Comparative study of the binding of 3 flavonoids to the fat mass and obesity-associated protein by spectroscopy and molecular modeling
Lijiao Zhang
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorTing Ren
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorZechun Wang
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorCorresponding Author
Ruiyong Wang
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China
Correspondence
Ruiyong Wang and Junbiao Chang, College of Chemistry and Molecular Engineering, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, China.
Email: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Junbiao Chang
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China
Correspondence
Ruiyong Wang and Junbiao Chang, College of Chemistry and Molecular Engineering, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, China.
Email: [email protected]; [email protected]
Search for more papers by this authorLijiao Zhang
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorTing Ren
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorZechun Wang
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China
Search for more papers by this authorCorresponding Author
Ruiyong Wang
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China
Correspondence
Ruiyong Wang and Junbiao Chang, College of Chemistry and Molecular Engineering, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, China.
Email: [email protected]; [email protected]
Search for more papers by this authorCorresponding Author
Junbiao Chang
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, China
Correspondence
Ruiyong Wang and Junbiao Chang, College of Chemistry and Molecular Engineering, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, China.
Email: [email protected]; [email protected]
Search for more papers by this authorAbstract
This study aims to investigate the interaction between 3 flavonoids (quercetin, apigenin, and naringenin) and fat mass and obesity-associated protein by fluorescence, ultraviolet-visible absorption spectroscopy, and molecular modeling. Results indicate that the intrinsic fluorescence of fat mass and obesity-associated protein can be quenched by the 3 flavonoids through a static quenching procedure. Thermodynamic analysis and molecular modeling results suggest that hydrophobic interaction and hydrogen bond forces play the major roles in the binding process. Moreover, results also show that the rank order of quenching constant and binding constant is quercetin > apigenin > naringenin.
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