Article
Synthesis of Novel Bis(thiazolylchromen-2-one) Derivatives Linked to Alkyl Spacer via Phenoxy Group
Mohamed Hosny,
Mostafa E. Salem,
Ahmed F. Darweesh,
Ahmed H. M. Elwahy,
Mohamed Hosny
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
Search for more papers by this authorMostafa E. Salem
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
Search for more papers by this authorAhmed F. Darweesh
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
Search for more papers by this authorCorresponding Author
Ahmed H. M. Elwahy
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
E-mail: [email protected]Search for more papers by this authorMohamed Hosny,
Mostafa E. Salem,
Ahmed F. Darweesh,
Ahmed H. M. Elwahy,
Mohamed Hosny
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
Search for more papers by this authorMostafa E. Salem
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
Search for more papers by this authorAhmed F. Darweesh
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
Search for more papers by this authorCorresponding Author
Ahmed H. M. Elwahy
Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt
E-mail: [email protected]Search for more papers by this authorAbstract
A novel series of bis(thiazolylchromen-2-one) derivatives 8 were prepared in good yields by the reaction of the appropriate bis(α-bromoketones) 7 with 2-(1-(2-oxo-2H-chromen-3-yl)ethylidene) hydrazinecarbothioamide (6) in refluxing EtOH in the presence of few drops of TEA. Some other isomeric derivatives of bis(thiazolylchromen-2-one) 11 and 13 were also successfully obtained by the reaction of bromoacetylcoumarin 9 with the corresponding bis(ethan-1-yl-1-ylidene))bis(hydrazinecarbothioamides) 10 and 12. The structures of the new compounds were established based on elemental analyses as well as spectral data.
References and Notes
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