Volume 55, Issue 10 pp. 2224-2250
Review

Recent Progress on Nicotinonitrile Scaffold-based Anticancer, Antitumor, and Antimicrobial Agents: A Literature Review

Moustafa A. Gouda

Corresponding Author

Moustafa A. Gouda

Department of Chemistry, Faculty of Science and Arts, Ulla, Taibah University, Medina, Saudi Arabia

Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura, 35516 Egypt

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Ehab Attia

Ehab Attia

Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura, 35516 Egypt

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Mohamed H. Helal

Mohamed H. Helal

Department of Chemistry, Faculty of Arts and Science, Northern Border University, Rafha, Saudi Arabia

Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, 11284 Cairo, Egypt

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Mohammed A. Salem

Mohammed A. Salem

Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, 11284 Cairo, Egypt

Department of Chemistry, Faculty of Arts and Science, King Khalid University, Abha, Muhayil Asir, Saudi Arabia

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First published: 31 August 2018
Citations: 17

Abstract

The considerable biological activities of nicotinonitriles and its analogues are attracting attention of chemist aimed at developing synthetic routes to these nuclei. This review focuses on the synthesis and anticancer, antitumor, and antimicrobial activities of nicotinonitriles and their analogues.

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