers that can self-assemble into nanoparticles. Both the fully ELP-based as well as several ELP hybrid materials that have been reported to form nanoparticles will be discussed, which is followed by a concise description of the promising biomedical applications reported for this class of materials.
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